Plasma levels of soluble CD14 and tumor necrosis factor-α type II receptor correlate with cognitive dysfunction during human immunodeficiency virus type 1 infection

L. A. Ryan, Jialin C Zheng, M. Brester, D. Bohac, F. Hahn, J. Anderson, W. Ratanasuwan, Howard Eliot Gendelman, Susan Swindells

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

The relationship between monocyte immune responses and cognitive impairment during progressive human immunodeficiency virus type 1 (HIV-1) infection was investigated in 28 subjects receiving highly active antiretroviral therapy. The mean ± SEM CD4+ T lymphocyte count and virus load for all patients were 237 ± 41 cells/mm3 and 77,091 ± 195,372 HIV-1 RNA copies/mL, respectively. Levels of soluble tumor necrosis factor-α type II receptor (sTNF-RII) and soluble CD14 (sCD14) were measured in plasma by ELISA and were correlated with results from neuropsychological, magnetic resonance imaging, and magnetic resonance spectroscopy tests. Plasma sCD14 and sTNF-RII levels were elevated in subjects with cognitive impairment and in those with brain atrophy. Furthermore, both factors were correlated with spectroscopic choline:creatine ratios. These findings support the idea that peripheral immune responses are linked to cognitive dysfunction during advanced HIV-1 disease.

Original languageEnglish (US)
Pages (from-to)699-706
Number of pages8
JournalJournal of Infectious Diseases
Volume184
Issue number6
DOIs
StatePublished - Sep 15 2001

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Receptors, Tumor Necrosis Factor, Type II
Virus Diseases
HIV-1
Reticuloendotheliosis virus
Creatine
Highly Active Antiretroviral Therapy
CD4 Lymphocyte Count
Choline
Atrophy
Monocytes
Magnetic Resonance Spectroscopy
Enzyme-Linked Immunosorbent Assay
Magnetic Resonance Imaging
RNA
T-Lymphocytes
Brain
Cognitive Dysfunction

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Plasma levels of soluble CD14 and tumor necrosis factor-α type II receptor correlate with cognitive dysfunction during human immunodeficiency virus type 1 infection. / Ryan, L. A.; Zheng, Jialin C; Brester, M.; Bohac, D.; Hahn, F.; Anderson, J.; Ratanasuwan, W.; Gendelman, Howard Eliot; Swindells, Susan.

In: Journal of Infectious Diseases, Vol. 184, No. 6, 15.09.2001, p. 699-706.

Research output: Contribution to journalArticle

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abstract = "The relationship between monocyte immune responses and cognitive impairment during progressive human immunodeficiency virus type 1 (HIV-1) infection was investigated in 28 subjects receiving highly active antiretroviral therapy. The mean ± SEM CD4+ T lymphocyte count and virus load for all patients were 237 ± 41 cells/mm3 and 77,091 ± 195,372 HIV-1 RNA copies/mL, respectively. Levels of soluble tumor necrosis factor-α type II receptor (sTNF-RII) and soluble CD14 (sCD14) were measured in plasma by ELISA and were correlated with results from neuropsychological, magnetic resonance imaging, and magnetic resonance spectroscopy tests. Plasma sCD14 and sTNF-RII levels were elevated in subjects with cognitive impairment and in those with brain atrophy. Furthermore, both factors were correlated with spectroscopic choline:creatine ratios. These findings support the idea that peripheral immune responses are linked to cognitive dysfunction during advanced HIV-1 disease.",
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AB - The relationship between monocyte immune responses and cognitive impairment during progressive human immunodeficiency virus type 1 (HIV-1) infection was investigated in 28 subjects receiving highly active antiretroviral therapy. The mean ± SEM CD4+ T lymphocyte count and virus load for all patients were 237 ± 41 cells/mm3 and 77,091 ± 195,372 HIV-1 RNA copies/mL, respectively. Levels of soluble tumor necrosis factor-α type II receptor (sTNF-RII) and soluble CD14 (sCD14) were measured in plasma by ELISA and were correlated with results from neuropsychological, magnetic resonance imaging, and magnetic resonance spectroscopy tests. Plasma sCD14 and sTNF-RII levels were elevated in subjects with cognitive impairment and in those with brain atrophy. Furthermore, both factors were correlated with spectroscopic choline:creatine ratios. These findings support the idea that peripheral immune responses are linked to cognitive dysfunction during advanced HIV-1 disease.

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