Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study

Dominique S. Michaud, Jacques Izard, Charlotte S. Wilhelm-Benartzi, Doo Ho You, Verena A. Grote, Anne Tjønneland, Christina C. Dahm, Kim Overvad, Mazda Jenab, Veronika Fedirko, Marie Christine Boutron-Ruault, Françoise Clavel-Chapelon, Antoine Racine, Rudolf Kaaks, Heiner Boeing, Jana Foerster, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Carlotta SacerdoteSabina Sieri, Domenico Palli, Rosario Tumino, Salvatore Panico, Peter D. Siersema, Petra H.M. Peeters, Eiliv Lund, Aurelio Barricarte, José María Huerta, Esther Molina-Montes, Miren Dorronsoro, J. Ramón Quirós, Eric J. Duell, Weimin Ye, Malin Sund, Björn Lindkvist, Dorthe Johansen, Kay Tee Khaw, Nick Wareham, Ruth C. Travis, Paolo Vineis, H. Bas Bueno-De-Mesquita, Elio Riboli

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Objective: Examine the relationship between antibodies to 25 oral bacteria and pancreatic cancer risk in a prospective cohort study. Design We measured antibodies to oral bacteria in prediagnosis blood samples from 405 pancreatic cancer cases and 416 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition study. Analyses were conducted using conditional logistic regression and additionally adjusted for smoking status and body mass index. Results: Individuals with high levels of antibodies against Porphyromonas gingivalis ATTC 53978, a pathogenic periodontal bacteria, had a twofold higher risk of pancreatic cancer than individuals with lower levels of these antibodies (OR 2.14; 95% CI 1.05 to 4.36; >200 ng/ml vs ≤200 ng/ml). To explore the association with commensal (non-pathogenic) oral bacteria, we performed a cluster analysis and identified two groups of individuals, based on their antibody profiles. A cluster with overall higher levels of antibodies had a 45% lower risk of pancreatic cancer than a cluster with overall lower levels of antibodies (OR 0.55; 95% CI 0.36 to 0.83). Conclusions: Periodontal disease might increase the risk for pancreatic cancer. Moreover, increased levels of antibodies against specific commensal oral bacteria, which can inhibit growth of pathogenic bacteria, might reduce the risk of pancreatic cancer. Studies are needed to determine whether oral bacteria have direct effects on pancreatic cancer pathogenesis or serve as markers of the immune response.

Original languageEnglish (US)
Pages (from-to)1764-1770
Number of pages7
JournalGut
Volume62
Issue number12
DOIs
StatePublished - Dec 1 2013

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Pancreatic Neoplasms
Cohort Studies
Prospective Studies
Bacteria
Antibodies
Porphyromonas gingivalis
Mouth Neoplasms
Periodontal Diseases
Cluster Analysis
Body Mass Index
Biomarkers
Logistic Models
Smoking
Growth
Neoplasms

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Michaud, D. S., Izard, J., Wilhelm-Benartzi, C. S., You, D. H., Grote, V. A., Tjønneland, A., ... Riboli, E. (2013). Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study. Gut, 62(12), 1764-1770. https://doi.org/10.1136/gutjnl-2012-303006

Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study. / Michaud, Dominique S.; Izard, Jacques; Wilhelm-Benartzi, Charlotte S.; You, Doo Ho; Grote, Verena A.; Tjønneland, Anne; Dahm, Christina C.; Overvad, Kim; Jenab, Mazda; Fedirko, Veronika; Boutron-Ruault, Marie Christine; Clavel-Chapelon, Françoise; Racine, Antoine; Kaaks, Rudolf; Boeing, Heiner; Foerster, Jana; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Sacerdote, Carlotta; Sieri, Sabina; Palli, Domenico; Tumino, Rosario; Panico, Salvatore; Siersema, Peter D.; Peeters, Petra H.M.; Lund, Eiliv; Barricarte, Aurelio; Huerta, José María; Molina-Montes, Esther; Dorronsoro, Miren; Ramón Quirós, J.; Duell, Eric J.; Ye, Weimin; Sund, Malin; Lindkvist, Björn; Johansen, Dorthe; Khaw, Kay Tee; Wareham, Nick; Travis, Ruth C.; Vineis, Paolo; Bas Bueno-De-Mesquita, H.; Riboli, Elio.

In: Gut, Vol. 62, No. 12, 01.12.2013, p. 1764-1770.

Research output: Contribution to journalArticle

Michaud, DS, Izard, J, Wilhelm-Benartzi, CS, You, DH, Grote, VA, Tjønneland, A, Dahm, CC, Overvad, K, Jenab, M, Fedirko, V, Boutron-Ruault, MC, Clavel-Chapelon, F, Racine, A, Kaaks, R, Boeing, H, Foerster, J, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Sacerdote, C, Sieri, S, Palli, D, Tumino, R, Panico, S, Siersema, PD, Peeters, PHM, Lund, E, Barricarte, A, Huerta, JM, Molina-Montes, E, Dorronsoro, M, Ramón Quirós, J, Duell, EJ, Ye, W, Sund, M, Lindkvist, B, Johansen, D, Khaw, KT, Wareham, N, Travis, RC, Vineis, P, Bas Bueno-De-Mesquita, H & Riboli, E 2013, 'Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study', Gut, vol. 62, no. 12, pp. 1764-1770. https://doi.org/10.1136/gutjnl-2012-303006
Michaud, Dominique S. ; Izard, Jacques ; Wilhelm-Benartzi, Charlotte S. ; You, Doo Ho ; Grote, Verena A. ; Tjønneland, Anne ; Dahm, Christina C. ; Overvad, Kim ; Jenab, Mazda ; Fedirko, Veronika ; Boutron-Ruault, Marie Christine ; Clavel-Chapelon, Françoise ; Racine, Antoine ; Kaaks, Rudolf ; Boeing, Heiner ; Foerster, Jana ; Trichopoulou, Antonia ; Lagiou, Pagona ; Trichopoulos, Dimitrios ; Sacerdote, Carlotta ; Sieri, Sabina ; Palli, Domenico ; Tumino, Rosario ; Panico, Salvatore ; Siersema, Peter D. ; Peeters, Petra H.M. ; Lund, Eiliv ; Barricarte, Aurelio ; Huerta, José María ; Molina-Montes, Esther ; Dorronsoro, Miren ; Ramón Quirós, J. ; Duell, Eric J. ; Ye, Weimin ; Sund, Malin ; Lindkvist, Björn ; Johansen, Dorthe ; Khaw, Kay Tee ; Wareham, Nick ; Travis, Ruth C. ; Vineis, Paolo ; Bas Bueno-De-Mesquita, H. ; Riboli, Elio. / Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study. In: Gut. 2013 ; Vol. 62, No. 12. pp. 1764-1770.
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abstract = "Objective: Examine the relationship between antibodies to 25 oral bacteria and pancreatic cancer risk in a prospective cohort study. Design We measured antibodies to oral bacteria in prediagnosis blood samples from 405 pancreatic cancer cases and 416 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition study. Analyses were conducted using conditional logistic regression and additionally adjusted for smoking status and body mass index. Results: Individuals with high levels of antibodies against Porphyromonas gingivalis ATTC 53978, a pathogenic periodontal bacteria, had a twofold higher risk of pancreatic cancer than individuals with lower levels of these antibodies (OR 2.14; 95{\%} CI 1.05 to 4.36; >200 ng/ml vs ≤200 ng/ml). To explore the association with commensal (non-pathogenic) oral bacteria, we performed a cluster analysis and identified two groups of individuals, based on their antibody profiles. A cluster with overall higher levels of antibodies had a 45{\%} lower risk of pancreatic cancer than a cluster with overall lower levels of antibodies (OR 0.55; 95{\%} CI 0.36 to 0.83). Conclusions: Periodontal disease might increase the risk for pancreatic cancer. Moreover, increased levels of antibodies against specific commensal oral bacteria, which can inhibit growth of pathogenic bacteria, might reduce the risk of pancreatic cancer. Studies are needed to determine whether oral bacteria have direct effects on pancreatic cancer pathogenesis or serve as markers of the immune response.",
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T1 - Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study

AU - Michaud, Dominique S.

AU - Izard, Jacques

AU - Wilhelm-Benartzi, Charlotte S.

AU - You, Doo Ho

AU - Grote, Verena A.

AU - Tjønneland, Anne

AU - Dahm, Christina C.

AU - Overvad, Kim

AU - Jenab, Mazda

AU - Fedirko, Veronika

AU - Boutron-Ruault, Marie Christine

AU - Clavel-Chapelon, Françoise

AU - Racine, Antoine

AU - Kaaks, Rudolf

AU - Boeing, Heiner

AU - Foerster, Jana

AU - Trichopoulou, Antonia

AU - Lagiou, Pagona

AU - Trichopoulos, Dimitrios

AU - Sacerdote, Carlotta

AU - Sieri, Sabina

AU - Palli, Domenico

AU - Tumino, Rosario

AU - Panico, Salvatore

AU - Siersema, Peter D.

AU - Peeters, Petra H.M.

AU - Lund, Eiliv

AU - Barricarte, Aurelio

AU - Huerta, José María

AU - Molina-Montes, Esther

AU - Dorronsoro, Miren

AU - Ramón Quirós, J.

AU - Duell, Eric J.

AU - Ye, Weimin

AU - Sund, Malin

AU - Lindkvist, Björn

AU - Johansen, Dorthe

AU - Khaw, Kay Tee

AU - Wareham, Nick

AU - Travis, Ruth C.

AU - Vineis, Paolo

AU - Bas Bueno-De-Mesquita, H.

AU - Riboli, Elio

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Objective: Examine the relationship between antibodies to 25 oral bacteria and pancreatic cancer risk in a prospective cohort study. Design We measured antibodies to oral bacteria in prediagnosis blood samples from 405 pancreatic cancer cases and 416 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition study. Analyses were conducted using conditional logistic regression and additionally adjusted for smoking status and body mass index. Results: Individuals with high levels of antibodies against Porphyromonas gingivalis ATTC 53978, a pathogenic periodontal bacteria, had a twofold higher risk of pancreatic cancer than individuals with lower levels of these antibodies (OR 2.14; 95% CI 1.05 to 4.36; >200 ng/ml vs ≤200 ng/ml). To explore the association with commensal (non-pathogenic) oral bacteria, we performed a cluster analysis and identified two groups of individuals, based on their antibody profiles. A cluster with overall higher levels of antibodies had a 45% lower risk of pancreatic cancer than a cluster with overall lower levels of antibodies (OR 0.55; 95% CI 0.36 to 0.83). Conclusions: Periodontal disease might increase the risk for pancreatic cancer. Moreover, increased levels of antibodies against specific commensal oral bacteria, which can inhibit growth of pathogenic bacteria, might reduce the risk of pancreatic cancer. Studies are needed to determine whether oral bacteria have direct effects on pancreatic cancer pathogenesis or serve as markers of the immune response.

AB - Objective: Examine the relationship between antibodies to 25 oral bacteria and pancreatic cancer risk in a prospective cohort study. Design We measured antibodies to oral bacteria in prediagnosis blood samples from 405 pancreatic cancer cases and 416 matched controls, nested within the European Prospective Investigation into Cancer and Nutrition study. Analyses were conducted using conditional logistic regression and additionally adjusted for smoking status and body mass index. Results: Individuals with high levels of antibodies against Porphyromonas gingivalis ATTC 53978, a pathogenic periodontal bacteria, had a twofold higher risk of pancreatic cancer than individuals with lower levels of these antibodies (OR 2.14; 95% CI 1.05 to 4.36; >200 ng/ml vs ≤200 ng/ml). To explore the association with commensal (non-pathogenic) oral bacteria, we performed a cluster analysis and identified two groups of individuals, based on their antibody profiles. A cluster with overall higher levels of antibodies had a 45% lower risk of pancreatic cancer than a cluster with overall lower levels of antibodies (OR 0.55; 95% CI 0.36 to 0.83). Conclusions: Periodontal disease might increase the risk for pancreatic cancer. Moreover, increased levels of antibodies against specific commensal oral bacteria, which can inhibit growth of pathogenic bacteria, might reduce the risk of pancreatic cancer. Studies are needed to determine whether oral bacteria have direct effects on pancreatic cancer pathogenesis or serve as markers of the immune response.

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