Plant sterols alter bile acid metabolism and reduce cholesterol absorption in hamsters fed a beef-based diet

Timothy P Carr, Roxana M. Cornelison, Blake J. Illston, Cindy L. Stuefer-Powell, Daniel D. Gallaher

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

This study examined the cholesterol-lowering properties of dietary plants sterols (PS) when consumed in a beef-based diet. Male Syrian hamsters were fed freeze-dried ground beef supplemented with maltodextrin, vegetable oil, vitamins, minerals, and soybean sterol esters at 0.0, 0.3, 1.0, or 3.0% sterol by weight of the diet. After 4 weeks, plasma and liver total cholesterol concentrations were significantly and incrementally reduced at all levels of dietary PS tested compared to no dietary PS. Cholesterol absorption was also significantly reduced by dietary PS, resulting in greater fecal excretion of neutral steroids. Total bile acid excretion was also significantly increased with PS feeding. A novel finding in the present study was that PS feeding caused an alteration in the gallbladder bile acid profile, resulting in a significantly lower hydrophobicity index. The present study demonstrates that the consumption of ground beef containing PS can significantly lower plasma cholesterol concentration at relatively low doses, indicating that ground beef can be used as a functional food to lower cholesterol while providing superior nutritional benefits over the high fat PS-containing margarines and salad dressings currently available.

Original languageEnglish (US)
Pages (from-to)745-754
Number of pages10
JournalNutrition Research
Volume22
Issue number6
DOIs
StatePublished - Jun 29 2002

Fingerprint

Phytosterols
Bile Acids and Salts
Cricetinae
Cholesterol
Diet
Sterols
Margarine
Functional Food
Plant Oils
Red Meat
Mesocricetus
Bandages
Gallbladder
Hydrophobic and Hydrophilic Interactions
Soybeans
Vitamins
Minerals
Esters
Fats
Steroids

Keywords

  • Bile acids
  • Cholesterol absorption
  • Dietary beef
  • Hamsters
  • Plants sterols

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Plant sterols alter bile acid metabolism and reduce cholesterol absorption in hamsters fed a beef-based diet. / Carr, Timothy P; Cornelison, Roxana M.; Illston, Blake J.; Stuefer-Powell, Cindy L.; Gallaher, Daniel D.

In: Nutrition Research, Vol. 22, No. 6, 29.06.2002, p. 745-754.

Research output: Contribution to journalArticle

Carr, Timothy P ; Cornelison, Roxana M. ; Illston, Blake J. ; Stuefer-Powell, Cindy L. ; Gallaher, Daniel D. / Plant sterols alter bile acid metabolism and reduce cholesterol absorption in hamsters fed a beef-based diet. In: Nutrition Research. 2002 ; Vol. 22, No. 6. pp. 745-754.
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