Plant sphingolipid metabolism and function

Kyle D. Luttgeharm, Athen N. Kimberlin, Edgar B. Cahoon

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Sphingolipids, a once overlooked class of lipids in plants, are now recognized as abundant and essential components of plasma membrane and other endomembranes of plant cells. In addition to providing structural integrity to plant membranes, sphingolipids contribute to Golgi trafficking and protein organizational domains in the plasma membrane. Sphingolipid metabolites have also been linked to the regulation of cellular processes, including programmed cell death. Advances in mass spectrometry-based sphingolipid profiling and analyses of Arabidopsis mutants have enabled fundamental discoveries in sphingolipid structural diversity, metabolism, and function that are reviewed here. These discoveries are laying the groundwork for the tailoring of sphingolipid biosynthesis and catabolism for improved tolerance of plants to biotic and abiotic stresses.

Original languageEnglish (US)
Pages (from-to)249-286
Number of pages38
JournalSubcellular Biochemistry
Volume86
DOIs
StatePublished - Mar 1 2016

Fingerprint

Sphingolipids
Metabolism
Cell membranes
Cell Membrane
Biosynthesis
Plant Cells
Structural integrity
Cell death
Metabolites
Arabidopsis
Mass spectrometry
Mass Spectrometry
Cell Death
Membranes
Lipids
Proteins

Keywords

  • Ceramide
  • Lipid rafts
  • Lipid-signaling
  • Long-chain bases
  • Plasma membrane
  • Programed cell death
  • Sphingolipid

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology
  • Cancer Research

Cite this

Plant sphingolipid metabolism and function. / Luttgeharm, Kyle D.; Kimberlin, Athen N.; Cahoon, Edgar B.

In: Subcellular Biochemistry, Vol. 86, 01.03.2016, p. 249-286.

Research output: Contribution to journalArticle

Luttgeharm, Kyle D. ; Kimberlin, Athen N. ; Cahoon, Edgar B. / Plant sphingolipid metabolism and function. In: Subcellular Biochemistry. 2016 ; Vol. 86. pp. 249-286.
@article{e8b35a87068a4d8ba203ab755262a462,
title = "Plant sphingolipid metabolism and function",
abstract = "Sphingolipids, a once overlooked class of lipids in plants, are now recognized as abundant and essential components of plasma membrane and other endomembranes of plant cells. In addition to providing structural integrity to plant membranes, sphingolipids contribute to Golgi trafficking and protein organizational domains in the plasma membrane. Sphingolipid metabolites have also been linked to the regulation of cellular processes, including programmed cell death. Advances in mass spectrometry-based sphingolipid profiling and analyses of Arabidopsis mutants have enabled fundamental discoveries in sphingolipid structural diversity, metabolism, and function that are reviewed here. These discoveries are laying the groundwork for the tailoring of sphingolipid biosynthesis and catabolism for improved tolerance of plants to biotic and abiotic stresses.",
keywords = "Ceramide, Lipid rafts, Lipid-signaling, Long-chain bases, Plasma membrane, Programed cell death, Sphingolipid",
author = "Luttgeharm, {Kyle D.} and Kimberlin, {Athen N.} and Cahoon, {Edgar B.}",
year = "2016",
month = "3",
day = "1",
doi = "10.1007/978-3-319-25979-6_11",
language = "English (US)",
volume = "86",
pages = "249--286",
journal = "Sub-Cellular Biochemistry",
issn = "0306-0225",
publisher = "Plenum Publishers",

}

TY - JOUR

T1 - Plant sphingolipid metabolism and function

AU - Luttgeharm, Kyle D.

AU - Kimberlin, Athen N.

AU - Cahoon, Edgar B.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Sphingolipids, a once overlooked class of lipids in plants, are now recognized as abundant and essential components of plasma membrane and other endomembranes of plant cells. In addition to providing structural integrity to plant membranes, sphingolipids contribute to Golgi trafficking and protein organizational domains in the plasma membrane. Sphingolipid metabolites have also been linked to the regulation of cellular processes, including programmed cell death. Advances in mass spectrometry-based sphingolipid profiling and analyses of Arabidopsis mutants have enabled fundamental discoveries in sphingolipid structural diversity, metabolism, and function that are reviewed here. These discoveries are laying the groundwork for the tailoring of sphingolipid biosynthesis and catabolism for improved tolerance of plants to biotic and abiotic stresses.

AB - Sphingolipids, a once overlooked class of lipids in plants, are now recognized as abundant and essential components of plasma membrane and other endomembranes of plant cells. In addition to providing structural integrity to plant membranes, sphingolipids contribute to Golgi trafficking and protein organizational domains in the plasma membrane. Sphingolipid metabolites have also been linked to the regulation of cellular processes, including programmed cell death. Advances in mass spectrometry-based sphingolipid profiling and analyses of Arabidopsis mutants have enabled fundamental discoveries in sphingolipid structural diversity, metabolism, and function that are reviewed here. These discoveries are laying the groundwork for the tailoring of sphingolipid biosynthesis and catabolism for improved tolerance of plants to biotic and abiotic stresses.

KW - Ceramide

KW - Lipid rafts

KW - Lipid-signaling

KW - Long-chain bases

KW - Plasma membrane

KW - Programed cell death

KW - Sphingolipid

UR - http://www.scopus.com/inward/record.url?scp=84962473579&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962473579&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-25979-6_11

DO - 10.1007/978-3-319-25979-6_11

M3 - Article

C2 - 27023239

AN - SCOPUS:84962473579

VL - 86

SP - 249

EP - 286

JO - Sub-Cellular Biochemistry

JF - Sub-Cellular Biochemistry

SN - 0306-0225

ER -