Pinealectomy decelerates the circadian food intake rhythm of cervically sympathectomized rabbits

A. C. Bobbert, H. Duindam, J. J. Riethoven

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Long-term records of the free-running food intake rhythms were obtained from 26 young adult blinded rabbits that were subjected in the course of recording to bilateral superior cervical ganglionectomy (sympathectomy). This always resulted in acceleration of the rhythm (mean λ r= - 0.35 h). Some 4 months afterwards, 12 rabbits were pinealectomized and after another 4 months sham pinealectomized also. In the other 14 animals, these operations were performed in the reverse order. It appeared that suctioning away part of the ventricular walls during sham pinealectomy was followed by a slight reduction in r (mean = - 0.07 h) that could be largely attributed to the spontaneous gradual reduction of r that occurred throughout all experiments. On the other hand, total pinealectomy in these already sympathectomized blinded rabbits always resulted in a substantial deceleration of the rhythms (mean λ r = + 0.23 h). These observations on blinded rabbits suggest that a sympathetically denervated pineal gland releases appreciable amounts of melatonin or of another hormone with a melatonin-like accelerating effect on the circadian pacemaker (SCN).

Original languageEnglish (US)
Pages (from-to)297-309
Number of pages13
JournalChronobiology International
Volume9
Issue number4
DOIs
StatePublished - Jan 1 1992

Fingerprint

food intake
Eating
rabbits
Rabbits
melatonin
Melatonin
Ganglionectomy
pineal body
Sympathectomy
Pineal Gland
Deceleration
young adults
Running
Young Adult
hormones
Hormones
pinealectomy
animals

Keywords

  • Aging
  • Food intake rhythm
  • Free-running period
  • Melatonin
  • Pineal gland
  • Pinealectomy
  • Rabbit
  • Superior cervical ganglia

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Pinealectomy decelerates the circadian food intake rhythm of cervically sympathectomized rabbits. / Bobbert, A. C.; Duindam, H.; Riethoven, J. J.

In: Chronobiology International, Vol. 9, No. 4, 01.01.1992, p. 297-309.

Research output: Contribution to journalArticle

@article{8fc0dd835a094752a566edfb7a24105a,
title = "Pinealectomy decelerates the circadian food intake rhythm of cervically sympathectomized rabbits",
abstract = "Long-term records of the free-running food intake rhythms were obtained from 26 young adult blinded rabbits that were subjected in the course of recording to bilateral superior cervical ganglionectomy (sympathectomy). This always resulted in acceleration of the rhythm (mean λ r= - 0.35 h). Some 4 months afterwards, 12 rabbits were pinealectomized and after another 4 months sham pinealectomized also. In the other 14 animals, these operations were performed in the reverse order. It appeared that suctioning away part of the ventricular walls during sham pinealectomy was followed by a slight reduction in r (mean = - 0.07 h) that could be largely attributed to the spontaneous gradual reduction of r that occurred throughout all experiments. On the other hand, total pinealectomy in these already sympathectomized blinded rabbits always resulted in a substantial deceleration of the rhythms (mean λ r = + 0.23 h). These observations on blinded rabbits suggest that a sympathetically denervated pineal gland releases appreciable amounts of melatonin or of another hormone with a melatonin-like accelerating effect on the circadian pacemaker (SCN).",
keywords = "Aging, Food intake rhythm, Free-running period, Melatonin, Pineal gland, Pinealectomy, Rabbit, Superior cervical ganglia",
author = "Bobbert, {A. C.} and H. Duindam and Riethoven, {J. J.}",
year = "1992",
month = "1",
day = "1",
doi = "10.3109/07420529209064539",
language = "English (US)",
volume = "9",
pages = "297--309",
journal = "Chronobiology International",
issn = "0742-0528",
publisher = "Informa Healthcare",
number = "4",

}

TY - JOUR

T1 - Pinealectomy decelerates the circadian food intake rhythm of cervically sympathectomized rabbits

AU - Bobbert, A. C.

AU - Duindam, H.

AU - Riethoven, J. J.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - Long-term records of the free-running food intake rhythms were obtained from 26 young adult blinded rabbits that were subjected in the course of recording to bilateral superior cervical ganglionectomy (sympathectomy). This always resulted in acceleration of the rhythm (mean λ r= - 0.35 h). Some 4 months afterwards, 12 rabbits were pinealectomized and after another 4 months sham pinealectomized also. In the other 14 animals, these operations were performed in the reverse order. It appeared that suctioning away part of the ventricular walls during sham pinealectomy was followed by a slight reduction in r (mean = - 0.07 h) that could be largely attributed to the spontaneous gradual reduction of r that occurred throughout all experiments. On the other hand, total pinealectomy in these already sympathectomized blinded rabbits always resulted in a substantial deceleration of the rhythms (mean λ r = + 0.23 h). These observations on blinded rabbits suggest that a sympathetically denervated pineal gland releases appreciable amounts of melatonin or of another hormone with a melatonin-like accelerating effect on the circadian pacemaker (SCN).

AB - Long-term records of the free-running food intake rhythms were obtained from 26 young adult blinded rabbits that were subjected in the course of recording to bilateral superior cervical ganglionectomy (sympathectomy). This always resulted in acceleration of the rhythm (mean λ r= - 0.35 h). Some 4 months afterwards, 12 rabbits were pinealectomized and after another 4 months sham pinealectomized also. In the other 14 animals, these operations were performed in the reverse order. It appeared that suctioning away part of the ventricular walls during sham pinealectomy was followed by a slight reduction in r (mean = - 0.07 h) that could be largely attributed to the spontaneous gradual reduction of r that occurred throughout all experiments. On the other hand, total pinealectomy in these already sympathectomized blinded rabbits always resulted in a substantial deceleration of the rhythms (mean λ r = + 0.23 h). These observations on blinded rabbits suggest that a sympathetically denervated pineal gland releases appreciable amounts of melatonin or of another hormone with a melatonin-like accelerating effect on the circadian pacemaker (SCN).

KW - Aging

KW - Food intake rhythm

KW - Free-running period

KW - Melatonin

KW - Pineal gland

KW - Pinealectomy

KW - Rabbit

KW - Superior cervical ganglia

UR - http://www.scopus.com/inward/record.url?scp=0026909140&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026909140&partnerID=8YFLogxK

U2 - 10.3109/07420529209064539

DO - 10.3109/07420529209064539

M3 - Article

C2 - 1423738

AN - SCOPUS:0026909140

VL - 9

SP - 297

EP - 309

JO - Chronobiology International

JF - Chronobiology International

SN - 0742-0528

IS - 4

ER -