Phytopathogen type III effector weaponry and their plant targets

Anna Block, Guangyong Li, Zheng Qing Fu, James R. Alfano

Research output: Contribution to journalReview article

200 Citations (Scopus)

Abstract

Phytopathogenic bacteria suppress plant innate immunity and promote pathogenesis by injecting proteins called type III effectors into plant cells using a type III protein secretion system. These type III effectors use at least three strategies to alter host responses. One strategy is to alter host protein turnover, either by direct cleavage or by modulating ubiquitination and targeting the 26S proteasome. Another strategy involves alteration of RNA metabolism by transcriptional activation or ADP-ribosylation of RNA-binding proteins. A third major strategy is to inhibit the kinases involved in plant defence signaling, either by the removal of phosphates or by direct inhibition. The wide array of strategies that bacterial pathogens employ to suppress innate immunity suggest that circumvention of innate immunity is crucial for bacterial pathogenicity of plants.

Original languageEnglish (US)
Pages (from-to)396-403
Number of pages8
JournalCurrent Opinion in Plant Biology
Volume11
Issue number4
DOIs
StatePublished - Aug 1 2008

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plant pathogens
plant pathogenic bacteria
RNA-binding proteins
protein secretion
proteasome endopeptidase complex
transcriptional activation
protein metabolism
phosphotransferases (kinases)
pathogenicity
pathogenesis
RNA
phosphates
metabolism
pathogens
innate immunity
proteins
cells

ASJC Scopus subject areas

  • Plant Science

Cite this

Phytopathogen type III effector weaponry and their plant targets. / Block, Anna; Li, Guangyong; Fu, Zheng Qing; Alfano, James R.

In: Current Opinion in Plant Biology, Vol. 11, No. 4, 01.08.2008, p. 396-403.

Research output: Contribution to journalReview article

Block, Anna ; Li, Guangyong ; Fu, Zheng Qing ; Alfano, James R. / Phytopathogen type III effector weaponry and their plant targets. In: Current Opinion in Plant Biology. 2008 ; Vol. 11, No. 4. pp. 396-403.
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