Physiological proteomics of heart failure

James O'Reilly, Merry L Lindsey, John A. Baugh

Research output: Contribution to journalReview article

Abstract

Heart failure (HF) is a complex clinical syndrome that is predominantly the result of coronary artery disease and hypertension. Despite advances in the treatment of myocardial infarction and HF, mortality has remained unchanged for several decades with approximately 50% of patients dying within five years of HF diagnosis. Recent statistics project a 46% increase in the incidence of HF by 2030, largely due to increases in the aging population and the prevalence of metabolic disorders such as obesity and diabetes. To develop diagnostic and prognostic biomarkers and effective therapies for the prevention, diagnosis, and treatment of HF, it is crucial that we improve our understanding of the complex pathophysiology of this disease. Advances in proteomic techniques are providing a means to map disease-specific alterations in the expression, location, and post-translational modification of proteins at the level of whole tissues, primary cells, and the extracellular matrix. The objective of this review is to summarize the evolving proteomics techniques and discuss recent data that has successfully used proteomic analysis to reveal new biomarkers, map functional networks that may drive disease progression, and identify potential therapeutic targets for HF.

Original languageEnglish (US)
Pages (from-to)185-197
Number of pages13
JournalCurrent Opinion in Physiology
Volume1
DOIs
StatePublished - Feb 1 2018
Externally publishedYes

Fingerprint

Proteomics
Heart Failure
Biomarkers
Post Translational Protein Processing
Treatment Failure
Extracellular Matrix
Disease Progression
Coronary Artery Disease
Therapeutics
Obesity
Myocardial Infarction
Hypertension
Mortality
Incidence
Population

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Physiological proteomics of heart failure. / O'Reilly, James; Lindsey, Merry L; Baugh, John A.

In: Current Opinion in Physiology, Vol. 1, 01.02.2018, p. 185-197.

Research output: Contribution to journalReview article

O'Reilly, James ; Lindsey, Merry L ; Baugh, John A. / Physiological proteomics of heart failure. In: Current Opinion in Physiology. 2018 ; Vol. 1. pp. 185-197.
@article{0bfed7606cc94fe290e51cdc51300ef6,
title = "Physiological proteomics of heart failure",
abstract = "Heart failure (HF) is a complex clinical syndrome that is predominantly the result of coronary artery disease and hypertension. Despite advances in the treatment of myocardial infarction and HF, mortality has remained unchanged for several decades with approximately 50{\%} of patients dying within five years of HF diagnosis. Recent statistics project a 46{\%} increase in the incidence of HF by 2030, largely due to increases in the aging population and the prevalence of metabolic disorders such as obesity and diabetes. To develop diagnostic and prognostic biomarkers and effective therapies for the prevention, diagnosis, and treatment of HF, it is crucial that we improve our understanding of the complex pathophysiology of this disease. Advances in proteomic techniques are providing a means to map disease-specific alterations in the expression, location, and post-translational modification of proteins at the level of whole tissues, primary cells, and the extracellular matrix. The objective of this review is to summarize the evolving proteomics techniques and discuss recent data that has successfully used proteomic analysis to reveal new biomarkers, map functional networks that may drive disease progression, and identify potential therapeutic targets for HF.",
author = "James O'Reilly and Lindsey, {Merry L} and Baugh, {John A.}",
year = "2018",
month = "2",
day = "1",
doi = "10.1016/j.cophys.2017.12.010",
language = "English (US)",
volume = "1",
pages = "185--197",
journal = "Current Opinion in Physiology",
issn = "2468-8681",
publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Physiological proteomics of heart failure

AU - O'Reilly, James

AU - Lindsey, Merry L

AU - Baugh, John A.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Heart failure (HF) is a complex clinical syndrome that is predominantly the result of coronary artery disease and hypertension. Despite advances in the treatment of myocardial infarction and HF, mortality has remained unchanged for several decades with approximately 50% of patients dying within five years of HF diagnosis. Recent statistics project a 46% increase in the incidence of HF by 2030, largely due to increases in the aging population and the prevalence of metabolic disorders such as obesity and diabetes. To develop diagnostic and prognostic biomarkers and effective therapies for the prevention, diagnosis, and treatment of HF, it is crucial that we improve our understanding of the complex pathophysiology of this disease. Advances in proteomic techniques are providing a means to map disease-specific alterations in the expression, location, and post-translational modification of proteins at the level of whole tissues, primary cells, and the extracellular matrix. The objective of this review is to summarize the evolving proteomics techniques and discuss recent data that has successfully used proteomic analysis to reveal new biomarkers, map functional networks that may drive disease progression, and identify potential therapeutic targets for HF.

AB - Heart failure (HF) is a complex clinical syndrome that is predominantly the result of coronary artery disease and hypertension. Despite advances in the treatment of myocardial infarction and HF, mortality has remained unchanged for several decades with approximately 50% of patients dying within five years of HF diagnosis. Recent statistics project a 46% increase in the incidence of HF by 2030, largely due to increases in the aging population and the prevalence of metabolic disorders such as obesity and diabetes. To develop diagnostic and prognostic biomarkers and effective therapies for the prevention, diagnosis, and treatment of HF, it is crucial that we improve our understanding of the complex pathophysiology of this disease. Advances in proteomic techniques are providing a means to map disease-specific alterations in the expression, location, and post-translational modification of proteins at the level of whole tissues, primary cells, and the extracellular matrix. The objective of this review is to summarize the evolving proteomics techniques and discuss recent data that has successfully used proteomic analysis to reveal new biomarkers, map functional networks that may drive disease progression, and identify potential therapeutic targets for HF.

UR - http://www.scopus.com/inward/record.url?scp=85051009179&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85051009179&partnerID=8YFLogxK

U2 - 10.1016/j.cophys.2017.12.010

DO - 10.1016/j.cophys.2017.12.010

M3 - Review article

VL - 1

SP - 185

EP - 197

JO - Current Opinion in Physiology

JF - Current Opinion in Physiology

SN - 2468-8681

ER -