Physics and imaging for targeting of oligometastases

Fang Fang Yin, Shiva Das, John Kirkpatrick, Mark Oldham, Zhiheng Wang, Su Min Zhou

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Oligometastases refer to metastases that are limited in number and location and are amenable to regional treatment. The majority of these metastases appear in the brain, lung, liver, and bone. Although the focus of interest in the past within radiation oncology has been on the treatment of intracranial metastases, there has been growing interest in extracranial sites such as the liver and lung. This is largely because of the rapid development of targeting techniques for oligometastases such as intensity-modulated and image-guided radiation therapy, which has made it possible to deliver single or a few fractions of high-dose radiation treatments, highly conformal to the target. The clinical decision to use radiation to treat oligometastases is based on both radiobiological and physics considerations. The radiobiological considerations involve improvement of treatment schema for time, dose, and volume. Areas of interests are hypofractionation, tumor and normal tissue tolerance, and hypoxia. The physics considerations for oligometastases treatment are focused mainly on ensuring treatment accuracy and precision. This article discusses the physics and imaging aspects involved in each step of the radiation treatment process for oligometastases, including target definition, treatment simulation, treatment planning, pretreatment target localization, radiation delivery, treatment verification, and treatment evaluation.

Original languageEnglish (US)
Pages (from-to)85-101
Number of pages17
JournalSeminars in Radiation Oncology
Volume16
Issue number2
DOIs
StatePublished - Apr 2006

Fingerprint

Physics
physics
metastasis
Therapeutics
Radiation
radiation
Neoplasm Metastasis
liver
lungs
Image-Guided Radiotherapy
dosage
Lung
Radiation Oncology
Liver
hypoxia
pretreatment
bones
brain
planning
radiation therapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Physics and imaging for targeting of oligometastases. / Yin, Fang Fang; Das, Shiva; Kirkpatrick, John; Oldham, Mark; Wang, Zhiheng; Zhou, Su Min.

In: Seminars in Radiation Oncology, Vol. 16, No. 2, 04.2006, p. 85-101.

Research output: Contribution to journalArticle

Yin, Fang Fang ; Das, Shiva ; Kirkpatrick, John ; Oldham, Mark ; Wang, Zhiheng ; Zhou, Su Min. / Physics and imaging for targeting of oligometastases. In: Seminars in Radiation Oncology. 2006 ; Vol. 16, No. 2. pp. 85-101.
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