Physical feature encoding and word recognition abilities are altered in children with intractable epilepsy

Preliminary neuromagnetic evidence

Maria Pardos, Milena Korostenskaja, Jing Xiang, Hisako Fujiwara, Ki H. Lee, Paul S. Horn, Anna Byars, Jennifer Vannest, Yingying Wang, Nat Hemasilpin, Douglas F. Rose

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective evaluation of language function is critical for children with intractable epilepsy under consideration for epilepsy surgery. The purpose of this preliminary study was to evaluate word recognition in children with intractable epilepsy by using magnetoencephalography (MEG). Ten children with intractable epilepsy (M/F 6/4, mean ± SD 13.4 ± 2.2 years) were matched on age and sex to healthy controls. Common nouns were presented simultaneously from visual and auditory sensory inputs in "match" and "mismatch" conditions. Neuromagnetic responses M1, M2, M3, M4, and M5 with latencies of 100 ms, 150 ms, 250 ms, 350 ms, and 450 ms, respectively, elicited during the "match" condition were identified. Compared to healthy children, epilepsy patients had both significantly delayed latency of the M1 and reduced amplitudes of M3 and M5 responses. These results provide neurophysiologic evidence of altered word recognition in children with intractable epilepsy.

Original languageEnglish (US)
Article number237436
JournalBehavioural Neurology
Volume2015
DOIs
StatePublished - Jan 1 2015

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Aptitude
Epilepsy
Magnetoencephalography
Language
Drug Resistant Epilepsy

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neurology
  • Clinical Neurology

Cite this

Physical feature encoding and word recognition abilities are altered in children with intractable epilepsy : Preliminary neuromagnetic evidence. / Pardos, Maria; Korostenskaja, Milena; Xiang, Jing; Fujiwara, Hisako; Lee, Ki H.; Horn, Paul S.; Byars, Anna; Vannest, Jennifer; Wang, Yingying; Hemasilpin, Nat; Rose, Douglas F.

In: Behavioural Neurology, Vol. 2015, 237436, 01.01.2015.

Research output: Contribution to journalArticle

Pardos, M, Korostenskaja, M, Xiang, J, Fujiwara, H, Lee, KH, Horn, PS, Byars, A, Vannest, J, Wang, Y, Hemasilpin, N & Rose, DF 2015, 'Physical feature encoding and word recognition abilities are altered in children with intractable epilepsy: Preliminary neuromagnetic evidence', Behavioural Neurology, vol. 2015, 237436. https://doi.org/10.1155/2015/237436
Pardos, Maria ; Korostenskaja, Milena ; Xiang, Jing ; Fujiwara, Hisako ; Lee, Ki H. ; Horn, Paul S. ; Byars, Anna ; Vannest, Jennifer ; Wang, Yingying ; Hemasilpin, Nat ; Rose, Douglas F. / Physical feature encoding and word recognition abilities are altered in children with intractable epilepsy : Preliminary neuromagnetic evidence. In: Behavioural Neurology. 2015 ; Vol. 2015.
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