Phycodnaviruses: A peek at genetic diversity

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

The family Phycodnaviridae encompasses a diverse collection of large icosahedral, dsDNA viruses infecting algae. These viruses have genomes ranging from 160 to 560 kb. The family consists of six genera based initially on host range and supported by sequence comparisons. The family is monophyletic with branches for each genus, but the phycodnaviruses have evolutionary roots that connect with several other families of large DNA viruses, referred to as the nucleocytoplasmic large DNA viruses (NCLDV). The genomes of members in three genera in the Phycodnaviridae have recently been sequenced and the purpose of this manuscript is to summarize these data. The viruses have diverse genome structures, some with large regions of non-coding sequence and others with regions of single-stranded DNA. Typically, phycodnaviruses have the coding capacity for hundreds of genes. The genome analyses have revealed in excess of 1000 unique genes, with only 14 homologous genes held in common among the three genera of the phycodnavirses sequenced to date. Thus, the gene diversity far exceeds the number of so-called "core" genes. Little is known about the replication of these viruses, but the consequences of these infections of the phytoplankton have global affects, including altered geochemical cycling and weather patterns.

Original languageEnglish (US)
Pages (from-to)119-132
Number of pages14
JournalVirus Research
Volume117
Issue number1
DOIs
StatePublished - Apr 2006

Fingerprint

Phycodnaviridae
Genome
DNA Viruses
Genes
Viruses
Phytoplankton
Host Specificity
Single-Stranded DNA
Weather
Virus Diseases

Keywords

  • Algae
  • Evolution
  • Genetic diversity
  • Genome
  • Nucleocytoplasmic large DNA virus
  • Phycodnavirus

ASJC Scopus subject areas

  • Cancer Research
  • Virology
  • Infectious Diseases

Cite this

Phycodnaviruses : A peek at genetic diversity. / Dunigan, David D.; Fitzgerald, Lisa A.; Van Etten, James L.

In: Virus Research, Vol. 117, No. 1, 04.2006, p. 119-132.

Research output: Contribution to journalArticle

Dunigan, David D. ; Fitzgerald, Lisa A. ; Van Etten, James L. / Phycodnaviruses : A peek at genetic diversity. In: Virus Research. 2006 ; Vol. 117, No. 1. pp. 119-132.
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