Photosensitized formation of 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in DNA by riboflavin.

H. Kasai, Z. Yamaizumi, F. Yamamoto, T. Bessho, S. Nishimura, M. Berger, J. Cadet

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Potosensitized formation of 8-hydroxyguanine in DNA by riboflavin was observed. A reaction mechanism involving guanine radical cation and hydration reaction was proposed. This hypothesis was confirmed by the incorporation of [18O]-atom within guanine moiety in isotopic experiments using [18O]-H2O. Photosensitized formation of oh8Gua by riboflavin was also observed in cellular DNA.

Original languageEnglish (US)
Pages (from-to)181-182
Number of pages2
JournalNucleic acids symposium series
Issue number27
StatePublished - 1992

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Riboflavin
Guanine
DNA
Cations
8-hydroxyguanine
7,8-dihydro-8-oxoguanine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kasai, H., Yamaizumi, Z., Yamamoto, F., Bessho, T., Nishimura, S., Berger, M., & Cadet, J. (1992). Photosensitized formation of 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in DNA by riboflavin. Nucleic acids symposium series, (27), 181-182.

Photosensitized formation of 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in DNA by riboflavin. / Kasai, H.; Yamaizumi, Z.; Yamamoto, F.; Bessho, T.; Nishimura, S.; Berger, M.; Cadet, J.

In: Nucleic acids symposium series, No. 27, 1992, p. 181-182.

Research output: Contribution to journalArticle

Kasai, H, Yamaizumi, Z, Yamamoto, F, Bessho, T, Nishimura, S, Berger, M & Cadet, J 1992, 'Photosensitized formation of 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in DNA by riboflavin.', Nucleic acids symposium series, no. 27, pp. 181-182.
Kasai, H. ; Yamaizumi, Z. ; Yamamoto, F. ; Bessho, T. ; Nishimura, S. ; Berger, M. ; Cadet, J. / Photosensitized formation of 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in DNA by riboflavin. In: Nucleic acids symposium series. 1992 ; No. 27. pp. 181-182.
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