Photosensitized formation of 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in DNA by riboflavin.

H. Kasai, Z. Yamaizumi, F. Yamamoto, T. Bessho, S. Nishimura, M. Berger, J. Cadet

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Abstract

Potosensitized formation of 8-hydroxyguanine in DNA by riboflavin was observed. A reaction mechanism involving guanine radical cation and hydration reaction was proposed. This hypothesis was confirmed by the incorporation of [18O]-atom within guanine moiety in isotopic experiments using [18O]-H2O. Photosensitized formation of oh8Gua by riboflavin was also observed in cellular DNA.

Original languageEnglish (US)
Pages (from-to)181-182
Number of pages2
JournalNucleic acids symposium series
Issue number27
StatePublished - 1992

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ASJC Scopus subject areas

  • Medicine(all)

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Kasai, H., Yamaizumi, Z., Yamamoto, F., Bessho, T., Nishimura, S., Berger, M., & Cadet, J. (1992). Photosensitized formation of 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in DNA by riboflavin. Nucleic acids symposium series, (27), 181-182.