Phosphinate-containing rhodol and fluorescein scaffolds for the development of bioprobes

Yuan Fang, Gillian N. Good, Xinqi Zhou, Cliff I. Stains

Research output: Contribution to journalArticle

Abstract

A series of phosphinate-containing rhodol and fluorescein dyes are disclosed. These new fluorophores increase the color palette of phosphinate-based xanthenes in the far-red spectral region. The new chemical functionality of these scaffolds is leveraged to produce a sensitive, no-wash imaging probe for cellular esterase activity. The reported phosphinate-containing dyes provide platforms for the further development of imaging probes and self-reporting delivery vehicles.

Original languageEnglish (US)
Pages (from-to)5962-5965
Number of pages4
JournalChemical Communications
Volume55
Issue number42
DOIs
StatePublished - Jan 1 2019

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Fluorescein
Scaffolds
Coloring Agents
Xanthenes
Dyes
Imaging techniques
Fluorophores
Esterases
Color

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Phosphinate-containing rhodol and fluorescein scaffolds for the development of bioprobes. / Fang, Yuan; Good, Gillian N.; Zhou, Xinqi; Stains, Cliff I.

In: Chemical Communications, Vol. 55, No. 42, 01.01.2019, p. 5962-5965.

Research output: Contribution to journalArticle

Fang, Yuan ; Good, Gillian N. ; Zhou, Xinqi ; Stains, Cliff I. / Phosphinate-containing rhodol and fluorescein scaffolds for the development of bioprobes. In: Chemical Communications. 2019 ; Vol. 55, No. 42. pp. 5962-5965.
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