Philadelphia-chromosome-positive pre-B-cell leukemia presenting as blast crisis of chronic myelogenous leukemia

L. B. Vogler, W. M. Crist, P. C. Vinson, A. Sarrif, Michael G Brattain, M. S. Coleman

Research output: Contribution to journalArticle

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Abstract

Cytogenetic studies of chronic myelogenous leukemia (CML) have shown that the majority of hemopoietic cells originate from pluripotential stem cells affected in this disease. Evidence that lymphocytes are also progeny of these stem cells, however, has been indirect. Philadelphia chromosome-positive leukemic blasts from a 4 10/ 12 yr old boy with CML in blast crisis had features characteristic of pre-B leukemic cells, including expression of cytoplasmic IgM and absence of surface immunoglobulin. Additional immunologic, enzymatic, and pharmacologic characterization of these cells supported their pre-B-cell phenotype. Together, these features provide direct evidence for CML stem cell ancestry to lymphocytes of the B-cell lineage.

Original languageEnglish (US)
Pages (from-to)1164-1170
Number of pages7
JournalBlood
Volume54
Issue number5
StatePublished - Dec 1 1979

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Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Blast Crisis
Philadelphia Chromosome
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Chromosomes
Stem cells
B-Lymphoid Precursor Cells
Stem Cells
Lymphocytes
Cells
B-Cell Antigen Receptors
Cell Lineage
Cytogenetics
Immunoglobulin M
B-Lymphocytes
Phenotype

ASJC Scopus subject areas

  • Hematology

Cite this

Vogler, L. B., Crist, W. M., Vinson, P. C., Sarrif, A., Brattain, M. G., & Coleman, M. S. (1979). Philadelphia-chromosome-positive pre-B-cell leukemia presenting as blast crisis of chronic myelogenous leukemia. Blood, 54(5), 1164-1170.

Philadelphia-chromosome-positive pre-B-cell leukemia presenting as blast crisis of chronic myelogenous leukemia. / Vogler, L. B.; Crist, W. M.; Vinson, P. C.; Sarrif, A.; Brattain, Michael G; Coleman, M. S.

In: Blood, Vol. 54, No. 5, 01.12.1979, p. 1164-1170.

Research output: Contribution to journalArticle

Vogler, LB, Crist, WM, Vinson, PC, Sarrif, A, Brattain, MG & Coleman, MS 1979, 'Philadelphia-chromosome-positive pre-B-cell leukemia presenting as blast crisis of chronic myelogenous leukemia', Blood, vol. 54, no. 5, pp. 1164-1170.
Vogler LB, Crist WM, Vinson PC, Sarrif A, Brattain MG, Coleman MS. Philadelphia-chromosome-positive pre-B-cell leukemia presenting as blast crisis of chronic myelogenous leukemia. Blood. 1979 Dec 1;54(5):1164-1170.
Vogler, L. B. ; Crist, W. M. ; Vinson, P. C. ; Sarrif, A. ; Brattain, Michael G ; Coleman, M. S. / Philadelphia-chromosome-positive pre-B-cell leukemia presenting as blast crisis of chronic myelogenous leukemia. In: Blood. 1979 ; Vol. 54, No. 5. pp. 1164-1170.
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