Phenobarbital-Induced Fatty Livers in the Rat

Michael Floyd Sorrell, D. J. Tuma, J. K. Noffsinger, A. J. Barak

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Administration of phenobarbital to rats fed a standard laboratory diet or 6 different synthetic diets produced elevated levels of triglyceride, phospholipid and total cholesterol in the livers of these animals. By varying the choline, fat, and protein constituents in these diets it appears that choline and fat content are factors influencing the amount of triglyceride accumulating in livers as a result of phenobarbital administration. These dietary factors, however, did not appear to regulate the manner in which phenobarbital elevated phospholipid and total cholesterol levels.

Original languageEnglish (US)
Pages (from-to)839-843
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume143
Issue number3
DOIs
StatePublished - Jul 1973

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Fatty Liver
Phenobarbital
Nutrition
Liver
Rats
Choline
Phospholipids
Triglycerides
Fats
Cholesterol
Diet
Formulated Food
Animals
Proteins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Phenobarbital-Induced Fatty Livers in the Rat. / Sorrell, Michael Floyd; Tuma, D. J.; Noffsinger, J. K.; Barak, A. J.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 143, No. 3, 07.1973, p. 839-843.

Research output: Contribution to journalArticle

Sorrell, Michael Floyd ; Tuma, D. J. ; Noffsinger, J. K. ; Barak, A. J. / Phenobarbital-Induced Fatty Livers in the Rat. In: Proceedings of the Society for Experimental Biology and Medicine. 1973 ; Vol. 143, No. 3. pp. 839-843.
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