Pharmacological approaches to prevent abdominal aortic aneurysm enlargement and rupture

Mark Rentschler, Bernard Timothy Baxter

Research output: Chapter in Book/Report/Conference proceedingConference contribution

19 Scopus citations

Abstract

Current efforts to limit the mortality from abdominal aortic aneurysm (AAA) are dependent on detection and elective repair. Even by conservative estimates, there are more than 300,000 undetected AAAs in the United States, most of which are small and would not require immediate intervention. Current practice following detection of a small AAA includes education, risk factor management, and serial observation. This approach, based on the statistical probability of death from rupture compared to the morbidity and mortality of repair, can be unsettling to patients and lead to a decline in perceived quality of life. While the pathophysiology of AAA is not completely understood, observations from human tissues and animal studies have identified a number of potential targets for inhibiting aneurysm expansion. It is clear that the prominent inflammatory response identified in aneurysm tissue has a role in promoting aortic expansion. This inflammatory response is thought to account for increased expression of proteolytic enzymes. Recent work has suggested a unifying hypothesis centered on the MAP kinase family affecting both the regulation of matrix synthesis and the expression of proteolytic enzymes. The tetracycline antibiotics and antihypertensive medications that affect the angiotensin-converting enzyme system can inhibit proteolysis. There are adequate preliminary data to support a large prospective randomized trial of doxycycline to prevent aneurysm expansion.

Original languageEnglish (US)
Title of host publicationThe Abdominal Aortic Aneurysm
Subtitle of host publicationGenetics, Pathophysiology, and Molecular Biology
PublisherBlackwell Publishing Inc.
Pages39-46
Number of pages8
ISBN (Print)1573316571, 9781573316576
DOIs
Publication statusPublished - Nov 2006

Publication series

NameAnnals of the New York Academy of Sciences
Volume1085
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

    Fingerprint

Keywords

  • Aneurysm
  • Tetracycline

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Rentschler, M., & Baxter, B. T. (2006). Pharmacological approaches to prevent abdominal aortic aneurysm enlargement and rupture. In The Abdominal Aortic Aneurysm: Genetics, Pathophysiology, and Molecular Biology (pp. 39-46). (Annals of the New York Academy of Sciences; Vol. 1085). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1383.003