Pharmacokinetics of darunavir/ritonavir with etravirine both twice daily in human immunodeficiency virus-infected adolescents and young adults

for the IMPAACT P1058A Team

Research output: Contribution to journalArticle

Abstract

Data on the combination of darunavir/ritonavir and etravirine both given twice daily in adolescents/young adults are lacking. In this study, we assessed the pharmacokinetics of darunavir/ ritonavir 600/100 mg with etravirine 200 mg twice daily in 36 treatment-experienced human immunodeficiency virus-infected adolescents and young adults and found that exposures were comparable to those reported in adults.

Original languageEnglish (US)
Pages (from-to)294-296
Number of pages3
JournalJournal of the Pediatric Infectious Diseases Society
Volume6
Issue number3
DOIs
StatePublished - Sep 1 2017

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etravirine
Ritonavir
Young Adult
Pharmacokinetics
HIV
Darunavir
Therapeutics

Keywords

  • Antiretrovirals
  • Darunavir
  • Etravirine
  • Pediatrics
  • Ritonavir

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases

Cite this

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title = "Pharmacokinetics of darunavir/ritonavir with etravirine both twice daily in human immunodeficiency virus-infected adolescents and young adults",
abstract = "Data on the combination of darunavir/ritonavir and etravirine both given twice daily in adolescents/young adults are lacking. In this study, we assessed the pharmacokinetics of darunavir/ ritonavir 600/100 mg with etravirine 200 mg twice daily in 36 treatment-experienced human immunodeficiency virus-infected adolescents and young adults and found that exposures were comparable to those reported in adults.",
keywords = "Antiretrovirals, Darunavir, Etravirine, Pediatrics, Ritonavir",
author = "{for the IMPAACT P1058A Team} and Cressey, {Tim R.} and Ram Yogev and Andrew Wiznia and Rohan Hazra and Patrick Jean-Philippe and Bobbie Graham and Amy Gonzalez and Paula Britto and Carey, {Vincent J.} and Fletcher, {Courtney V} and Acosta, {Edward P.}",
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T1 - Pharmacokinetics of darunavir/ritonavir with etravirine both twice daily in human immunodeficiency virus-infected adolescents and young adults

AU - for the IMPAACT P1058A Team

AU - Cressey, Tim R.

AU - Yogev, Ram

AU - Wiznia, Andrew

AU - Hazra, Rohan

AU - Jean-Philippe, Patrick

AU - Graham, Bobbie

AU - Gonzalez, Amy

AU - Britto, Paula

AU - Carey, Vincent J.

AU - Fletcher, Courtney V

AU - Acosta, Edward P.

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Data on the combination of darunavir/ritonavir and etravirine both given twice daily in adolescents/young adults are lacking. In this study, we assessed the pharmacokinetics of darunavir/ ritonavir 600/100 mg with etravirine 200 mg twice daily in 36 treatment-experienced human immunodeficiency virus-infected adolescents and young adults and found that exposures were comparable to those reported in adults.

AB - Data on the combination of darunavir/ritonavir and etravirine both given twice daily in adolescents/young adults are lacking. In this study, we assessed the pharmacokinetics of darunavir/ ritonavir 600/100 mg with etravirine 200 mg twice daily in 36 treatment-experienced human immunodeficiency virus-infected adolescents and young adults and found that exposures were comparable to those reported in adults.

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KW - Etravirine

KW - Pediatrics

KW - Ritonavir

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