Pharmacokinetics of bisphenol a released from a dental sealant

Eric Y.K. Fung, Nels O. Ewoldsen, Henry A. St. Germain, David B. Marx, Chang Ling Miaw, Chakwan Siew, Hwai Nan Chou, Stephen E. Gruninger, Daniel M. Meyer

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Abstract

Background. Limited information is available regarding potentially estrogenic bisphenol A, or BPA, released from dental sealants. This study determined the rate-and time-course of BPA released from a dental sealant (Delton Opaque Light-cure Pit and Fissure Sealant, Preventive Care/Dentsply) when applied at a dosage of 8 milligrams (one tooth) or 32 mg (8 mg on each of four teeth) to 40 healthy adults. Methods. The authors recruited 40 healthy subjects (18 men and 22 women, 20-55 years of age) who did not have histories of pit and fissure sealant placement or composite resin restorations. The authors collected saliva (30 milliliters) and blood (7 mL) specimens from all subjects immediately before sealant placement (baseline) and at one hour, three hours, one day, three days and five days after sealant placement. They used high-pressure liquid chromatography to determine BPA (detection sensitivity 5 parts per billion, or ppb) in all specimens. Results. The authors detected BPA in some saliva specimens (5.8-105.6 ppb) collected at one hour and three hours. The BPA, however, was not detectable beyond three hours or in any of the serum specimens. For the one-and three-hour saliva samples, the BPA concentration in the high-dose (32 mg) group was significantly greater than in the low-dose (8 mg) group (P < .05, Wilcoxon signed rank test). In the high-dose group, there was a significant decrease in saliva BPA concentrations from one hour to three hours (P < .01, Wilcoxon signed rank test). Conclusion. This study showed that BPA released orally from a dental sealant may not be absorbed or may be present in nondetectable amounts in systemic circulation. The concern about potential estrogenicity of sealant may be unfounded.

Original languageEnglish (US)
Pages (from-to)51-58
Number of pages8
JournalJournal of the American Dental Association
Volume131
Issue number1
DOIs
Publication statusPublished - Jan 2000

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ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Fung, E. Y. K., Ewoldsen, N. O., St. Germain, H. A., Marx, D. B., Miaw, C. L., Siew, C., ... Meyer, D. M. (2000). Pharmacokinetics of bisphenol a released from a dental sealant. Journal of the American Dental Association, 131(1), 51-58. https://doi.org/10.14219/jada.archive.2000.0019