Pharmacokinetics of bisphenol a released from a dental sealant

Eric Y.K. Fung, Nels O. Ewoldsen, Henry A. St. Germain, David B. Marx, Chang Ling Miaw, Chakwan Siew, Hwai Nan Chou, Stephen E. Gruninger, Daniel M. Meyer

Research output: Contribution to journalArticle

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Abstract

Background. Limited information is available regarding potentially estrogenic bisphenol A, or BPA, released from dental sealants. This study determined the rate-and time-course of BPA released from a dental sealant (Delton Opaque Light-cure Pit and Fissure Sealant, Preventive Care/Dentsply) when applied at a dosage of 8 milligrams (one tooth) or 32 mg (8 mg on each of four teeth) to 40 healthy adults. Methods. The authors recruited 40 healthy subjects (18 men and 22 women, 20-55 years of age) who did not have histories of pit and fissure sealant placement or composite resin restorations. The authors collected saliva (30 milliliters) and blood (7 mL) specimens from all subjects immediately before sealant placement (baseline) and at one hour, three hours, one day, three days and five days after sealant placement. They used high-pressure liquid chromatography to determine BPA (detection sensitivity 5 parts per billion, or ppb) in all specimens. Results. The authors detected BPA in some saliva specimens (5.8-105.6 ppb) collected at one hour and three hours. The BPA, however, was not detectable beyond three hours or in any of the serum specimens. For the one-and three-hour saliva samples, the BPA concentration in the high-dose (32 mg) group was significantly greater than in the low-dose (8 mg) group (P < .05, Wilcoxon signed rank test). In the high-dose group, there was a significant decrease in saliva BPA concentrations from one hour to three hours (P < .01, Wilcoxon signed rank test). Conclusion. This study showed that BPA released orally from a dental sealant may not be absorbed or may be present in nondetectable amounts in systemic circulation. The concern about potential estrogenicity of sealant may be unfounded.

Original languageEnglish (US)
Pages (from-to)51-58
Number of pages8
JournalJournal of the American Dental Association
Volume131
Issue number1
DOIs
StatePublished - Jan 2000

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Pit and Fissure Sealants
Saliva
Pharmacokinetics
Nonparametric Statistics
Tooth
Bisphenol A-Glycidyl Methacrylate
Preventive Medicine
Composite Resins
Healthy Volunteers
High Pressure Liquid Chromatography
Light
Serum

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Fung, E. Y. K., Ewoldsen, N. O., St. Germain, H. A., Marx, D. B., Miaw, C. L., Siew, C., ... Meyer, D. M. (2000). Pharmacokinetics of bisphenol a released from a dental sealant. Journal of the American Dental Association, 131(1), 51-58. https://doi.org/10.14219/jada.archive.2000.0019

Pharmacokinetics of bisphenol a released from a dental sealant. / Fung, Eric Y.K.; Ewoldsen, Nels O.; St. Germain, Henry A.; Marx, David B.; Miaw, Chang Ling; Siew, Chakwan; Chou, Hwai Nan; Gruninger, Stephen E.; Meyer, Daniel M.

In: Journal of the American Dental Association, Vol. 131, No. 1, 01.2000, p. 51-58.

Research output: Contribution to journalArticle

Fung, EYK, Ewoldsen, NO, St. Germain, HA, Marx, DB, Miaw, CL, Siew, C, Chou, HN, Gruninger, SE & Meyer, DM 2000, 'Pharmacokinetics of bisphenol a released from a dental sealant', Journal of the American Dental Association, vol. 131, no. 1, pp. 51-58. https://doi.org/10.14219/jada.archive.2000.0019
Fung, Eric Y.K. ; Ewoldsen, Nels O. ; St. Germain, Henry A. ; Marx, David B. ; Miaw, Chang Ling ; Siew, Chakwan ; Chou, Hwai Nan ; Gruninger, Stephen E. ; Meyer, Daniel M. / Pharmacokinetics of bisphenol a released from a dental sealant. In: Journal of the American Dental Association. 2000 ; Vol. 131, No. 1. pp. 51-58.
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abstract = "Background. Limited information is available regarding potentially estrogenic bisphenol A, or BPA, released from dental sealants. This study determined the rate-and time-course of BPA released from a dental sealant (Delton Opaque Light-cure Pit and Fissure Sealant, Preventive Care/Dentsply) when applied at a dosage of 8 milligrams (one tooth) or 32 mg (8 mg on each of four teeth) to 40 healthy adults. Methods. The authors recruited 40 healthy subjects (18 men and 22 women, 20-55 years of age) who did not have histories of pit and fissure sealant placement or composite resin restorations. The authors collected saliva (30 milliliters) and blood (7 mL) specimens from all subjects immediately before sealant placement (baseline) and at one hour, three hours, one day, three days and five days after sealant placement. They used high-pressure liquid chromatography to determine BPA (detection sensitivity 5 parts per billion, or ppb) in all specimens. Results. The authors detected BPA in some saliva specimens (5.8-105.6 ppb) collected at one hour and three hours. The BPA, however, was not detectable beyond three hours or in any of the serum specimens. For the one-and three-hour saliva samples, the BPA concentration in the high-dose (32 mg) group was significantly greater than in the low-dose (8 mg) group (P < .05, Wilcoxon signed rank test). In the high-dose group, there was a significant decrease in saliva BPA concentrations from one hour to three hours (P < .01, Wilcoxon signed rank test). Conclusion. This study showed that BPA released orally from a dental sealant may not be absorbed or may be present in nondetectable amounts in systemic circulation. The concern about potential estrogenicity of sealant may be unfounded.",
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AU - Fung, Eric Y.K.

AU - Ewoldsen, Nels O.

AU - St. Germain, Henry A.

AU - Marx, David B.

AU - Miaw, Chang Ling

AU - Siew, Chakwan

AU - Chou, Hwai Nan

AU - Gruninger, Stephen E.

AU - Meyer, Daniel M.

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N2 - Background. Limited information is available regarding potentially estrogenic bisphenol A, or BPA, released from dental sealants. This study determined the rate-and time-course of BPA released from a dental sealant (Delton Opaque Light-cure Pit and Fissure Sealant, Preventive Care/Dentsply) when applied at a dosage of 8 milligrams (one tooth) or 32 mg (8 mg on each of four teeth) to 40 healthy adults. Methods. The authors recruited 40 healthy subjects (18 men and 22 women, 20-55 years of age) who did not have histories of pit and fissure sealant placement or composite resin restorations. The authors collected saliva (30 milliliters) and blood (7 mL) specimens from all subjects immediately before sealant placement (baseline) and at one hour, three hours, one day, three days and five days after sealant placement. They used high-pressure liquid chromatography to determine BPA (detection sensitivity 5 parts per billion, or ppb) in all specimens. Results. The authors detected BPA in some saliva specimens (5.8-105.6 ppb) collected at one hour and three hours. The BPA, however, was not detectable beyond three hours or in any of the serum specimens. For the one-and three-hour saliva samples, the BPA concentration in the high-dose (32 mg) group was significantly greater than in the low-dose (8 mg) group (P < .05, Wilcoxon signed rank test). In the high-dose group, there was a significant decrease in saliva BPA concentrations from one hour to three hours (P < .01, Wilcoxon signed rank test). Conclusion. This study showed that BPA released orally from a dental sealant may not be absorbed or may be present in nondetectable amounts in systemic circulation. The concern about potential estrogenicity of sealant may be unfounded.

AB - Background. Limited information is available regarding potentially estrogenic bisphenol A, or BPA, released from dental sealants. This study determined the rate-and time-course of BPA released from a dental sealant (Delton Opaque Light-cure Pit and Fissure Sealant, Preventive Care/Dentsply) when applied at a dosage of 8 milligrams (one tooth) or 32 mg (8 mg on each of four teeth) to 40 healthy adults. Methods. The authors recruited 40 healthy subjects (18 men and 22 women, 20-55 years of age) who did not have histories of pit and fissure sealant placement or composite resin restorations. The authors collected saliva (30 milliliters) and blood (7 mL) specimens from all subjects immediately before sealant placement (baseline) and at one hour, three hours, one day, three days and five days after sealant placement. They used high-pressure liquid chromatography to determine BPA (detection sensitivity 5 parts per billion, or ppb) in all specimens. Results. The authors detected BPA in some saliva specimens (5.8-105.6 ppb) collected at one hour and three hours. The BPA, however, was not detectable beyond three hours or in any of the serum specimens. For the one-and three-hour saliva samples, the BPA concentration in the high-dose (32 mg) group was significantly greater than in the low-dose (8 mg) group (P < .05, Wilcoxon signed rank test). In the high-dose group, there was a significant decrease in saliva BPA concentrations from one hour to three hours (P < .01, Wilcoxon signed rank test). Conclusion. This study showed that BPA released orally from a dental sealant may not be absorbed or may be present in nondetectable amounts in systemic circulation. The concern about potential estrogenicity of sealant may be unfounded.

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