Pharmacokinetics and acute renal effects of continuously infused carboplatin

Daryl J. Murry, John T. Sandlund, Lisa M. Stricklin, John H. Rodman

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Abstract

Carboplatin was given as a 24‐hour infusion at high doses to pediatric patients with cancer (n = 11) and pharmacokinetic parameters and renal effects were determined. Median carboplatin clearance for course 1 (151 ml/min per 1.73 m2;) was not significantly different from clearance for course 2 (144 ml/min per 1.73 m2; p = 0.33). The median glomerular filtration rate measured before (159 ml/min per 1.73 m2) and after course 1 (161 ml/min per 1.73 m2) did not differ significantly (p = 0.4). Binding was time dependent but modest with a median free fraction at the end of infusion of 0.82. Pharmacokinetic parameters for continuous‐infusion carboplatin are similar to those reported for short infusions, but the median dose of 817 mg/m2 required to achieve an acceptable systemic exposure in these patients was 45% greater than the previously suggested maximum tolerated dosage. Continuous infusion carboplatin did not alter carboplatin clearance or adversely effect glomerular filtration rate during a second course, showing the feasibility of this alternative dosage strategy to enhance therapeutic effects. Clinical Pharmacology and Therapeutics (1993) 54, 374–380; doi:

Original languageEnglish (US)
Pages (from-to)374-380
Number of pages7
JournalClinical Pharmacology & Therapeutics
Volume54
Issue number4
DOIs
StatePublished - Oct 1993

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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