PGI2 attenuates baroreflex control of renal nerve activity by a vagal mechanism

Irving H Zucker, M. J. Panzenbeck, S. Barker, W. Tan, M. A. Hajdu

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The present study was undertaken to determine whether left circumflex coronary artery (ic) administration of prostacyclin (PIG2) caused an inhibition of the baroreflex control of renal sympathetic nerve activity (RSNA). RSNA was recorded in 12 dogs. Baroreflex sensitivity of RSNA was assessed by infusion of either sodium nitroprusside or phenylephrine and by determining the slope of the mean arterial pressure-RSNA relationship. During nitroprusside infusion, intracoronary PGI2 depressed the baroreflex sensitivity by nearly 90% compared with intracoronary tris(hydroxy-methyl)aminomethane (Tris) (P < 0.002). In addition, the peak increase in RSNA during nitroprusside infusion was significantly inhibited during intracoronary PGI2 (57.9 ± 6.4 vs. 21.2 ± 3.0 spikes/s, P < 0.05). There was no significant difference in the inhibition of RSNA during phenylephrine infusion when intracoronary PGI2 was compared with Tris. Both bilateral vagotomy and pericoronary lidocaine blocked the inhibitory effects of PGI2 on the baroreflex increase in RSNA. It is concluded from these data that exogenously administered PGI2 stimulates or sensitizes afferent endings within the supply of the left circumflex coronary artery to inhibit the baroreflex control of RSNA during evoked hypotension. These afferents traverse vagal pathways via the pericoronary nerves. The role of endogenous prostaglandins in modulation of baroreflex function via a cardiac reflex remains to be elucidated.

Original languageEnglish (US)
Pages (from-to)R424-R430
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume254
Issue number3 (23/3)
StatePublished - Jan 1 1988

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Baroreflex
Epoprostenol
Kidney
Nitroprusside
Phenylephrine
Coronary Vessels
Vagotomy
Lidocaine
Hypotension
Prostaglandins
Reflex
Arterial Pressure
Dogs

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

PGI2 attenuates baroreflex control of renal nerve activity by a vagal mechanism. / Zucker, Irving H; Panzenbeck, M. J.; Barker, S.; Tan, W.; Hajdu, M. A.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 254, No. 3 (23/3), 01.01.1988, p. R424-R430.

Research output: Contribution to journalArticle

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