PGE2 and arachidonate inhibit the baroreflex in conscious dogs via cardiac receptors.

M. J. Panzenbeck, W. Tan, M. A. Hajdu, K. G. Cornish, Irving H Zucker

Research output: Contribution to journalArticle

Abstract

Prostaglandin (PG) I2 and PGE2 are known to stimulate left ventricular receptors with nonmyelinated vagal afferents. The present experiments were performed to determine the effects of intracoronary infusion of PGE2 (10-50 ng.kg-1.min-1) and arachidonic acid (50-100 micrograms.kg-1.min-1) on the baroreflex control of heart rate in conscious dogs. Dogs were anesthetized with pentobarbital sodium and were instrumented using sterile surgical techniques. After recovery, baroreflex pressure-heart rate curves were constructed by varying arterial pressure with partial occlusions of the descending aorta or inferior vena cava. Intracoronary infusion of PGE2 significantly inhibited the maximum heart rate achieved during unloading of baroreceptors, attenuated the heart rate range, and decreased the maximum slope of the baroreflex curve; PGE2 had no significant effect on the minimum heart rate during hypertension. Intravenous infusion of PGE2 did not cause significant baroreflex inhibition, and pericoronary nerve block in three dogs prevented the effects of intracoronary PGE2. Intracoronary infusion of arachidonic acid had effects on the baroreflex control of heart rate similar to those of PGE2. The effects of arachidonic acid infusion were prevented by cyclooxygenase blockade. Thus intracoronary PGE2 and arachidonic acid inhibit the baroreflex control of heart rate most likely via stimulation of left ventricular receptors with vagal C-fiber afferents. The effects of arachidonic acid were secondary to synthesis of prostaglandins.

Original languageEnglish (US)
JournalThe American journal of physiology
Volume256
Issue number4 Pt 2
StatePublished - Apr 1989

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Baroreflex
Dinoprostone
Dogs
Heart Rate
Arachidonic Acid
Unmyelinated Nerve Fibers
Pressoreceptors
Nerve Block
Inferior Vena Cava
Epoprostenol
Pentobarbital
Prostaglandin-Endoperoxide Synthases
Thoracic Aorta
Intravenous Infusions
Prostaglandins
Arterial Pressure
Hypertension
Pressure

ASJC Scopus subject areas

  • Medicine(all)

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PGE2 and arachidonate inhibit the baroreflex in conscious dogs via cardiac receptors. / Panzenbeck, M. J.; Tan, W.; Hajdu, M. A.; Cornish, K. G.; Zucker, Irving H.

In: The American journal of physiology, Vol. 256, No. 4 Pt 2, 04.1989.

Research output: Contribution to journalArticle

Panzenbeck, M. J. ; Tan, W. ; Hajdu, M. A. ; Cornish, K. G. ; Zucker, Irving H. / PGE2 and arachidonate inhibit the baroreflex in conscious dogs via cardiac receptors. In: The American journal of physiology. 1989 ; Vol. 256, No. 4 Pt 2.
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