PET study of the distribution of [11C]fluoxetine in a monkey brain

Chyng Yann Shiue, Grace G. Shiue, Kurtis G Cornish, Maria F. O'Rourke

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

No-carrier-added [11C]fluoxetine (2) was synthesized by methylation of norfluoxetine (1) with [11C]H3I in 20% radiochemical yield in a synthesis time of 40 min from EOB with a specific activity of 0.48 Ci/μM (EOB). In vivo study in mouse indicated that the uptake of 2 in mouse tissues was high and the radioactivity remained constant throughout the study. The uptake of 2 in mouse brain was 4%/g. PET study in a Rhesus monkey also showed that the uptakes of 2 in different brain regions were similar and the retention of radioactivity in these regions remained constant throughout the study (80 min). Analysis of arterial plasma by HPLC showed that only 20% of radioactivity in the plasma remained as 2 at 30 min post-injection. These results suggest that the uptake of fluoxetine in monkey brain is probably not receptor mediated. Rather, blood flow, lipophilicity or other transport mechanisms may play a role in its uptake.

Original languageEnglish (US)
Pages (from-to)613-616
Number of pages4
JournalNuclear Medicine and Biology
Volume22
Issue number5
DOIs
StatePublished - Jan 1 1995

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Fluoxetine
Radioactivity
Haplorhini
Brain
Macaca mulatta
Methylation
High Pressure Liquid Chromatography
Injections

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

PET study of the distribution of [11C]fluoxetine in a monkey brain. / Shiue, Chyng Yann; Shiue, Grace G.; Cornish, Kurtis G; O'Rourke, Maria F.

In: Nuclear Medicine and Biology, Vol. 22, No. 5, 01.01.1995, p. 613-616.

Research output: Contribution to journalArticle

Shiue, Chyng Yann ; Shiue, Grace G. ; Cornish, Kurtis G ; O'Rourke, Maria F. / PET study of the distribution of [11C]fluoxetine in a monkey brain. In: Nuclear Medicine and Biology. 1995 ; Vol. 22, No. 5. pp. 613-616.
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