Pesticide use and incident hyperthyroidism in farmers in the Agricultural Health Study

Srishti Shrestha, Christine G. Parks, Whitney S. Goldner, Freya Kamel, David M. Umbach, Mary H. Ward, Catherine C. Lerro, Stella Koutros, Jonathan N. Hofmann, Laura E. Beane Freeman, Dale P. Sandler

Research output: Contribution to journalArticle

Abstract

Background Few studies have evaluated associations between pesticides and hyperthyroidism. Objective We evaluated associations between specific pesticides and incident hyperthyroidism in private pesticide applicators in the Agricultural Health Study. Methods We used Cox proportional hazards models to estimate HRs and 95% CIs for associations between pesticide use at enrolment and hyperthyroidism (n=271) in 35 150 applicators (mostly men), adjusting for potential confounders. Results Ever use of several pesticides (organophosphate insecticide malathion, fungicide maneb/mancozeb, herbicides dicamba, metolachlor, and atrazine in overall sample and chlorimuron ethyl among those ≤62 years) was associated with reduced hyperthyroidism risk, with HRs ranging from 0.50 (95% CI 0.30 to 0.83) for maneb/mancozeb to 0.77 (95% CI 0.59 to 1.00) for atrazine. Hyperthyroidism risk was lowest among those with higher intensity-weighted lifetime days of using carbofuran and chlorpyrifos (p trend ≤0.05). Conclusions Observed associations between pesticides and decreased risk of hyperthyroidism warrant further investigation.

Original languageEnglish (US)
Pages (from-to)332-335
Number of pages4
JournalOccupational and Environmental Medicine
Volume76
Issue number5
DOIs
StatePublished - May 1 2019

Fingerprint

Hyperthyroidism
Pesticides
Maneb
Health
Atrazine
Dicamba
Carbofuran
Malathion
Chlorpyrifos
Organophosphates
Herbicides
Insecticides
Proportional Hazards Models
Farmers

Keywords

  • Agricultural Health Study
  • hyperthyroidism
  • pesticides

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Pesticide use and incident hyperthyroidism in farmers in the Agricultural Health Study. / Shrestha, Srishti; Parks, Christine G.; Goldner, Whitney S.; Kamel, Freya; Umbach, David M.; Ward, Mary H.; Lerro, Catherine C.; Koutros, Stella; Hofmann, Jonathan N.; Beane Freeman, Laura E.; Sandler, Dale P.

In: Occupational and Environmental Medicine, Vol. 76, No. 5, 01.05.2019, p. 332-335.

Research output: Contribution to journalArticle

Shrestha, S, Parks, CG, Goldner, WS, Kamel, F, Umbach, DM, Ward, MH, Lerro, CC, Koutros, S, Hofmann, JN, Beane Freeman, LE & Sandler, DP 2019, 'Pesticide use and incident hyperthyroidism in farmers in the Agricultural Health Study', Occupational and Environmental Medicine, vol. 76, no. 5, pp. 332-335. https://doi.org/10.1136/oemed-2018-105518
Shrestha, Srishti ; Parks, Christine G. ; Goldner, Whitney S. ; Kamel, Freya ; Umbach, David M. ; Ward, Mary H. ; Lerro, Catherine C. ; Koutros, Stella ; Hofmann, Jonathan N. ; Beane Freeman, Laura E. ; Sandler, Dale P. / Pesticide use and incident hyperthyroidism in farmers in the Agricultural Health Study. In: Occupational and Environmental Medicine. 2019 ; Vol. 76, No. 5. pp. 332-335.
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