Persistent neuroinvasive west nile virus infection in an immunocompromised patient

Robert G. Penn, Jeannette Guarner, James J. Sejvar, Herbert Hartman, Rodney D McComb, Diana L. Nevins, Julu Bhatnagar, Sherif R. Zaki

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

A 57-year-old man who had received treatment for B cell lymphoma presented with West Nile virus (WNV) meningoencephalitis. During his 99-day hospitalization, no WNV-specific antibodies were detected. In postmortem central nervous system samples obtained at autopsy, WNV RNA and WNV antigens were detected. This patient's case raises important issues related to the diagnosis, pathogenesis, and possible treatment of persistent WNV infection.

Original languageEnglish (US)
Pages (from-to)680-683
Number of pages4
JournalClinical Infectious Diseases
Volume42
Issue number5
DOIs
StatePublished - Mar 1 2006

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West Nile virus
Immunocompromised Host
Virus Diseases
Meningoencephalitis
B-Cell Lymphoma
Autopsy
Hospitalization
Central Nervous System
RNA
Antigens
Antibodies
Therapeutics

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Penn, R. G., Guarner, J., Sejvar, J. J., Hartman, H., McComb, R. D., Nevins, D. L., ... Zaki, S. R. (2006). Persistent neuroinvasive west nile virus infection in an immunocompromised patient. Clinical Infectious Diseases, 42(5), 680-683. https://doi.org/10.1086/500216

Persistent neuroinvasive west nile virus infection in an immunocompromised patient. / Penn, Robert G.; Guarner, Jeannette; Sejvar, James J.; Hartman, Herbert; McComb, Rodney D; Nevins, Diana L.; Bhatnagar, Julu; Zaki, Sherif R.

In: Clinical Infectious Diseases, Vol. 42, No. 5, 01.03.2006, p. 680-683.

Research output: Contribution to journalArticle

Penn, RG, Guarner, J, Sejvar, JJ, Hartman, H, McComb, RD, Nevins, DL, Bhatnagar, J & Zaki, SR 2006, 'Persistent neuroinvasive west nile virus infection in an immunocompromised patient', Clinical Infectious Diseases, vol. 42, no. 5, pp. 680-683. https://doi.org/10.1086/500216
Penn, Robert G. ; Guarner, Jeannette ; Sejvar, James J. ; Hartman, Herbert ; McComb, Rodney D ; Nevins, Diana L. ; Bhatnagar, Julu ; Zaki, Sherif R. / Persistent neuroinvasive west nile virus infection in an immunocompromised patient. In: Clinical Infectious Diseases. 2006 ; Vol. 42, No. 5. pp. 680-683.
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