Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response

Dawn M. Jelley-Gibbs, John P. Dibble, Deborah M Brown, Tara M. Strutt, K. Kai McKinstry, Susan L. Swain

Research output: Contribution to journalArticle

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Abstract

Encounter with Ag during chronic infections results in the generation of phenotypically and functionally heterogeneous subsets of Ag-specific CD8 T cells. Influenza, an acute infection, results in the generation of similar CD8 T cell heterogeneity, which may be attributed to long-lived depots of flu Ags that stimulate T cell proliferation well after virus clearance. We hypothesized that the heterogeneity of flu-specific CD8 T cells and maintenance of T cell memory required the recruitment of new CD8 T cells to persistent depots of flu Ag, as was the case for flu-specific CD4 T cell responses. However, robust expansion and generation of highly differentiated cytolytic effectors and memory T cells only occurred when naive CD8 T cells were primed during the first week of flu infection. Priming of new naive CD8 T cells after the first week of infection resulted in low numbers of poorly functional effectors, with little to no cytolytic activity, and a negligible contribution to the memory pool. Therefore, although the presentation of flu Ag during the late stages of infection may provide a mechanism for maintaining an activated population of CD8 T cells in the lung, few latecomer CD8 T cells are recruited into the functional memory T cell pool.

Original languageEnglish (US)
Pages (from-to)7563-7570
Number of pages8
JournalJournal of Immunology
Volume178
Issue number12
DOIs
StatePublished - Jun 15 2007

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Human Influenza
T-Lymphocytes
Antigens
Infection
Maintenance
Cell Proliferation
Viruses
Lung

ASJC Scopus subject areas

  • Immunology

Cite this

Jelley-Gibbs, D. M., Dibble, J. P., Brown, D. M., Strutt, T. M., McKinstry, K. K., & Swain, S. L. (2007). Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response. Journal of Immunology, 178(12), 7563-7570. https://doi.org/10.4049/jimmunol.178.12.7563

Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response. / Jelley-Gibbs, Dawn M.; Dibble, John P.; Brown, Deborah M; Strutt, Tara M.; McKinstry, K. Kai; Swain, Susan L.

In: Journal of Immunology, Vol. 178, No. 12, 15.06.2007, p. 7563-7570.

Research output: Contribution to journalArticle

Jelley-Gibbs, DM, Dibble, JP, Brown, DM, Strutt, TM, McKinstry, KK & Swain, SL 2007, 'Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response', Journal of Immunology, vol. 178, no. 12, pp. 7563-7570. https://doi.org/10.4049/jimmunol.178.12.7563
Jelley-Gibbs, Dawn M. ; Dibble, John P. ; Brown, Deborah M ; Strutt, Tara M. ; McKinstry, K. Kai ; Swain, Susan L. / Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response. In: Journal of Immunology. 2007 ; Vol. 178, No. 12. pp. 7563-7570.
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