Persistent behavioral and neurochemical sensitization to an acute injection of methamphetamine following unpredictable stress

Leslie Matuszewich, Samantha Carter, Eden M. Anderson, Ross D. Friedman, Lisa M. McFadden

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Prior research in humans and animals suggest that exposure to chronic stress alters the response to drugs of abuse, increasing vulnerability to drug addiction. Chronic unpredictable stress (CUS) has been shown to augment the increase of dopamine in the striatum when challenged with high doses of methamphetamine immediately following stress exposure, however it is not known whether this neurochemical stress-sensitization continues after the cessation of the stressors or if behavioral sensitization is also present. Therefore, the current study examined the immediate and delayed effects of CUS on methamphetamine-induced behaviors and striatal dopamine levels. Male rats were exposed to 10 days of CUS and then tested in either an open field box to assess locomotion or underwent in vivo microdialysis to measure striatal dopamine levels immediately following CUS or after a 1-2 week delay. All rats exposed to CUS showed a potentiated locomotor response immediately following an acute injection of 7.5. mg/kg methamphetamine compared to non-stressed control rats. Both groups of CUS rats also showed augmented dopamine release and rectal temperatures following methamphetamine with prolonged increases in the CUS rats tested after a delay. These results suggest that CUS increases the sensitivity of a rat to a single injection of methamphetamine and that the increased sensitivity persists for up to 2 weeks following the last stressor.

Original languageEnglish (US)
Pages (from-to)308-313
Number of pages6
JournalBehavioural Brain Research
Volume272
DOIs
StatePublished - Oct 1 2014

Fingerprint

Methamphetamine
Injections
Dopamine
Corpus Striatum
Microdialysis
Street Drugs
Locomotion
Substance-Related Disorders
Temperature
Research

Keywords

  • Dopamine
  • Hyperthermia
  • Locomotion
  • Methamphetamine
  • Microdialysis
  • Sensitization
  • Unpredictable stress

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Persistent behavioral and neurochemical sensitization to an acute injection of methamphetamine following unpredictable stress. / Matuszewich, Leslie; Carter, Samantha; Anderson, Eden M.; Friedman, Ross D.; McFadden, Lisa M.

In: Behavioural Brain Research, Vol. 272, 01.10.2014, p. 308-313.

Research output: Contribution to journalArticle

Matuszewich, Leslie ; Carter, Samantha ; Anderson, Eden M. ; Friedman, Ross D. ; McFadden, Lisa M. / Persistent behavioral and neurochemical sensitization to an acute injection of methamphetamine following unpredictable stress. In: Behavioural Brain Research. 2014 ; Vol. 272. pp. 308-313.
@article{f57ca67b78b4479e95dcff87b5903144,
title = "Persistent behavioral and neurochemical sensitization to an acute injection of methamphetamine following unpredictable stress",
abstract = "Prior research in humans and animals suggest that exposure to chronic stress alters the response to drugs of abuse, increasing vulnerability to drug addiction. Chronic unpredictable stress (CUS) has been shown to augment the increase of dopamine in the striatum when challenged with high doses of methamphetamine immediately following stress exposure, however it is not known whether this neurochemical stress-sensitization continues after the cessation of the stressors or if behavioral sensitization is also present. Therefore, the current study examined the immediate and delayed effects of CUS on methamphetamine-induced behaviors and striatal dopamine levels. Male rats were exposed to 10 days of CUS and then tested in either an open field box to assess locomotion or underwent in vivo microdialysis to measure striatal dopamine levels immediately following CUS or after a 1-2 week delay. All rats exposed to CUS showed a potentiated locomotor response immediately following an acute injection of 7.5. mg/kg methamphetamine compared to non-stressed control rats. Both groups of CUS rats also showed augmented dopamine release and rectal temperatures following methamphetamine with prolonged increases in the CUS rats tested after a delay. These results suggest that CUS increases the sensitivity of a rat to a single injection of methamphetamine and that the increased sensitivity persists for up to 2 weeks following the last stressor.",
keywords = "Dopamine, Hyperthermia, Locomotion, Methamphetamine, Microdialysis, Sensitization, Unpredictable stress",
author = "Leslie Matuszewich and Samantha Carter and Anderson, {Eden M.} and Friedman, {Ross D.} and McFadden, {Lisa M.}",
year = "2014",
month = "10",
day = "1",
doi = "10.1016/j.bbr.2014.07.013",
language = "English (US)",
volume = "272",
pages = "308--313",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",

}

TY - JOUR

T1 - Persistent behavioral and neurochemical sensitization to an acute injection of methamphetamine following unpredictable stress

AU - Matuszewich, Leslie

AU - Carter, Samantha

AU - Anderson, Eden M.

AU - Friedman, Ross D.

AU - McFadden, Lisa M.

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Prior research in humans and animals suggest that exposure to chronic stress alters the response to drugs of abuse, increasing vulnerability to drug addiction. Chronic unpredictable stress (CUS) has been shown to augment the increase of dopamine in the striatum when challenged with high doses of methamphetamine immediately following stress exposure, however it is not known whether this neurochemical stress-sensitization continues after the cessation of the stressors or if behavioral sensitization is also present. Therefore, the current study examined the immediate and delayed effects of CUS on methamphetamine-induced behaviors and striatal dopamine levels. Male rats were exposed to 10 days of CUS and then tested in either an open field box to assess locomotion or underwent in vivo microdialysis to measure striatal dopamine levels immediately following CUS or after a 1-2 week delay. All rats exposed to CUS showed a potentiated locomotor response immediately following an acute injection of 7.5. mg/kg methamphetamine compared to non-stressed control rats. Both groups of CUS rats also showed augmented dopamine release and rectal temperatures following methamphetamine with prolonged increases in the CUS rats tested after a delay. These results suggest that CUS increases the sensitivity of a rat to a single injection of methamphetamine and that the increased sensitivity persists for up to 2 weeks following the last stressor.

AB - Prior research in humans and animals suggest that exposure to chronic stress alters the response to drugs of abuse, increasing vulnerability to drug addiction. Chronic unpredictable stress (CUS) has been shown to augment the increase of dopamine in the striatum when challenged with high doses of methamphetamine immediately following stress exposure, however it is not known whether this neurochemical stress-sensitization continues after the cessation of the stressors or if behavioral sensitization is also present. Therefore, the current study examined the immediate and delayed effects of CUS on methamphetamine-induced behaviors and striatal dopamine levels. Male rats were exposed to 10 days of CUS and then tested in either an open field box to assess locomotion or underwent in vivo microdialysis to measure striatal dopamine levels immediately following CUS or after a 1-2 week delay. All rats exposed to CUS showed a potentiated locomotor response immediately following an acute injection of 7.5. mg/kg methamphetamine compared to non-stressed control rats. Both groups of CUS rats also showed augmented dopamine release and rectal temperatures following methamphetamine with prolonged increases in the CUS rats tested after a delay. These results suggest that CUS increases the sensitivity of a rat to a single injection of methamphetamine and that the increased sensitivity persists for up to 2 weeks following the last stressor.

KW - Dopamine

KW - Hyperthermia

KW - Locomotion

KW - Methamphetamine

KW - Microdialysis

KW - Sensitization

KW - Unpredictable stress

UR - http://www.scopus.com/inward/record.url?scp=84904878902&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904878902&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2014.07.013

DO - 10.1016/j.bbr.2014.07.013

M3 - Article

C2 - 25036423

AN - SCOPUS:84904878902

VL - 272

SP - 308

EP - 313

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

ER -