Peroxides as oxidant antimalarials

J. L. Vennerstrom, N. Acton, A. J. Lin, D. L. Klayman

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Abstract

To further explore the antimalarial activity of peroxides (e.g. artmisinin 1), twenty-three peroxides (all the compounds shown in Figures 3 and 4) of diverse chemical structure and acceptable stability were selected and tested for antimalarial activity in vitro against Plasmodium falciparum, and in mice against P. berghei. Included were hydroperoxides, dialkyl peroxides, acyl and diacylperoxides, peroxyketals, peroxycarbonates, and endoperoxides. None was active in vivo, although several were reasonably potent in vitro.

Original languageEnglish (US)
Pages (from-to)45-54
Number of pages10
JournalDrug Design and Delivery
Volume4
Issue number1
Publication statusPublished - Dec 1 1988

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ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

Cite this

Vennerstrom, J. L., Acton, N., Lin, A. J., & Klayman, D. L. (1988). Peroxides as oxidant antimalarials. Drug Design and Delivery, 4(1), 45-54.