Abstract

Although PTCL in children, as in adults, has a spectrum of clinical, morphologic, cytogenetic and immunologic features, there are several significant differences in these features between children and adults. Our data show that CD30 expression is much more common in pediatric PTCL than is reported in adult PTCL. Furthermore, the majority of children with CD30-positive PTCL do not have tumors with anaplastic large cell histology. Our data also suggest that the t(2;5) is not a specific marker of anaplastic large cell lymphoma in childhood. The likelihood of cure for children with PTCL is unclear, predominately because of the lack of large numbers of pediatric patients with this less common entity. As with other NHL, we expect that treatment with conventional dose chemotherapy following relapse will be unsuccessful in most cases. Although the data are preliminary, it appears that high dose chemo-radiotherapy followed by hematopoietic stem cell transplantation is an effective therapy in these patients. We have been particularly successful with a regimen based on thioTEPA, VP-16 and total body irradiation, but other regimens may also be efficacious. Further studies of this interesting group of tumors are clearly needed.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalLeukemia and Lymphoma
Volume14
Issue number1-2
DOIs
StatePublished - Jan 1 1994

Fingerprint

Bone Marrow Transplantation
Lymphoma
Pediatrics
Thiotepa
Anaplastic Large-Cell Lymphoma
Whole-Body Irradiation
Hematopoietic Stem Cell Transplantation
Etoposide
Cytogenetics
Neoplasms
Histology
Radiotherapy
Recurrence
Drug Therapy
Therapeutics

Keywords

  • Adolescents bone marrow transplantation
  • Childhood lymphoma
  • Ki-1 lymphoma
  • Peripheral T-cell lymphoma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Peripheral t-cell lymphoma in children and adolescents : Role of bone marrow transplantation. / Gordon, Bruce Geoffrey; Weisenburger, Dennis D.; Sanger, Warren G.; Armitage, James Olen; Coccia, Peter F.

In: Leukemia and Lymphoma, Vol. 14, No. 1-2, 01.01.1994, p. 1-10.

Research output: Contribution to journalArticle

Gordon, Bruce Geoffrey ; Weisenburger, Dennis D. ; Sanger, Warren G. ; Armitage, James Olen ; Coccia, Peter F. / Peripheral t-cell lymphoma in children and adolescents : Role of bone marrow transplantation. In: Leukemia and Lymphoma. 1994 ; Vol. 14, No. 1-2. pp. 1-10.
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