Peripheral nerve induces macrophage neurotrophic activities: Regulation of neuronal process outgrowth, intracellular signaling and synaptic function

Annemarie Shibata, Marina Zelivyanskaya, Jenae Limoges, Kim A Carlson, Santhi Gorantla, Chad E Branecki, Shrinivas Bishu, Huangui Xiong, Howard Eliot Gendelman

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Rat cortical neurons cultured in conditioned media from human monocyte-derived macrophages (MDM) show increased neuronal protein synthesis, neurite outgrowth, mitogen-activating protein kinase activity, and synaptic function. Neurotrophic properties of human MDM-conditioned media are significantly enhanced by human peripheral nerve and to a more limited extent by CD40 ligand pre-stimulation. Such positive effects of MDM secretions on neuronal function parallel the secretion of brain-derived neurotrophic factor (BDNF). MDM activation cues may serve to balance toxic activities produced during neurodegenerative diseases and thus, under certain circumstances, mitigate neuronal degeneration.

Original languageEnglish (US)
Pages (from-to)112-129
Number of pages18
JournalJournal of Neuroimmunology
Volume142
Issue number1-2
DOIs
StatePublished - Sep 1 2003

Fingerprint

Peripheral Nerves
Macrophages
Conditioned Culture Medium
CD40 Ligand
Macrophage Activation
Poisons
Brain-Derived Neurotrophic Factor
Mitogens
Neurodegenerative Diseases
Protein Kinases
Cues
Neurons
Neuronal Outgrowth
Proteins

Keywords

  • Monocyte-derived macrophages
  • Neurotrophins
  • Signal transduction

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Peripheral nerve induces macrophage neurotrophic activities : Regulation of neuronal process outgrowth, intracellular signaling and synaptic function. / Shibata, Annemarie; Zelivyanskaya, Marina; Limoges, Jenae; Carlson, Kim A; Gorantla, Santhi; Branecki, Chad E; Bishu, Shrinivas; Xiong, Huangui; Gendelman, Howard Eliot.

In: Journal of Neuroimmunology, Vol. 142, No. 1-2, 01.09.2003, p. 112-129.

Research output: Contribution to journalArticle

@article{b81d1637d71b41e79e87af701aaf77eb,
title = "Peripheral nerve induces macrophage neurotrophic activities: Regulation of neuronal process outgrowth, intracellular signaling and synaptic function",
abstract = "Rat cortical neurons cultured in conditioned media from human monocyte-derived macrophages (MDM) show increased neuronal protein synthesis, neurite outgrowth, mitogen-activating protein kinase activity, and synaptic function. Neurotrophic properties of human MDM-conditioned media are significantly enhanced by human peripheral nerve and to a more limited extent by CD40 ligand pre-stimulation. Such positive effects of MDM secretions on neuronal function parallel the secretion of brain-derived neurotrophic factor (BDNF). MDM activation cues may serve to balance toxic activities produced during neurodegenerative diseases and thus, under certain circumstances, mitigate neuronal degeneration.",
keywords = "Monocyte-derived macrophages, Neurotrophins, Signal transduction",
author = "Annemarie Shibata and Marina Zelivyanskaya and Jenae Limoges and Carlson, {Kim A} and Santhi Gorantla and Branecki, {Chad E} and Shrinivas Bishu and Huangui Xiong and Gendelman, {Howard Eliot}",
year = "2003",
month = "9",
day = "1",
doi = "10.1016/S0165-5728(03)00253-4",
language = "English (US)",
volume = "142",
pages = "112--129",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Peripheral nerve induces macrophage neurotrophic activities

T2 - Regulation of neuronal process outgrowth, intracellular signaling and synaptic function

AU - Shibata, Annemarie

AU - Zelivyanskaya, Marina

AU - Limoges, Jenae

AU - Carlson, Kim A

AU - Gorantla, Santhi

AU - Branecki, Chad E

AU - Bishu, Shrinivas

AU - Xiong, Huangui

AU - Gendelman, Howard Eliot

PY - 2003/9/1

Y1 - 2003/9/1

N2 - Rat cortical neurons cultured in conditioned media from human monocyte-derived macrophages (MDM) show increased neuronal protein synthesis, neurite outgrowth, mitogen-activating protein kinase activity, and synaptic function. Neurotrophic properties of human MDM-conditioned media are significantly enhanced by human peripheral nerve and to a more limited extent by CD40 ligand pre-stimulation. Such positive effects of MDM secretions on neuronal function parallel the secretion of brain-derived neurotrophic factor (BDNF). MDM activation cues may serve to balance toxic activities produced during neurodegenerative diseases and thus, under certain circumstances, mitigate neuronal degeneration.

AB - Rat cortical neurons cultured in conditioned media from human monocyte-derived macrophages (MDM) show increased neuronal protein synthesis, neurite outgrowth, mitogen-activating protein kinase activity, and synaptic function. Neurotrophic properties of human MDM-conditioned media are significantly enhanced by human peripheral nerve and to a more limited extent by CD40 ligand pre-stimulation. Such positive effects of MDM secretions on neuronal function parallel the secretion of brain-derived neurotrophic factor (BDNF). MDM activation cues may serve to balance toxic activities produced during neurodegenerative diseases and thus, under certain circumstances, mitigate neuronal degeneration.

KW - Monocyte-derived macrophages

KW - Neurotrophins

KW - Signal transduction

UR - http://www.scopus.com/inward/record.url?scp=0642370977&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0642370977&partnerID=8YFLogxK

U2 - 10.1016/S0165-5728(03)00253-4

DO - 10.1016/S0165-5728(03)00253-4

M3 - Article

C2 - 14512170

AN - SCOPUS:0642370977

VL - 142

SP - 112

EP - 129

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1-2

ER -