Peripheral insulin-like growth factor-I produces antidepressant-like behavior and contributes to the effect of exercise

Catharine H. Duman, Lee Schlesinger, Rosemarie Terwilliger, David S. Russell, Samuel S. Newton, Ronald S. Duman

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Growth factors in the brain are important to depression and it's treatment and we assessed the ability of peripherally administered insulin-like growth factor-I (IGF-I) to influence behavior related to depression. We found that mice that received chronic IGF-I treatment showed antidepressant-like behavior in forced-swim and novelty-induced hypophagia (NIH) tests and increased sucrose consumption after chronic mild unpredictable stress exposure. Additionally, peripheral anti-IGF-I administration blocked exercise-induced antidepressant effects in the forced-swim test (FST). These results support the functional relevance of neurotrophic mechanisms to depression and extend this idea to include neurotrophic factors in the periphery.

Original languageEnglish (US)
Pages (from-to)366-371
Number of pages6
JournalBehavioural Brain Research
Volume198
Issue number2
DOIs
StatePublished - Mar 17 2009

Fingerprint

Insulin-Like Growth Factor I
Antidepressive Agents
Depression
Aptitude
Nerve Growth Factors
Sucrose
Intercellular Signaling Peptides and Proteins
Brain

Keywords

  • Antidepressant
  • Behavior
  • Exercise
  • Forced-swim test
  • IGF-I
  • Mouse
  • Novelty-induced hypophagia

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Peripheral insulin-like growth factor-I produces antidepressant-like behavior and contributes to the effect of exercise. / Duman, Catharine H.; Schlesinger, Lee; Terwilliger, Rosemarie; Russell, David S.; Newton, Samuel S.; Duman, Ronald S.

In: Behavioural Brain Research, Vol. 198, No. 2, 17.03.2009, p. 366-371.

Research output: Contribution to journalArticle

Duman, Catharine H. ; Schlesinger, Lee ; Terwilliger, Rosemarie ; Russell, David S. ; Newton, Samuel S. ; Duman, Ronald S. / Peripheral insulin-like growth factor-I produces antidepressant-like behavior and contributes to the effect of exercise. In: Behavioural Brain Research. 2009 ; Vol. 198, No. 2. pp. 366-371.
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