Peripheral insulin-like growth factor-I produces antidepressant-like behavior and contributes to the effect of exercise

Catharine H. Duman, Lee Schlesinger, Rosemarie Terwilliger, David S. Russell, Samuel S. Newton, Ronald S. Duman

Research output: Contribution to journalArticle

92 Scopus citations


Growth factors in the brain are important to depression and it's treatment and we assessed the ability of peripherally administered insulin-like growth factor-I (IGF-I) to influence behavior related to depression. We found that mice that received chronic IGF-I treatment showed antidepressant-like behavior in forced-swim and novelty-induced hypophagia (NIH) tests and increased sucrose consumption after chronic mild unpredictable stress exposure. Additionally, peripheral anti-IGF-I administration blocked exercise-induced antidepressant effects in the forced-swim test (FST). These results support the functional relevance of neurotrophic mechanisms to depression and extend this idea to include neurotrophic factors in the periphery.

Original languageEnglish (US)
Pages (from-to)366-371
Number of pages6
JournalBehavioural Brain Research
Issue number2
Publication statusPublished - Mar 17 2009



  • Antidepressant
  • Behavior
  • Exercise
  • Forced-swim test
  • IGF-I
  • Mouse
  • Novelty-induced hypophagia

ASJC Scopus subject areas

  • Behavioral Neuroscience

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