Perioperative changes in prouroguanylin hormone response in severely obese subjects after bariatric surgery

Alfonso Torquati, Prapimporn Chattranukulchai Shantavasinkul, Philip Omotosho, Leonor Corsino, Anna Spagnoli

Research output: Contribution to journalArticle

Abstract

Background: Prouroguanylin is a gut hormone converted into uroguanylin in the hypothalamus. Uroguanylin induces satiety through guanylyl-cyclase-2C receptor signaling. However, little is known about the role of this hormone in regulating human food intake. Methods: In prospective-cohort study, prouroguanylin profile changes were determined during meal stimulation in obese patients 2 weeks before and 2 weeks after Roux-en-Y gastric bypass surgery. We also investigated whether these changes play a role in the anorexigenic effect of Roux-en-Y gastric bypass. Results: The study enrolled 8 healthy lean volunteers and 10 obese patients with type 2 diabetes. Prouroguanylin levels were postprandially decreased at 30 minutes (P =.04) and 60 minutes (P =.008) in obese patients before surgery, and they were increased at 60 minutes (P =.003), 90 minutes (P =.008), and 120 minutes (P =.009) after surgery. We observed a significant difference (P =.001) in fasting prouroguanylin levels before (8.82 ± 1.2 ng/mL) and after (6.05 ± 1.2 ng/mL) Roux-en-Y gastric bypass. Hunger ratings in the fasted state did not change after Roux-en-Y gastric bypass. Instead, subjects demonstrated significantly (P =.01) lower hunger visual analog scale scores than before Roux-en-Y gastric bypass. No correlations between circulating prouroguanylin levels and hunger perception were found before or after Roux-en-Y gastric bypass. Conclusion: Prouroguanylin levels decrease after meal stimulation in obese patients, and they increase after Roux-en-Y gastric bypass, but no correlations exist with hunger visual analog scale scores.

Original languageEnglish (US)
Pages (from-to)456-459
Number of pages4
JournalSurgery (United States)
Volume166
Issue number4
DOIs
StatePublished - Oct 2019

Fingerprint

Bariatric Surgery
Gastric Bypass
Hormones
Hunger
Visual Analog Scale
Meals
Guanylate Cyclase-Coupled Receptors
prouroguanylin
Type 2 Diabetes Mellitus
Hypothalamus
Fasting
Healthy Volunteers
Cohort Studies
Eating
Prospective Studies

ASJC Scopus subject areas

  • Surgery

Cite this

Perioperative changes in prouroguanylin hormone response in severely obese subjects after bariatric surgery. / Torquati, Alfonso; Shantavasinkul, Prapimporn Chattranukulchai; Omotosho, Philip; Corsino, Leonor; Spagnoli, Anna.

In: Surgery (United States), Vol. 166, No. 4, 10.2019, p. 456-459.

Research output: Contribution to journalArticle

Torquati, Alfonso ; Shantavasinkul, Prapimporn Chattranukulchai ; Omotosho, Philip ; Corsino, Leonor ; Spagnoli, Anna. / Perioperative changes in prouroguanylin hormone response in severely obese subjects after bariatric surgery. In: Surgery (United States). 2019 ; Vol. 166, No. 4. pp. 456-459.
@article{ee71034b30434b61ac50682f8fb04151,
title = "Perioperative changes in prouroguanylin hormone response in severely obese subjects after bariatric surgery",
abstract = "Background: Prouroguanylin is a gut hormone converted into uroguanylin in the hypothalamus. Uroguanylin induces satiety through guanylyl-cyclase-2C receptor signaling. However, little is known about the role of this hormone in regulating human food intake. Methods: In prospective-cohort study, prouroguanylin profile changes were determined during meal stimulation in obese patients 2 weeks before and 2 weeks after Roux-en-Y gastric bypass surgery. We also investigated whether these changes play a role in the anorexigenic effect of Roux-en-Y gastric bypass. Results: The study enrolled 8 healthy lean volunteers and 10 obese patients with type 2 diabetes. Prouroguanylin levels were postprandially decreased at 30 minutes (P =.04) and 60 minutes (P =.008) in obese patients before surgery, and they were increased at 60 minutes (P =.003), 90 minutes (P =.008), and 120 minutes (P =.009) after surgery. We observed a significant difference (P =.001) in fasting prouroguanylin levels before (8.82 ± 1.2 ng/mL) and after (6.05 ± 1.2 ng/mL) Roux-en-Y gastric bypass. Hunger ratings in the fasted state did not change after Roux-en-Y gastric bypass. Instead, subjects demonstrated significantly (P =.01) lower hunger visual analog scale scores than before Roux-en-Y gastric bypass. No correlations between circulating prouroguanylin levels and hunger perception were found before or after Roux-en-Y gastric bypass. Conclusion: Prouroguanylin levels decrease after meal stimulation in obese patients, and they increase after Roux-en-Y gastric bypass, but no correlations exist with hunger visual analog scale scores.",
author = "Alfonso Torquati and Shantavasinkul, {Prapimporn Chattranukulchai} and Philip Omotosho and Leonor Corsino and Anna Spagnoli",
year = "2019",
month = "10",
doi = "10.1016/j.surg.2019.06.037",
language = "English (US)",
volume = "166",
pages = "456--459",
journal = "Surgery (United States)",
issn = "0039-6060",
publisher = "Mosby Inc.",
number = "4",

}

TY - JOUR

T1 - Perioperative changes in prouroguanylin hormone response in severely obese subjects after bariatric surgery

AU - Torquati, Alfonso

AU - Shantavasinkul, Prapimporn Chattranukulchai

AU - Omotosho, Philip

AU - Corsino, Leonor

AU - Spagnoli, Anna

PY - 2019/10

Y1 - 2019/10

N2 - Background: Prouroguanylin is a gut hormone converted into uroguanylin in the hypothalamus. Uroguanylin induces satiety through guanylyl-cyclase-2C receptor signaling. However, little is known about the role of this hormone in regulating human food intake. Methods: In prospective-cohort study, prouroguanylin profile changes were determined during meal stimulation in obese patients 2 weeks before and 2 weeks after Roux-en-Y gastric bypass surgery. We also investigated whether these changes play a role in the anorexigenic effect of Roux-en-Y gastric bypass. Results: The study enrolled 8 healthy lean volunteers and 10 obese patients with type 2 diabetes. Prouroguanylin levels were postprandially decreased at 30 minutes (P =.04) and 60 minutes (P =.008) in obese patients before surgery, and they were increased at 60 minutes (P =.003), 90 minutes (P =.008), and 120 minutes (P =.009) after surgery. We observed a significant difference (P =.001) in fasting prouroguanylin levels before (8.82 ± 1.2 ng/mL) and after (6.05 ± 1.2 ng/mL) Roux-en-Y gastric bypass. Hunger ratings in the fasted state did not change after Roux-en-Y gastric bypass. Instead, subjects demonstrated significantly (P =.01) lower hunger visual analog scale scores than before Roux-en-Y gastric bypass. No correlations between circulating prouroguanylin levels and hunger perception were found before or after Roux-en-Y gastric bypass. Conclusion: Prouroguanylin levels decrease after meal stimulation in obese patients, and they increase after Roux-en-Y gastric bypass, but no correlations exist with hunger visual analog scale scores.

AB - Background: Prouroguanylin is a gut hormone converted into uroguanylin in the hypothalamus. Uroguanylin induces satiety through guanylyl-cyclase-2C receptor signaling. However, little is known about the role of this hormone in regulating human food intake. Methods: In prospective-cohort study, prouroguanylin profile changes were determined during meal stimulation in obese patients 2 weeks before and 2 weeks after Roux-en-Y gastric bypass surgery. We also investigated whether these changes play a role in the anorexigenic effect of Roux-en-Y gastric bypass. Results: The study enrolled 8 healthy lean volunteers and 10 obese patients with type 2 diabetes. Prouroguanylin levels were postprandially decreased at 30 minutes (P =.04) and 60 minutes (P =.008) in obese patients before surgery, and they were increased at 60 minutes (P =.003), 90 minutes (P =.008), and 120 minutes (P =.009) after surgery. We observed a significant difference (P =.001) in fasting prouroguanylin levels before (8.82 ± 1.2 ng/mL) and after (6.05 ± 1.2 ng/mL) Roux-en-Y gastric bypass. Hunger ratings in the fasted state did not change after Roux-en-Y gastric bypass. Instead, subjects demonstrated significantly (P =.01) lower hunger visual analog scale scores than before Roux-en-Y gastric bypass. No correlations between circulating prouroguanylin levels and hunger perception were found before or after Roux-en-Y gastric bypass. Conclusion: Prouroguanylin levels decrease after meal stimulation in obese patients, and they increase after Roux-en-Y gastric bypass, but no correlations exist with hunger visual analog scale scores.

UR - http://www.scopus.com/inward/record.url?scp=85071381924&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071381924&partnerID=8YFLogxK

U2 - 10.1016/j.surg.2019.06.037

DO - 10.1016/j.surg.2019.06.037

M3 - Article

C2 - 31472974

AN - SCOPUS:85071381924

VL - 166

SP - 456

EP - 459

JO - Surgery (United States)

JF - Surgery (United States)

SN - 0039-6060

IS - 4

ER -