Periocular lymphoproliferative diseases: Natural history, prognostic factors, and treatment

Beth A. Erickson, Gerald J. Harris, Charles Arthur Enke, Kevin J. Murray, Bruce M. Massaro, Gerald A. Hanson, Richard M. Hansen, Tom Anderson, J. Frank Wilson

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A study was undertaken to assess the natural history of periocular lymphoproliferative diseases, identify key prognostic factors, and clarify the role of orbital irradiation. Thirty-four patients with periocular lymphoproliferative disease were treated with orbital irradiation between 1975 and 1990. Eight patients had atypical lymphoid infiltrate, and 26 had malignant lymphoma. Forty-three eyes were irradiated with en-face electrons or 6-MV photons. Five-year disease-free survival for all stages was 65%; it was not significantly affected by bilaterality or site. Stage, distinction between atypical lymphoid infiltrate and malignant lymphoma, and working formulation grade were important prognostic indicators. A complete response during irradiation was achieved in 24 of 43 (56%) eyes at a median dose of 2,400 cGy, and a partial response was achieved in 19 (44%), with resolution at a median of 2.8 months. Patients with periocular reactive lymphoid hyperplasia or atypical lymphoid infiltrate may have or are at significant risk of developing lymphoma and dissemination. Local treatment remains important; orbital irradiation achieves prompt local control with acceptable morbidity.

Original languageEnglish (US)
Pages (from-to)63-70
Number of pages8
JournalRadiology
Volume185
Issue number1
DOIs
StatePublished - Jan 1 1992

Fingerprint

Natural History
Lymphoma
Pseudolymphoma
Photons
Disease-Free Survival
Therapeutics
Electrons
Morbidity

Keywords

  • Eye, neoplasms
  • Eye, therapeutic radiology
  • Lymphoma, therapy
  • Orbit, neoplasms
  • Orbit, therapeutic radiology

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Erickson, B. A., Harris, G. J., Enke, C. A., Murray, K. J., Massaro, B. M., Hanson, G. A., ... Wilson, J. F. (1992). Periocular lymphoproliferative diseases: Natural history, prognostic factors, and treatment. Radiology, 185(1), 63-70. https://doi.org/10.1148/radiology.185.1.1523336

Periocular lymphoproliferative diseases : Natural history, prognostic factors, and treatment. / Erickson, Beth A.; Harris, Gerald J.; Enke, Charles Arthur; Murray, Kevin J.; Massaro, Bruce M.; Hanson, Gerald A.; Hansen, Richard M.; Anderson, Tom; Wilson, J. Frank.

In: Radiology, Vol. 185, No. 1, 01.01.1992, p. 63-70.

Research output: Contribution to journalArticle

Erickson, BA, Harris, GJ, Enke, CA, Murray, KJ, Massaro, BM, Hanson, GA, Hansen, RM, Anderson, T & Wilson, JF 1992, 'Periocular lymphoproliferative diseases: Natural history, prognostic factors, and treatment', Radiology, vol. 185, no. 1, pp. 63-70. https://doi.org/10.1148/radiology.185.1.1523336
Erickson, Beth A. ; Harris, Gerald J. ; Enke, Charles Arthur ; Murray, Kevin J. ; Massaro, Bruce M. ; Hanson, Gerald A. ; Hansen, Richard M. ; Anderson, Tom ; Wilson, J. Frank. / Periocular lymphoproliferative diseases : Natural history, prognostic factors, and treatment. In: Radiology. 1992 ; Vol. 185, No. 1. pp. 63-70.
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