Pericytoma with t(7;12) and ACTB-GLI1 fusion arising in bone

Julia A. Bridge, Kyle Sanders, Dali Huang, Marilu Nelson, James R. Neff, David Muirhead, Craig Walker, Thomas A. Seemayer, Janos Sumegi

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Abstract

Cytogenetic analysis of a primary bone neoplasm with pericytic features in a 67-year-old man revealed a t(7;12)(p22;q13) among other karyotypic abnormalities. Subsequent molecular studies confirmed the presence of an associated ACTB-GLI1 fusion transcript. An identical 7;12 translocation is known to characterize a discrete group of soft tissue tumors belonging to the myopericytic category termed pericytoma with t(7;12). To the best of our knowledge, this is the first case of pericytoma with t(7;12) arising in bone. Cytogenetic and molecular analyses were useful, if not essential, in classifying this rare diagnostic entity.

Original languageEnglish (US)
Pages (from-to)1524-1529
Number of pages6
JournalHuman Pathology
Volume43
Issue number9
DOIs
StatePublished - Sep 1 2012

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Keywords

  • ACTB
  • GLI1
  • Perictyoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Bridge, J. A., Sanders, K., Huang, D., Nelson, M., Neff, J. R., Muirhead, D., Walker, C., Seemayer, T. A., & Sumegi, J. (2012). Pericytoma with t(7;12) and ACTB-GLI1 fusion arising in bone. Human Pathology, 43(9), 1524-1529. https://doi.org/10.1016/j.humpath.2012.01.019