Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions

Oliver Karam, Pierre Demaret, Alain Duhamel, Alison Shefler, Philip C. Spinella, Simon J. Stanworth, Marisa Tucci, Stéphane Leteurtre, the PlasmaTV investigators for the PlasmaTV investigators, Warwick Butt, Carmel Delzoppo, Kym Bain, Simon Erickson, Nathan Smalley, Tavey Dorofaeff, Debbie Long, Greg Wiseman, Stéphan Clénent de Cléty, Caroline Berghe, Annick de JaegerPierre Demaret, Marc Trippaerts, Ariane Willems, Shancy Rooze, Jozef De Dooy, Elaine Gilfoyle, Lynette Wohlgemuth, Marisa Tucci, Mariana Dumitrascu, Davinia Withington, Julia Hickey, Karen Choong, Lois Sanders, Gavin Morrison, Janice Tijssen, David Wensley, Gordon Krahn, Marc Andre Dugas, Louise Gosselin, Miriam Santschi, Bettina Von Dessauer, Nadia Ordenes, Arash Afshari, Lasse Hoegh Andersen, Jens Christian Nilsson, Mathias Johansen, Anne Mette Baek Jensen, Santiago Campos Mino, Michelle Grunauer, Nicolas Joram, Nicolas Roullet-Renoleau, Etienne Javouhey, Fleur Cour-Andlauer, Aurélie Portefaix, Olivier Brissaud, Julie Guichoux, Valérie Payen, Pierre Louis Léger, Mickael Afanetti, Guillaume Mortamet, Matthieu Maria, Audrey Breining, Pierre Tissieres, Aimée Dorkenoo, Anna Deho, Harry Steinherr, Filippia Nikolaou, Anna Camporesi, Federica Mario, Tatsuya Kawasaki, Shinya Miura, John Beca, Miriam Rea, Claire Sherring, Tracey Bushell, Gunnar Bentsen, Alexandra Dinis, Gabriela Pereira, Marisa Vieira, Marta Moniz, Saleh Alshehri, Manal Alasnag, Maria Pisarcikova, Iolanda Jordan, Joan Balcells, Antonio Perez-Ferrer, Jesús de Vicente Sánchez, Marta Vazquez Moyano, Antonio Morales Martinez, Jesus Lopez-Herce, Maria Jose Solana, Jose Carlos Flores González, Maria Teresa Alonso, Manuel Nieto Faza, Marie Hélène Perez, Vivianne Amiet, Carsten Doell, Alice Bordessoule, Suzan Cochius-den Otter, Berber Kapitein, Martin Kneyber, Joe Brierley, Vanessa Rea, Stephen McKeever, Andrea Kelleher, Barney Scholefield, Anke Top, Nicola Kelly, Satnam Virdee, Peter Davis, Susan George, Kay C. Hawkins, Katie McCall, Victoria Brown, Kim Sykes, Richard Levin, Isobel MacLeod, Marie Horan, Petr Jirasek, David Inwald, Amina Abdulla, Sophie Raghunanan, Bob Taylor, Alison Shefler, Hannah Sparkes, Sheila Hanson, Katherine Woods, David Triscari, Kathy Murkowski, Caroline Ozment, Marie Steiner, Dan Nerheim, Amanda Galster, Renee Higgerson, Lee Ann Christie, Philip C. Spinella, Daniel Martin, Liz Rourke, Jennifer Muszynski, Lisa Steele, Samuel Ajizian, Michael C. McCrory, Kevin O’Brien, Christopher Babbitt, Erin Felkel, Glenn Levine, Edward J. Truemper, Machelle Zink, Marianne Nellis, Neal J. Thomas, Debbie Spear, Barry Markovitz, Jeff Terry, Rica Morzov, Vicki Montgomery, Andrew Michael, Melissa Thomas, Marcy Singleton, Dean Jarvis, Sholeen Nett, Douglas Willson, Michelle Hoot, Melania Bembea, Alvin Yiu, David McKinley, Elizabeth Scarlett, Jennifer Sankey, Minal Parikh, E. Vincent, S. Faustino, Kelly Michelson, Jay Rilinger, Laura Campbell, Shira Gertz, Jill M. Cholette, Asumthia Jeyapalan, Margaret Parker, Scot Bateman, Amanda Johnson

Research output: Contribution to journalArticle

Abstract

Background: Organ dysfunction scores, based on physiological parameters, have been created to describe organ failure. In a general pediatric intensive care unit (PICU) population, the PEdiatric Logistic Organ Dysfunction-2 score (PELOD-2) score had both a good discrimination and calibration, allowing to describe the clinical outcome of critically ill children throughout their stay. This score is increasingly used in clinical trials in specific subpopulation. Our objective was to assess the performance of the PELOD-2 score in a subpopulation of critically ill children requiring plasma transfusions. Methods: This was an ancillary study of a prospective observational study on plasma transfusions over a 6-week period, in 101 PICUs in 21 countries. All critically ill children who received at least one plasma transfusion during the observation period were included. PELOD-2 scores were measured on days 1, 2, 5, 8, and 12 after plasma transfusion. Performance of the score was assessed by the determination of the discrimination (area under the ROC curve: AUC) and the calibration (Hosmer–Lemeshow test). Results: Four hundred and forty-three patients were enrolled in the study (median age and weight: 1 year and 9.1 kg, respectively). Observed mortality rate was 26.9 % (119/443). For PELOD-2 on day 1, the AUC was 0.76 (95 % CI 0.71–0.81) and the Hosmer–Lemeshow test was p = 0.76. The serial evaluation of the changes in the daily PELOD-2 scores from day 1 demonstrated a significant association with death, adjusted for the PELOD-2 score on day 1. Conclusions: In a subpopulation of critically ill children requiring plasma transfusion, the PELOD-2 score has a lower but acceptable discrimination than in an entire population. This score should therefore be used cautiously in this specific subpopulation.

Original languageEnglish (US)
Article number98
JournalAnnals of Intensive Care
Volume6
Issue number1
DOIs
StatePublished - Dec 1 2016

Fingerprint

Organ Dysfunction Scores
Critical Illness
Pediatrics
Area Under Curve
Calibration
Pediatric Intensive Care Units
ROC Curve
Population
Observational Studies
Observation
Clinical Trials
Prospective Studies
Weights and Measures
Mortality

Keywords

  • Children
  • Critical care
  • Multiple organ failure
  • Outcome
  • Plasma transfusion
  • Score

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Karam, O., Demaret, P., Duhamel, A., Shefler, A., Spinella, P. C., Stanworth, S. J., ... Johnson, A. (2016). Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions. Annals of Intensive Care, 6(1), [98]. https://doi.org/10.1186/s13613-016-0197-6

Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions. / Karam, Oliver; Demaret, Pierre; Duhamel, Alain; Shefler, Alison; Spinella, Philip C.; Stanworth, Simon J.; Tucci, Marisa; Leteurtre, Stéphane; for the PlasmaTV investigators, the PlasmaTV investigators; Butt, Warwick; Delzoppo, Carmel; Bain, Kym; Erickson, Simon; Smalley, Nathan; Dorofaeff, Tavey; Long, Debbie; Wiseman, Greg; Clénent de Cléty, Stéphan; Berghe, Caroline; de Jaeger, Annick; Demaret, Pierre; Trippaerts, Marc; Willems, Ariane; Rooze, Shancy; De Dooy, Jozef; Gilfoyle, Elaine; Wohlgemuth, Lynette; Tucci, Marisa; Dumitrascu, Mariana; Withington, Davinia; Hickey, Julia; Choong, Karen; Sanders, Lois; Morrison, Gavin; Tijssen, Janice; Wensley, David; Krahn, Gordon; Dugas, Marc Andre; Gosselin, Louise; Santschi, Miriam; Von Dessauer, Bettina; Ordenes, Nadia; Afshari, Arash; Andersen, Lasse Hoegh; Nilsson, Jens Christian; Johansen, Mathias; Baek Jensen, Anne Mette; Campos Mino, Santiago; Grunauer, Michelle; Joram, Nicolas; Roullet-Renoleau, Nicolas; Javouhey, Etienne; Cour-Andlauer, Fleur; Portefaix, Aurélie; Brissaud, Olivier; Guichoux, Julie; Payen, Valérie; Léger, Pierre Louis; Afanetti, Mickael; Mortamet, Guillaume; Maria, Matthieu; Breining, Audrey; Tissieres, Pierre; Dorkenoo, Aimée; Deho, Anna; Steinherr, Harry; Nikolaou, Filippia; Camporesi, Anna; Mario, Federica; Kawasaki, Tatsuya; Miura, Shinya; Beca, John; Rea, Miriam; Sherring, Claire; Bushell, Tracey; Bentsen, Gunnar; Dinis, Alexandra; Pereira, Gabriela; Vieira, Marisa; Moniz, Marta; Alshehri, Saleh; Alasnag, Manal; Pisarcikova, Maria; Jordan, Iolanda; Balcells, Joan; Perez-Ferrer, Antonio; de Vicente Sánchez, Jesús; Vazquez Moyano, Marta; Morales Martinez, Antonio; Lopez-Herce, Jesus; Solana, Maria Jose; Flores González, Jose Carlos; Alonso, Maria Teresa; Nieto Faza, Manuel; Perez, Marie Hélène; Amiet, Vivianne; Doell, Carsten; Bordessoule, Alice; Cochius-den Otter, Suzan; Kapitein, Berber; Kneyber, Martin; Brierley, Joe; Rea, Vanessa; McKeever, Stephen; Kelleher, Andrea; Scholefield, Barney; Top, Anke; Kelly, Nicola; Virdee, Satnam; Davis, Peter; George, Susan; Hawkins, Kay C.; McCall, Katie; Brown, Victoria; Sykes, Kim; Levin, Richard; MacLeod, Isobel; Horan, Marie; Jirasek, Petr; Inwald, David; Abdulla, Amina; Raghunanan, Sophie; Taylor, Bob; Shefler, Alison; Sparkes, Hannah; Hanson, Sheila; Woods, Katherine; Triscari, David; Murkowski, Kathy; Ozment, Caroline; Steiner, Marie; Nerheim, Dan; Galster, Amanda; Higgerson, Renee; Christie, Lee Ann; Spinella, Philip C.; Martin, Daniel; Rourke, Liz; Muszynski, Jennifer; Steele, Lisa; Ajizian, Samuel; McCrory, Michael C.; O’Brien, Kevin; Babbitt, Christopher; Felkel, Erin; Levine, Glenn; Truemper, Edward J.; Zink, Machelle; Nellis, Marianne; Thomas, Neal J.; Spear, Debbie; Markovitz, Barry; Terry, Jeff; Morzov, Rica; Montgomery, Vicki; Michael, Andrew; Thomas, Melissa; Singleton, Marcy; Jarvis, Dean; Nett, Sholeen; Willson, Douglas; Hoot, Michelle; Bembea, Melania; Yiu, Alvin; McKinley, David; Scarlett, Elizabeth; Sankey, Jennifer; Parikh, Minal; Vincent, E.; Faustino, S.; Michelson, Kelly; Rilinger, Jay; Campbell, Laura; Gertz, Shira; Cholette, Jill M.; Jeyapalan, Asumthia; Parker, Margaret; Bateman, Scot; Johnson, Amanda.

In: Annals of Intensive Care, Vol. 6, No. 1, 98, 01.12.2016.

Research output: Contribution to journalArticle

Karam, O, Demaret, P, Duhamel, A, Shefler, A, Spinella, PC, Stanworth, SJ, Tucci, M, Leteurtre, S, for the PlasmaTV investigators, TPVI, Butt, W, Delzoppo, C, Bain, K, Erickson, S, Smalley, N, Dorofaeff, T, Long, D, Wiseman, G, Clénent de Cléty, S, Berghe, C, de Jaeger, A, Demaret, P, Trippaerts, M, Willems, A, Rooze, S, De Dooy, J, Gilfoyle, E, Wohlgemuth, L, Tucci, M, Dumitrascu, M, Withington, D, Hickey, J, Choong, K, Sanders, L, Morrison, G, Tijssen, J, Wensley, D, Krahn, G, Dugas, MA, Gosselin, L, Santschi, M, Von Dessauer, B, Ordenes, N, Afshari, A, Andersen, LH, Nilsson, JC, Johansen, M, Baek Jensen, AM, Campos Mino, S, Grunauer, M, Joram, N, Roullet-Renoleau, N, Javouhey, E, Cour-Andlauer, F, Portefaix, A, Brissaud, O, Guichoux, J, Payen, V, Léger, PL, Afanetti, M, Mortamet, G, Maria, M, Breining, A, Tissieres, P, Dorkenoo, A, Deho, A, Steinherr, H, Nikolaou, F, Camporesi, A, Mario, F, Kawasaki, T, Miura, S, Beca, J, Rea, M, Sherring, C, Bushell, T, Bentsen, G, Dinis, A, Pereira, G, Vieira, M, Moniz, M, Alshehri, S, Alasnag, M, Pisarcikova, M, Jordan, I, Balcells, J, Perez-Ferrer, A, de Vicente Sánchez, J, Vazquez Moyano, M, Morales Martinez, A, Lopez-Herce, J, Solana, MJ, Flores González, JC, Alonso, MT, Nieto Faza, M, Perez, MH, Amiet, V, Doell, C, Bordessoule, A, Cochius-den Otter, S, Kapitein, B, Kneyber, M, Brierley, J, Rea, V, McKeever, S, Kelleher, A, Scholefield, B, Top, A, Kelly, N, Virdee, S, Davis, P, George, S, Hawkins, KC, McCall, K, Brown, V, Sykes, K, Levin, R, MacLeod, I, Horan, M, Jirasek, P, Inwald, D, Abdulla, A, Raghunanan, S, Taylor, B, Shefler, A, Sparkes, H, Hanson, S, Woods, K, Triscari, D, Murkowski, K, Ozment, C, Steiner, M, Nerheim, D, Galster, A, Higgerson, R, Christie, LA, Spinella, PC, Martin, D, Rourke, L, Muszynski, J, Steele, L, Ajizian, S, McCrory, MC, O’Brien, K, Babbitt, C, Felkel, E, Levine, G, Truemper, EJ, Zink, M, Nellis, M, Thomas, NJ, Spear, D, Markovitz, B, Terry, J, Morzov, R, Montgomery, V, Michael, A, Thomas, M, Singleton, M, Jarvis, D, Nett, S, Willson, D, Hoot, M, Bembea, M, Yiu, A, McKinley, D, Scarlett, E, Sankey, J, Parikh, M, Vincent, E, Faustino, S, Michelson, K, Rilinger, J, Campbell, L, Gertz, S, Cholette, JM, Jeyapalan, A, Parker, M, Bateman, S & Johnson, A 2016, 'Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions', Annals of Intensive Care, vol. 6, no. 1, 98. https://doi.org/10.1186/s13613-016-0197-6
Karam, Oliver ; Demaret, Pierre ; Duhamel, Alain ; Shefler, Alison ; Spinella, Philip C. ; Stanworth, Simon J. ; Tucci, Marisa ; Leteurtre, Stéphane ; for the PlasmaTV investigators, the PlasmaTV investigators ; Butt, Warwick ; Delzoppo, Carmel ; Bain, Kym ; Erickson, Simon ; Smalley, Nathan ; Dorofaeff, Tavey ; Long, Debbie ; Wiseman, Greg ; Clénent de Cléty, Stéphan ; Berghe, Caroline ; de Jaeger, Annick ; Demaret, Pierre ; Trippaerts, Marc ; Willems, Ariane ; Rooze, Shancy ; De Dooy, Jozef ; Gilfoyle, Elaine ; Wohlgemuth, Lynette ; Tucci, Marisa ; Dumitrascu, Mariana ; Withington, Davinia ; Hickey, Julia ; Choong, Karen ; Sanders, Lois ; Morrison, Gavin ; Tijssen, Janice ; Wensley, David ; Krahn, Gordon ; Dugas, Marc Andre ; Gosselin, Louise ; Santschi, Miriam ; Von Dessauer, Bettina ; Ordenes, Nadia ; Afshari, Arash ; Andersen, Lasse Hoegh ; Nilsson, Jens Christian ; Johansen, Mathias ; Baek Jensen, Anne Mette ; Campos Mino, Santiago ; Grunauer, Michelle ; Joram, Nicolas ; Roullet-Renoleau, Nicolas ; Javouhey, Etienne ; Cour-Andlauer, Fleur ; Portefaix, Aurélie ; Brissaud, Olivier ; Guichoux, Julie ; Payen, Valérie ; Léger, Pierre Louis ; Afanetti, Mickael ; Mortamet, Guillaume ; Maria, Matthieu ; Breining, Audrey ; Tissieres, Pierre ; Dorkenoo, Aimée ; Deho, Anna ; Steinherr, Harry ; Nikolaou, Filippia ; Camporesi, Anna ; Mario, Federica ; Kawasaki, Tatsuya ; Miura, Shinya ; Beca, John ; Rea, Miriam ; Sherring, Claire ; Bushell, Tracey ; Bentsen, Gunnar ; Dinis, Alexandra ; Pereira, Gabriela ; Vieira, Marisa ; Moniz, Marta ; Alshehri, Saleh ; Alasnag, Manal ; Pisarcikova, Maria ; Jordan, Iolanda ; Balcells, Joan ; Perez-Ferrer, Antonio ; de Vicente Sánchez, Jesús ; Vazquez Moyano, Marta ; Morales Martinez, Antonio ; Lopez-Herce, Jesus ; Solana, Maria Jose ; Flores González, Jose Carlos ; Alonso, Maria Teresa ; Nieto Faza, Manuel ; Perez, Marie Hélène ; Amiet, Vivianne ; Doell, Carsten ; Bordessoule, Alice ; Cochius-den Otter, Suzan ; Kapitein, Berber ; Kneyber, Martin ; Brierley, Joe ; Rea, Vanessa ; McKeever, Stephen ; Kelleher, Andrea ; Scholefield, Barney ; Top, Anke ; Kelly, Nicola ; Virdee, Satnam ; Davis, Peter ; George, Susan ; Hawkins, Kay C. ; McCall, Katie ; Brown, Victoria ; Sykes, Kim ; Levin, Richard ; MacLeod, Isobel ; Horan, Marie ; Jirasek, Petr ; Inwald, David ; Abdulla, Amina ; Raghunanan, Sophie ; Taylor, Bob ; Shefler, Alison ; Sparkes, Hannah ; Hanson, Sheila ; Woods, Katherine ; Triscari, David ; Murkowski, Kathy ; Ozment, Caroline ; Steiner, Marie ; Nerheim, Dan ; Galster, Amanda ; Higgerson, Renee ; Christie, Lee Ann ; Spinella, Philip C. ; Martin, Daniel ; Rourke, Liz ; Muszynski, Jennifer ; Steele, Lisa ; Ajizian, Samuel ; McCrory, Michael C. ; O’Brien, Kevin ; Babbitt, Christopher ; Felkel, Erin ; Levine, Glenn ; Truemper, Edward J. ; Zink, Machelle ; Nellis, Marianne ; Thomas, Neal J. ; Spear, Debbie ; Markovitz, Barry ; Terry, Jeff ; Morzov, Rica ; Montgomery, Vicki ; Michael, Andrew ; Thomas, Melissa ; Singleton, Marcy ; Jarvis, Dean ; Nett, Sholeen ; Willson, Douglas ; Hoot, Michelle ; Bembea, Melania ; Yiu, Alvin ; McKinley, David ; Scarlett, Elizabeth ; Sankey, Jennifer ; Parikh, Minal ; Vincent, E. ; Faustino, S. ; Michelson, Kelly ; Rilinger, Jay ; Campbell, Laura ; Gertz, Shira ; Cholette, Jill M. ; Jeyapalan, Asumthia ; Parker, Margaret ; Bateman, Scot ; Johnson, Amanda. / Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions. In: Annals of Intensive Care. 2016 ; Vol. 6, No. 1.
@article{62b3338326b2483d85b142f497bed7e4,
title = "Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions",
abstract = "Background: Organ dysfunction scores, based on physiological parameters, have been created to describe organ failure. In a general pediatric intensive care unit (PICU) population, the PEdiatric Logistic Organ Dysfunction-2 score (PELOD-2) score had both a good discrimination and calibration, allowing to describe the clinical outcome of critically ill children throughout their stay. This score is increasingly used in clinical trials in specific subpopulation. Our objective was to assess the performance of the PELOD-2 score in a subpopulation of critically ill children requiring plasma transfusions. Methods: This was an ancillary study of a prospective observational study on plasma transfusions over a 6-week period, in 101 PICUs in 21 countries. All critically ill children who received at least one plasma transfusion during the observation period were included. PELOD-2 scores were measured on days 1, 2, 5, 8, and 12 after plasma transfusion. Performance of the score was assessed by the determination of the discrimination (area under the ROC curve: AUC) and the calibration (Hosmer–Lemeshow test). Results: Four hundred and forty-three patients were enrolled in the study (median age and weight: 1 year and 9.1 kg, respectively). Observed mortality rate was 26.9 {\%} (119/443). For PELOD-2 on day 1, the AUC was 0.76 (95 {\%} CI 0.71–0.81) and the Hosmer–Lemeshow test was p = 0.76. The serial evaluation of the changes in the daily PELOD-2 scores from day 1 demonstrated a significant association with death, adjusted for the PELOD-2 score on day 1. Conclusions: In a subpopulation of critically ill children requiring plasma transfusion, the PELOD-2 score has a lower but acceptable discrimination than in an entire population. This score should therefore be used cautiously in this specific subpopulation.",
keywords = "Children, Critical care, Multiple organ failure, Outcome, Plasma transfusion, Score",
author = "Oliver Karam and Pierre Demaret and Alain Duhamel and Alison Shefler and Spinella, {Philip C.} and Stanworth, {Simon J.} and Marisa Tucci and St{\'e}phane Leteurtre and {for the PlasmaTV investigators}, {the PlasmaTV investigators} and Warwick Butt and Carmel Delzoppo and Kym Bain and Simon Erickson and Nathan Smalley and Tavey Dorofaeff and Debbie Long and Greg Wiseman and {Cl{\'e}nent de Cl{\'e}ty}, St{\'e}phan and Caroline Berghe and Annick de Jaeger and Pierre Demaret and Marc Trippaerts and Ariane Willems and Shancy Rooze and Jozef De Dooy and Elaine Gilfoyle and Lynette Wohlgemuth and Marisa Tucci and Mariana Dumitrascu and Davinia Withington and Julia Hickey and Karen Choong and Lois Sanders and Gavin Morrison and Janice Tijssen and David Wensley and Gordon Krahn and Dugas, {Marc Andre} and Louise Gosselin and Miriam Santschi and Bettina Von Dessauer and Nadia Ordenes and Arash Afshari and Andersen, {Lasse Hoegh} and Nilsson, {Jens Christian} and Mathias Johansen and Baek Jensen, {Anne Mette} and Santiago Campos Mino and Michelle Grunauer and Nicolas Joram and Nicolas Roullet-Renoleau and Etienne Javouhey and Fleur Cour-Andlauer and Aur{\'e}lie Portefaix and Olivier Brissaud and Julie Guichoux and Val{\'e}rie Payen and L{\'e}ger, {Pierre Louis} and Mickael Afanetti and Guillaume Mortamet and Matthieu Maria and Audrey Breining and Pierre Tissieres and Aim{\'e}e Dorkenoo and Anna Deho and Harry Steinherr and Filippia Nikolaou and Anna Camporesi and Federica Mario and Tatsuya Kawasaki and Shinya Miura and John Beca and Miriam Rea and Claire Sherring and Tracey Bushell and Gunnar Bentsen and Alexandra Dinis and Gabriela Pereira and Marisa Vieira and Marta Moniz and Saleh Alshehri and Manal Alasnag and Maria Pisarcikova and Iolanda Jordan and Joan Balcells and Antonio Perez-Ferrer and {de Vicente S{\'a}nchez}, Jes{\'u}s and Marta Vazquez Moyano and Antonio Morales Martinez and Jesus Lopez-Herce and Solana, {Maria Jose} and Flores Gonz{\'a}lez, {Jose Carlos} and Alonso, {Maria Teresa} and Manuel Nieto Faza and Perez, {Marie H{\'e}l{\`e}ne} and Vivianne Amiet and Carsten Doell and Alice Bordessoule and {Cochius-den Otter}, Suzan and Berber Kapitein and Martin Kneyber and Joe Brierley and Vanessa Rea and Stephen McKeever and Andrea Kelleher and Barney Scholefield and Anke Top and Nicola Kelly and Satnam Virdee and Peter Davis and Susan George and Hawkins, {Kay C.} and Katie McCall and Victoria Brown and Kim Sykes and Richard Levin and Isobel MacLeod and Marie Horan and Petr Jirasek and David Inwald and Amina Abdulla and Sophie Raghunanan and Bob Taylor and Alison Shefler and Hannah Sparkes and Sheila Hanson and Katherine Woods and David Triscari and Kathy Murkowski and Caroline Ozment and Marie Steiner and Dan Nerheim and Amanda Galster and Renee Higgerson and Christie, {Lee Ann} and Spinella, {Philip C.} and Daniel Martin and Liz Rourke and Jennifer Muszynski and Lisa Steele and Samuel Ajizian and McCrory, {Michael C.} and Kevin O’Brien and Christopher Babbitt and Erin Felkel and Glenn Levine and Truemper, {Edward J.} and Machelle Zink and Marianne Nellis and Thomas, {Neal J.} and Debbie Spear and Barry Markovitz and Jeff Terry and Rica Morzov and Vicki Montgomery and Andrew Michael and Melissa Thomas and Marcy Singleton and Dean Jarvis and Sholeen Nett and Douglas Willson and Michelle Hoot and Melania Bembea and Alvin Yiu and David McKinley and Elizabeth Scarlett and Jennifer Sankey and Minal Parikh and E. Vincent and S. Faustino and Kelly Michelson and Jay Rilinger and Laura Campbell and Shira Gertz and Cholette, {Jill M.} and Asumthia Jeyapalan and Margaret Parker and Scot Bateman and Amanda Johnson",
year = "2016",
month = "12",
day = "1",
doi = "10.1186/s13613-016-0197-6",
language = "English (US)",
volume = "6",
journal = "Annals of Intensive Care",
issn = "2110-5820",
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TY - JOUR

T1 - Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions

AU - Karam, Oliver

AU - Demaret, Pierre

AU - Duhamel, Alain

AU - Shefler, Alison

AU - Spinella, Philip C.

AU - Stanworth, Simon J.

AU - Tucci, Marisa

AU - Leteurtre, Stéphane

AU - for the PlasmaTV investigators, the PlasmaTV investigators

AU - Butt, Warwick

AU - Delzoppo, Carmel

AU - Bain, Kym

AU - Erickson, Simon

AU - Smalley, Nathan

AU - Dorofaeff, Tavey

AU - Long, Debbie

AU - Wiseman, Greg

AU - Clénent de Cléty, Stéphan

AU - Berghe, Caroline

AU - de Jaeger, Annick

AU - Demaret, Pierre

AU - Trippaerts, Marc

AU - Willems, Ariane

AU - Rooze, Shancy

AU - De Dooy, Jozef

AU - Gilfoyle, Elaine

AU - Wohlgemuth, Lynette

AU - Tucci, Marisa

AU - Dumitrascu, Mariana

AU - Withington, Davinia

AU - Hickey, Julia

AU - Choong, Karen

AU - Sanders, Lois

AU - Morrison, Gavin

AU - Tijssen, Janice

AU - Wensley, David

AU - Krahn, Gordon

AU - Dugas, Marc Andre

AU - Gosselin, Louise

AU - Santschi, Miriam

AU - Von Dessauer, Bettina

AU - Ordenes, Nadia

AU - Afshari, Arash

AU - Andersen, Lasse Hoegh

AU - Nilsson, Jens Christian

AU - Johansen, Mathias

AU - Baek Jensen, Anne Mette

AU - Campos Mino, Santiago

AU - Grunauer, Michelle

AU - Joram, Nicolas

AU - Roullet-Renoleau, Nicolas

AU - Javouhey, Etienne

AU - Cour-Andlauer, Fleur

AU - Portefaix, Aurélie

AU - Brissaud, Olivier

AU - Guichoux, Julie

AU - Payen, Valérie

AU - Léger, Pierre Louis

AU - Afanetti, Mickael

AU - Mortamet, Guillaume

AU - Maria, Matthieu

AU - Breining, Audrey

AU - Tissieres, Pierre

AU - Dorkenoo, Aimée

AU - Deho, Anna

AU - Steinherr, Harry

AU - Nikolaou, Filippia

AU - Camporesi, Anna

AU - Mario, Federica

AU - Kawasaki, Tatsuya

AU - Miura, Shinya

AU - Beca, John

AU - Rea, Miriam

AU - Sherring, Claire

AU - Bushell, Tracey

AU - Bentsen, Gunnar

AU - Dinis, Alexandra

AU - Pereira, Gabriela

AU - Vieira, Marisa

AU - Moniz, Marta

AU - Alshehri, Saleh

AU - Alasnag, Manal

AU - Pisarcikova, Maria

AU - Jordan, Iolanda

AU - Balcells, Joan

AU - Perez-Ferrer, Antonio

AU - de Vicente Sánchez, Jesús

AU - Vazquez Moyano, Marta

AU - Morales Martinez, Antonio

AU - Lopez-Herce, Jesus

AU - Solana, Maria Jose

AU - Flores González, Jose Carlos

AU - Alonso, Maria Teresa

AU - Nieto Faza, Manuel

AU - Perez, Marie Hélène

AU - Amiet, Vivianne

AU - Doell, Carsten

AU - Bordessoule, Alice

AU - Cochius-den Otter, Suzan

AU - Kapitein, Berber

AU - Kneyber, Martin

AU - Brierley, Joe

AU - Rea, Vanessa

AU - McKeever, Stephen

AU - Kelleher, Andrea

AU - Scholefield, Barney

AU - Top, Anke

AU - Kelly, Nicola

AU - Virdee, Satnam

AU - Davis, Peter

AU - George, Susan

AU - Hawkins, Kay C.

AU - McCall, Katie

AU - Brown, Victoria

AU - Sykes, Kim

AU - Levin, Richard

AU - MacLeod, Isobel

AU - Horan, Marie

AU - Jirasek, Petr

AU - Inwald, David

AU - Abdulla, Amina

AU - Raghunanan, Sophie

AU - Taylor, Bob

AU - Shefler, Alison

AU - Sparkes, Hannah

AU - Hanson, Sheila

AU - Woods, Katherine

AU - Triscari, David

AU - Murkowski, Kathy

AU - Ozment, Caroline

AU - Steiner, Marie

AU - Nerheim, Dan

AU - Galster, Amanda

AU - Higgerson, Renee

AU - Christie, Lee Ann

AU - Spinella, Philip C.

AU - Martin, Daniel

AU - Rourke, Liz

AU - Muszynski, Jennifer

AU - Steele, Lisa

AU - Ajizian, Samuel

AU - McCrory, Michael C.

AU - O’Brien, Kevin

AU - Babbitt, Christopher

AU - Felkel, Erin

AU - Levine, Glenn

AU - Truemper, Edward J.

AU - Zink, Machelle

AU - Nellis, Marianne

AU - Thomas, Neal J.

AU - Spear, Debbie

AU - Markovitz, Barry

AU - Terry, Jeff

AU - Morzov, Rica

AU - Montgomery, Vicki

AU - Michael, Andrew

AU - Thomas, Melissa

AU - Singleton, Marcy

AU - Jarvis, Dean

AU - Nett, Sholeen

AU - Willson, Douglas

AU - Hoot, Michelle

AU - Bembea, Melania

AU - Yiu, Alvin

AU - McKinley, David

AU - Scarlett, Elizabeth

AU - Sankey, Jennifer

AU - Parikh, Minal

AU - Vincent, E.

AU - Faustino, S.

AU - Michelson, Kelly

AU - Rilinger, Jay

AU - Campbell, Laura

AU - Gertz, Shira

AU - Cholette, Jill M.

AU - Jeyapalan, Asumthia

AU - Parker, Margaret

AU - Bateman, Scot

AU - Johnson, Amanda

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Background: Organ dysfunction scores, based on physiological parameters, have been created to describe organ failure. In a general pediatric intensive care unit (PICU) population, the PEdiatric Logistic Organ Dysfunction-2 score (PELOD-2) score had both a good discrimination and calibration, allowing to describe the clinical outcome of critically ill children throughout their stay. This score is increasingly used in clinical trials in specific subpopulation. Our objective was to assess the performance of the PELOD-2 score in a subpopulation of critically ill children requiring plasma transfusions. Methods: This was an ancillary study of a prospective observational study on plasma transfusions over a 6-week period, in 101 PICUs in 21 countries. All critically ill children who received at least one plasma transfusion during the observation period were included. PELOD-2 scores were measured on days 1, 2, 5, 8, and 12 after plasma transfusion. Performance of the score was assessed by the determination of the discrimination (area under the ROC curve: AUC) and the calibration (Hosmer–Lemeshow test). Results: Four hundred and forty-three patients were enrolled in the study (median age and weight: 1 year and 9.1 kg, respectively). Observed mortality rate was 26.9 % (119/443). For PELOD-2 on day 1, the AUC was 0.76 (95 % CI 0.71–0.81) and the Hosmer–Lemeshow test was p = 0.76. The serial evaluation of the changes in the daily PELOD-2 scores from day 1 demonstrated a significant association with death, adjusted for the PELOD-2 score on day 1. Conclusions: In a subpopulation of critically ill children requiring plasma transfusion, the PELOD-2 score has a lower but acceptable discrimination than in an entire population. This score should therefore be used cautiously in this specific subpopulation.

AB - Background: Organ dysfunction scores, based on physiological parameters, have been created to describe organ failure. In a general pediatric intensive care unit (PICU) population, the PEdiatric Logistic Organ Dysfunction-2 score (PELOD-2) score had both a good discrimination and calibration, allowing to describe the clinical outcome of critically ill children throughout their stay. This score is increasingly used in clinical trials in specific subpopulation. Our objective was to assess the performance of the PELOD-2 score in a subpopulation of critically ill children requiring plasma transfusions. Methods: This was an ancillary study of a prospective observational study on plasma transfusions over a 6-week period, in 101 PICUs in 21 countries. All critically ill children who received at least one plasma transfusion during the observation period were included. PELOD-2 scores were measured on days 1, 2, 5, 8, and 12 after plasma transfusion. Performance of the score was assessed by the determination of the discrimination (area under the ROC curve: AUC) and the calibration (Hosmer–Lemeshow test). Results: Four hundred and forty-three patients were enrolled in the study (median age and weight: 1 year and 9.1 kg, respectively). Observed mortality rate was 26.9 % (119/443). For PELOD-2 on day 1, the AUC was 0.76 (95 % CI 0.71–0.81) and the Hosmer–Lemeshow test was p = 0.76. The serial evaluation of the changes in the daily PELOD-2 scores from day 1 demonstrated a significant association with death, adjusted for the PELOD-2 score on day 1. Conclusions: In a subpopulation of critically ill children requiring plasma transfusion, the PELOD-2 score has a lower but acceptable discrimination than in an entire population. This score should therefore be used cautiously in this specific subpopulation.

KW - Children

KW - Critical care

KW - Multiple organ failure

KW - Outcome

KW - Plasma transfusion

KW - Score

UR - http://www.scopus.com/inward/record.url?scp=84991228902&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84991228902&partnerID=8YFLogxK

U2 - 10.1186/s13613-016-0197-6

DO - 10.1186/s13613-016-0197-6

M3 - Article

C2 - 27714707

AN - SCOPUS:84991228902

VL - 6

JO - Annals of Intensive Care

JF - Annals of Intensive Care

SN - 2110-5820

IS - 1

M1 - 98

ER -