Pentobarbital potentiates natriuretic response to acute volume expansion in monkeys

J. P. Gilmore, Kurtis G Cornish, M. W. Barazanji

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We determined the influence of pentobarbital sodium on the renal responses of the monkey to acute intravascular volume expansion. Before volume expansion, the anesthetized animals had a significantly lower blood pressure and creatinine clearance and a significantly higher urine flow and sodium excretion than the conscious animals. After volume expansion with an isotonic, isoncotic, dextran solution, sodium excretion and urine flow increased significantly in both groups of animals. However, both responses were significantly greater in the anesthetized animals. The greater natriuresis in the anesthetized animals was associated with a greater fractional sodium excretion than in the conscious animals. The potentiated response of the anesthetized animal may be the result of a direct renal tubular effect of pentobarbital and/or the result of the anesthetic removing an inhibitory influence on sodium excretion.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume254
Issue number5
StatePublished - Jan 1 1988

Fingerprint

Pentobarbital
Haplorhini
Sodium
Urine
Kidney
Natriuresis
Dextrans
Anesthetics
Creatinine
Blood Pressure

ASJC Scopus subject areas

  • Physiology

Cite this

Pentobarbital potentiates natriuretic response to acute volume expansion in monkeys. / Gilmore, J. P.; Cornish, Kurtis G; Barazanji, M. W.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 254, No. 5, 01.01.1988.

Research output: Contribution to journalArticle

@article{b7fc60225f694051b576fdf26de53d93,
title = "Pentobarbital potentiates natriuretic response to acute volume expansion in monkeys",
abstract = "We determined the influence of pentobarbital sodium on the renal responses of the monkey to acute intravascular volume expansion. Before volume expansion, the anesthetized animals had a significantly lower blood pressure and creatinine clearance and a significantly higher urine flow and sodium excretion than the conscious animals. After volume expansion with an isotonic, isoncotic, dextran solution, sodium excretion and urine flow increased significantly in both groups of animals. However, both responses were significantly greater in the anesthetized animals. The greater natriuresis in the anesthetized animals was associated with a greater fractional sodium excretion than in the conscious animals. The potentiated response of the anesthetized animal may be the result of a direct renal tubular effect of pentobarbital and/or the result of the anesthetic removing an inhibitory influence on sodium excretion.",
author = "Gilmore, {J. P.} and Cornish, {Kurtis G} and Barazanji, {M. W.}",
year = "1988",
month = "1",
day = "1",
language = "English (US)",
volume = "254",
journal = "American Journal of Physiology - Renal Physiology",
issn = "0363-6127",
publisher = "American Physiological Society",
number = "5",

}

TY - JOUR

T1 - Pentobarbital potentiates natriuretic response to acute volume expansion in monkeys

AU - Gilmore, J. P.

AU - Cornish, Kurtis G

AU - Barazanji, M. W.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - We determined the influence of pentobarbital sodium on the renal responses of the monkey to acute intravascular volume expansion. Before volume expansion, the anesthetized animals had a significantly lower blood pressure and creatinine clearance and a significantly higher urine flow and sodium excretion than the conscious animals. After volume expansion with an isotonic, isoncotic, dextran solution, sodium excretion and urine flow increased significantly in both groups of animals. However, both responses were significantly greater in the anesthetized animals. The greater natriuresis in the anesthetized animals was associated with a greater fractional sodium excretion than in the conscious animals. The potentiated response of the anesthetized animal may be the result of a direct renal tubular effect of pentobarbital and/or the result of the anesthetic removing an inhibitory influence on sodium excretion.

AB - We determined the influence of pentobarbital sodium on the renal responses of the monkey to acute intravascular volume expansion. Before volume expansion, the anesthetized animals had a significantly lower blood pressure and creatinine clearance and a significantly higher urine flow and sodium excretion than the conscious animals. After volume expansion with an isotonic, isoncotic, dextran solution, sodium excretion and urine flow increased significantly in both groups of animals. However, both responses were significantly greater in the anesthetized animals. The greater natriuresis in the anesthetized animals was associated with a greater fractional sodium excretion than in the conscious animals. The potentiated response of the anesthetized animal may be the result of a direct renal tubular effect of pentobarbital and/or the result of the anesthetic removing an inhibitory influence on sodium excretion.

UR - http://www.scopus.com/inward/record.url?scp=0023895379&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023895379&partnerID=8YFLogxK

M3 - Article

VL - 254

JO - American Journal of Physiology - Renal Physiology

JF - American Journal of Physiology - Renal Physiology

SN - 0363-6127

IS - 5

ER -