Penicillin-Intermediate Pneumococci in a Children's Hospital

Lynne D Willett, Hugh C. Dillon, Barry M. Gray

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

During the three-year period from 1981 to 1984, all clinical isolates of Streptococcus pneumoniae were screened for resistance to penicillin in the clinical bacteriology laboratory at The Children's Hospital of Alabama, Birmingham. Twenty-eight of 828 isolates were presumed resistant by disk diffusion testing with 1-μg oxacillin disks Seventeen of the 28 were found to be intermediately sensitive to penicillin by a conventional agar dilution method. Penicillin-intermediate strains had a minimal inhibitory concentration of 0.125 to 0.5 mg/L; no penicillin-resistant strains were encountered. The prevalence of penicillin-intermediate strains was thus 17 of 828 isolates, or 2.1%. These strains were also examined for susceptibility to ampicillin, vancomycin, cefotaxime, and chloramphenicol. We present the clinical features of 17 patients with disease due to penicillin-intermediate pneumococci.

Original languageEnglish (US)
Pages (from-to)1054-1057
Number of pages4
JournalAmerican Journal of Diseases of Children
Volume139
Issue number10
DOIs
StatePublished - Oct 1985

Fingerprint

Streptococcus pneumoniae
Penicillins
Penicillin Resistance
Oxacillin
Bacteriology
Cefotaxime
Chloramphenicol
Vancomycin
Ampicillin
Agar

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Penicillin-Intermediate Pneumococci in a Children's Hospital. / Willett, Lynne D; Dillon, Hugh C.; Gray, Barry M.

In: American Journal of Diseases of Children, Vol. 139, No. 10, 10.1985, p. 1054-1057.

Research output: Contribution to journalArticle

Willett, Lynne D ; Dillon, Hugh C. ; Gray, Barry M. / Penicillin-Intermediate Pneumococci in a Children's Hospital. In: American Journal of Diseases of Children. 1985 ; Vol. 139, No. 10. pp. 1054-1057.
@article{c8552bd9899e4fc49a6a313435756392,
title = "Penicillin-Intermediate Pneumococci in a Children's Hospital",
abstract = "During the three-year period from 1981 to 1984, all clinical isolates of Streptococcus pneumoniae were screened for resistance to penicillin in the clinical bacteriology laboratory at The Children's Hospital of Alabama, Birmingham. Twenty-eight of 828 isolates were presumed resistant by disk diffusion testing with 1-μg oxacillin disks Seventeen of the 28 were found to be intermediately sensitive to penicillin by a conventional agar dilution method. Penicillin-intermediate strains had a minimal inhibitory concentration of 0.125 to 0.5 mg/L; no penicillin-resistant strains were encountered. The prevalence of penicillin-intermediate strains was thus 17 of 828 isolates, or 2.1{\%}. These strains were also examined for susceptibility to ampicillin, vancomycin, cefotaxime, and chloramphenicol. We present the clinical features of 17 patients with disease due to penicillin-intermediate pneumococci.",
author = "Willett, {Lynne D} and Dillon, {Hugh C.} and Gray, {Barry M.}",
year = "1985",
month = "10",
doi = "10.1001/archpedi.1985.02140120100037",
language = "English (US)",
volume = "139",
pages = "1054--1057",
journal = "JAMA Pediatrics",
issn = "2168-6203",
publisher = "American Medical Association",
number = "10",

}

TY - JOUR

T1 - Penicillin-Intermediate Pneumococci in a Children's Hospital

AU - Willett, Lynne D

AU - Dillon, Hugh C.

AU - Gray, Barry M.

PY - 1985/10

Y1 - 1985/10

N2 - During the three-year period from 1981 to 1984, all clinical isolates of Streptococcus pneumoniae were screened for resistance to penicillin in the clinical bacteriology laboratory at The Children's Hospital of Alabama, Birmingham. Twenty-eight of 828 isolates were presumed resistant by disk diffusion testing with 1-μg oxacillin disks Seventeen of the 28 were found to be intermediately sensitive to penicillin by a conventional agar dilution method. Penicillin-intermediate strains had a minimal inhibitory concentration of 0.125 to 0.5 mg/L; no penicillin-resistant strains were encountered. The prevalence of penicillin-intermediate strains was thus 17 of 828 isolates, or 2.1%. These strains were also examined for susceptibility to ampicillin, vancomycin, cefotaxime, and chloramphenicol. We present the clinical features of 17 patients with disease due to penicillin-intermediate pneumococci.

AB - During the three-year period from 1981 to 1984, all clinical isolates of Streptococcus pneumoniae were screened for resistance to penicillin in the clinical bacteriology laboratory at The Children's Hospital of Alabama, Birmingham. Twenty-eight of 828 isolates were presumed resistant by disk diffusion testing with 1-μg oxacillin disks Seventeen of the 28 were found to be intermediately sensitive to penicillin by a conventional agar dilution method. Penicillin-intermediate strains had a minimal inhibitory concentration of 0.125 to 0.5 mg/L; no penicillin-resistant strains were encountered. The prevalence of penicillin-intermediate strains was thus 17 of 828 isolates, or 2.1%. These strains were also examined for susceptibility to ampicillin, vancomycin, cefotaxime, and chloramphenicol. We present the clinical features of 17 patients with disease due to penicillin-intermediate pneumococci.

UR - http://www.scopus.com/inward/record.url?scp=0022413952&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022413952&partnerID=8YFLogxK

U2 - 10.1001/archpedi.1985.02140120100037

DO - 10.1001/archpedi.1985.02140120100037

M3 - Article

C2 - 4036893

AN - SCOPUS:0022413952

VL - 139

SP - 1054

EP - 1057

JO - JAMA Pediatrics

JF - JAMA Pediatrics

SN - 2168-6203

IS - 10

ER -