Penetration of neuronal perikarya by capillaries in chronic limbic encephalitis

John J. Kepes, Julia Ann Bridge, Janine Flasschoen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In a case of chronic limbic encephalitis in a 5 7-year-old man many neurons in the pyramidal cell layer of the hippocampus bilaterally were penetrated by ingrowing capillaries. All gradations from slight to moderate indentation of the cell membranes to complete incorporation of the capillaries in the neuronal perikarya were observed. The penetrating capillaries retained their basement membranes. Because of the chronic inflammation there was extensive fibrous gliosis in Ammon’s horn. This apparently had an immobilizing effect on these neurons; it is postulated that proliferating capillaries of the active inflammatory process were unable to displace local neurons and instead grew against and through their perikarya.

Original languageEnglish (US)
Pages (from-to)64-70
Number of pages7
JournalJournal of Neuropathology and Experimental Neurology
Volume49
Issue number1
DOIs
StatePublished - Jan 1 1990

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Limbic Encephalitis
Neurons
Hippocampus
Gliosis
Pyramidal Cells
Basement Membrane
Cell Membrane
Inflammation

Keywords

  • Capillary
  • Limbic encephalitis Chronic
  • Neurons

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Penetration of neuronal perikarya by capillaries in chronic limbic encephalitis. / Kepes, John J.; Bridge, Julia Ann; Flasschoen, Janine.

In: Journal of Neuropathology and Experimental Neurology, Vol. 49, No. 1, 01.01.1990, p. 64-70.

Research output: Contribution to journalArticle

Kepes, John J. ; Bridge, Julia Ann ; Flasschoen, Janine. / Penetration of neuronal perikarya by capillaries in chronic limbic encephalitis. In: Journal of Neuropathology and Experimental Neurology. 1990 ; Vol. 49, No. 1. pp. 64-70.
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