Pediatric Orofacial and Laryngopharyngeal Rhabdomyosarcoma: An Intergroup Rhabdomyosarcoma Study Report

Moody D. Wharam, Mohan S. Beltangady, Ruth M. Heyn, Walter Lawrence, R. Beverly Raney, Frederick B. Ruymann, Edward H. Soule, Melvin Tefft, Harold M. Maurer

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34 Citations (Scopus)

Abstract

Eighty-nine children with localized rhabdomyosarcoma of orofacial and laryngopharyngeal sites were treated in accordance with the first and second Intergroup Rhabdomyosarcoma Study (IRS) protocols (IRS-I and IRS-II) between 1972 and 1984. Treatment included surgery (or biopsy) and chemotherapy for all patients and radiotherapy in the majority. The actuarial estimate of the three-year survival rate for all patients was 83% and did not differ significantly by primary site, histologic findings, or presence of adenopathy. A trend for a worse survival rate was seen in clinical group III patients and in those less than 5 years of age at diagnosis. Factors associated with an increased risk of local/regional relapse included omission of radiotherapy and a radiation dose of less than 40 Gy (4000 rad). We conclude that treatment of these patients as recommended in the IRS-I and IRS-II protocols results in very good local and regional tumor control and survival rates. Salvage therapy for local/regional recurrence may yield long-term remission and possibly cure.

Original languageEnglish (US)
Pages (from-to)1225-1227
Number of pages3
JournalArchives of Otolaryngology--Head and Neck Surgery
Volume113
Issue number11
DOIs
StatePublished - Nov 1987

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Rhabdomyosarcoma
Pediatrics
Survival Rate
Radiotherapy
Recurrence
Salvage Therapy
Radiation
Biopsy
Drug Therapy
Therapeutics
Neoplasms

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

Cite this

Wharam, M. D., Beltangady, M. S., Heyn, R. M., Lawrence, W., Raney, R. B., Ruymann, F. B., ... Maurer, H. M. (1987). Pediatric Orofacial and Laryngopharyngeal Rhabdomyosarcoma: An Intergroup Rhabdomyosarcoma Study Report. Archives of Otolaryngology--Head and Neck Surgery, 113(11), 1225-1227. https://doi.org/10.1001/archotol.1987.01860110091014

Pediatric Orofacial and Laryngopharyngeal Rhabdomyosarcoma : An Intergroup Rhabdomyosarcoma Study Report. / Wharam, Moody D.; Beltangady, Mohan S.; Heyn, Ruth M.; Lawrence, Walter; Raney, R. Beverly; Ruymann, Frederick B.; Soule, Edward H.; Tefft, Melvin; Maurer, Harold M.

In: Archives of Otolaryngology--Head and Neck Surgery, Vol. 113, No. 11, 11.1987, p. 1225-1227.

Research output: Contribution to journalArticle

Wharam, MD, Beltangady, MS, Heyn, RM, Lawrence, W, Raney, RB, Ruymann, FB, Soule, EH, Tefft, M & Maurer, HM 1987, 'Pediatric Orofacial and Laryngopharyngeal Rhabdomyosarcoma: An Intergroup Rhabdomyosarcoma Study Report', Archives of Otolaryngology--Head and Neck Surgery, vol. 113, no. 11, pp. 1225-1227. https://doi.org/10.1001/archotol.1987.01860110091014
Wharam, Moody D. ; Beltangady, Mohan S. ; Heyn, Ruth M. ; Lawrence, Walter ; Raney, R. Beverly ; Ruymann, Frederick B. ; Soule, Edward H. ; Tefft, Melvin ; Maurer, Harold M. / Pediatric Orofacial and Laryngopharyngeal Rhabdomyosarcoma : An Intergroup Rhabdomyosarcoma Study Report. In: Archives of Otolaryngology--Head and Neck Surgery. 1987 ; Vol. 113, No. 11. pp. 1225-1227.
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