Peak SIV replication in resting memory CD4 + T cells depletes gut lamina propria CD4 + T cells

Qingsheng Li, Lijie Dua, Jacob D. Estes, Zhong Min Ma, Tracy Rourke, Yichuan Wang, Cavan Reilly, John Carlis, Christopher J. Miller, Ashley T. Haase

Research output: Contribution to journalArticle

766 Citations (Scopus)

Abstract

In early simian immunodeficiency virus (SIV) and human immunodeficiency virus-1 (HIV-1) infections, gut-associated lymphatic tissue (GALT), the largest component of the lymphoid organ system, is a principal site of both virus production and depletion of primarily lamina propria memory CD4 + T cells; that is, CD4-expressing T cells that previously encountered antigens and microbes and homed to the lamina propria of GALT. Here, we show that peak virus production in gut tissues of SIV-infected rhesus macaques coincides with peak numbers of infected memory CD4 + T cells. Surprisingly, most of the initially infected memory cells were not, as expected, activated but were instead immunophenotypically 'resting' cells that, unlike truly resting cells, but like the first cells mainly infected at other mucosal sites and peripheral lymph nodes, are capable of supporting virus production. In addition to inducing immune activation and thereby providing activated CD4 + T-cell targets to sustain infection, virus production also triggered an immunopathologically limiting Fas-Fas-ligand-mediated apoptotic pathway in lamina propria CD4 + T cells, resulting in their preferential ablation. Thus, SIV exploits a large, resident population of resting memory CD4 + T cells in GALT to produce peak levels of virus that directly (through lytic infection) and indirectly (through apoptosis of infected and uninfected cells) deplete CD4 + T cells in the effector arm of GALT. The scale of this CD4 + T-cell depletion has adverse effects on the immune system of the host, underscoring the importance of developing counter-measures to SFV that are effective before infection of GALT.

Original languageEnglish (US)
Pages (from-to)1148-1152
Number of pages5
JournalNature
Volume434
Issue number7037
DOIs
StatePublished - Apr 28 2005

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Simian Immunodeficiency Virus
Virus Replication
Mucous Membrane
Lymphoid Tissue
T-Lymphocytes
Viruses
Virus Diseases
Fas Ligand Protein
Infection
Macaca mulatta
HIV-1
Immune System
Lymph Nodes
Apoptosis
Antigens

ASJC Scopus subject areas

  • General

Cite this

Li, Q., Dua, L., Estes, J. D., Ma, Z. M., Rourke, T., Wang, Y., ... Haase, A. T. (2005). Peak SIV replication in resting memory CD4 + T cells depletes gut lamina propria CD4 + T cells Nature, 434(7037), 1148-1152. https://doi.org/10.1038/nature03513

Peak SIV replication in resting memory CD4 + T cells depletes gut lamina propria CD4 + T cells . / Li, Qingsheng; Dua, Lijie; Estes, Jacob D.; Ma, Zhong Min; Rourke, Tracy; Wang, Yichuan; Reilly, Cavan; Carlis, John; Miller, Christopher J.; Haase, Ashley T.

In: Nature, Vol. 434, No. 7037, 28.04.2005, p. 1148-1152.

Research output: Contribution to journalArticle

Li, Q, Dua, L, Estes, JD, Ma, ZM, Rourke, T, Wang, Y, Reilly, C, Carlis, J, Miller, CJ & Haase, AT 2005, ' Peak SIV replication in resting memory CD4 + T cells depletes gut lamina propria CD4 + T cells ', Nature, vol. 434, no. 7037, pp. 1148-1152. https://doi.org/10.1038/nature03513
Li, Qingsheng ; Dua, Lijie ; Estes, Jacob D. ; Ma, Zhong Min ; Rourke, Tracy ; Wang, Yichuan ; Reilly, Cavan ; Carlis, John ; Miller, Christopher J. ; Haase, Ashley T. / Peak SIV replication in resting memory CD4 + T cells depletes gut lamina propria CD4 + T cells In: Nature. 2005 ; Vol. 434, No. 7037. pp. 1148-1152.
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