PDGF/PDGFR axis in the neural systems

Susmita Sil, Palsamy Periyasamy, Annadurai Thangaraj, Ernest T. Chivero, Shilpa J Buch

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are expressed in several cell types including the brain cells such as neuronal progenitors, neurons, astrocytes, and oligodendrocytes. Emerging evidence shows that PDGF-mediated signaling regulates diverse functions in the central nervous system (CNS) such as neurogenesis, cell survival, synaptogenesis, modulation of ligand-gated ion channels, and development of specific types of neurons. Interestingly, PDGF/PDFGR signaling can elicit paradoxical roles in the CNS, depending on the cell type and the activation stimuli and is implicated in the pathogenesis of various neurodegenerative diseases. This review summarizes the role of PDGFs/PDGFRs in several neurodegenerative diseases such as Alzheimer disease, Parkinson disease, amyotrophic lateral sclerosis, brain cancer, cerebral ischemia, HIV-1 and drug abuse. Understanding PDGF/PDGFR signaling may lead to novel approaches for the future development of therapeutic strategies for combating CNS pathologies.

Original languageEnglish (US)
Pages (from-to)63-74
Number of pages12
JournalMolecular Aspects of Medicine
Volume62
DOIs
StatePublished - Aug 2018

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Platelet-Derived Growth Factor Receptors
Platelet-Derived Growth Factor
Neurology
Neurodegenerative diseases
Central Nervous System
Neurodegenerative Diseases
Neurons
Brain
Ligand-Gated Ion Channels
Neurogenesis
Oligodendroglia
Amyotrophic Lateral Sclerosis
Pathology
Brain Ischemia
Brain Neoplasms
Astrocytes
Substance-Related Disorders
Parkinson Disease
HIV-1
Cell Survival

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry

Cite this

PDGF/PDGFR axis in the neural systems. / Sil, Susmita; Periyasamy, Palsamy; Thangaraj, Annadurai; Chivero, Ernest T.; Buch, Shilpa J.

In: Molecular Aspects of Medicine, Vol. 62, 08.2018, p. 63-74.

Research output: Contribution to journalReview article

Sil, S, Periyasamy, P, Thangaraj, A, Chivero, ET & Buch, SJ 2018, 'PDGF/PDGFR axis in the neural systems', Molecular Aspects of Medicine, vol. 62, pp. 63-74. https://doi.org/10.1016/j.mam.2018.01.006
Sil, Susmita ; Periyasamy, Palsamy ; Thangaraj, Annadurai ; Chivero, Ernest T. ; Buch, Shilpa J. / PDGF/PDGFR axis in the neural systems. In: Molecular Aspects of Medicine. 2018 ; Vol. 62. pp. 63-74.
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