Patterns of uterine activity after intravaginal prostaglandin E2 during preinduction cervical ripening

Ann M. Miller, William F. Rayburn, Carl Vernon Smith

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

In a randomized study, uterine activity patterns were characterized with a portable pressure-sensitive device in 40 nonlaboring women at term with an unfavorable cervix who were undergoing preinduction cervical ripening with prostaglandin E2. The prostaglandin E2 was inserted into the posterior vaginal fornix as a single dose of either a 2.5 mg methylcellulose gel (20 cases) or 10 mg controlled-release pessary (20 cases). Uterine activity monitoring began 1 hour before dosing and continued for 12 hours. For those treated with the gel, low-amplitude, high-frequency contractions began within the first hour, reached a peak within 4 hours, and initiated sustained high-amplitude contractions in 10 (50%) cases. With the controlled-release pessary, low-amplitude, high-frequency contractions had a slightly later onset, reached a peak between the fifth and eighth hours, and initiated sustained high-amplitude contractions in 18 (80%) cases. Uterine hyperstimulation occurred in two (10%) pessary cases, with no adverse effect after removal. We conclude that low-amplitude, high-frequency uterine contractions began with either method of intravaginal prostaglandin E2 delivery but led to sustained, high-amplitude contractions primarily with the pessary.

Original languageEnglish (US)
Pages (from-to)1006-1009
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Volume165
Issue number4 PART 1
DOIs
StatePublished - Jan 1 1991

Fingerprint

Cervical Ripening
Pessaries
Dinoprostone
Uterine Monitoring
Gels
Uterine Contraction
Methylcellulose
Cervix Uteri
Pressure
Equipment and Supplies

Keywords

  • Uterine activity
  • cervical ripening
  • prostaglandin E

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Patterns of uterine activity after intravaginal prostaglandin E2 during preinduction cervical ripening. / Miller, Ann M.; Rayburn, William F.; Smith, Carl Vernon.

In: American Journal of Obstetrics and Gynecology, Vol. 165, No. 4 PART 1, 01.01.1991, p. 1006-1009.

Research output: Contribution to journalArticle

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