Patterns of care in pediatric craniopharyngioma

Outcomes following definitive radiotherapy

Tanner K. Hill, Michael J. Baine, Vivek Verma, Morshed Alam, Elizabeth R. Lyden, Chi Lin, Eileen P. Connolly, Chi Zhang

Research output: Contribution to journalArticle

Abstract

Background/Aim: Few data are available on the utility of definitive radiation therapy (RT) for pediatric craniopharyngioma. This study sought to evaluate practice patterns and patient outcomes using the Surveillance Epidemiology and End Results database from 2004-2014. Materials and Methods: Overall survival (OS) was compared between five treatment groups, definitive radiation therapy (RT), gross total resection (GTR), subtotal resection (STR), STR+RT, and observation/biopsy only, using Kaplan–Meier analysis and log-rank tests. Multivariate Cox proportional hazards modeling determined variables independently associated with OS. Results: A total of 373 patients met the study criteria. GTR and definitive RT conferred superior OS than observation/biopsy (p=0.008 and 0.029), but were equivalent to STR+RT (p=0.350 and 0.200). GTR was associated with a higher OS than STR (p=0.027). On multivariate analysis, STR+RT, GTR, and definitive RT were associated with statistically equivalent OS (p=0.990). Conclusion: Definitive RT for pediatric craniopharyngioma affords similar outcomes to established modalities of therapy such as GTR and STR+RT.

Original languageEnglish (US)
Pages (from-to)803-807
Number of pages5
JournalAnticancer Research
Volume39
Issue number2
DOIs
StatePublished - Feb 1 2019

Fingerprint

Craniopharyngioma
Radiotherapy
Pediatrics
Survival
Observation
Biopsy
Epidemiology
Multivariate Analysis
Databases

Keywords

  • Craniopharyngioma
  • Pediatrics
  • Radiotherapy
  • Surgery
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Patterns of care in pediatric craniopharyngioma : Outcomes following definitive radiotherapy. / Hill, Tanner K.; Baine, Michael J.; Verma, Vivek; Alam, Morshed; Lyden, Elizabeth R.; Lin, Chi; Connolly, Eileen P.; Zhang, Chi.

In: Anticancer Research, Vol. 39, No. 2, 01.02.2019, p. 803-807.

Research output: Contribution to journalArticle

Hill, Tanner K. ; Baine, Michael J. ; Verma, Vivek ; Alam, Morshed ; Lyden, Elizabeth R. ; Lin, Chi ; Connolly, Eileen P. ; Zhang, Chi. / Patterns of care in pediatric craniopharyngioma : Outcomes following definitive radiotherapy. In: Anticancer Research. 2019 ; Vol. 39, No. 2. pp. 803-807.
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