Pattern recognition of the multiple sclerosis syndrome

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

During recent decades, the autoimmune disease neuromyelitis optica spectrum disorder (NMOSD), once broadly classified under the umbrella of multiple sclerosis (MS), has been extended to include autoimmune inflammatory conditions of the central nervous system (CNS), which are now diagnosable with serum serological tests. These antibody-mediated inflammatory diseases of the CNS share a clinical presentation to MS. A number of practical learning points emerge in this review, which is geared toward the pattern recognition of optic neuritis, transverse myelitis, brainstem/cerebellar and hemispheric tumefactive demyelinating lesion (TDL)-associated MS, aquaporin-4-antibody and myelin oligodendrocyte glycoprotein (MOG)-antibody NMOSD, overlap syndrome, and some yet-to-be-defined/classified demyelinating disease, all unspecifically labeled under MS syndrome. The goal of this review is to increase clinicians’ awareness of the clinical nuances of the autoimmune conditions for MS and NMSOD, and to highlight highly suggestive patterns of clinical, paraclinical or imaging presentations in order to improve differentiation. With overlay in clinical manifestations between MS and NMOSD, magnetic resonance imaging (MRI) of the brain, orbits and spinal cord, serology, and most importantly, high index of suspicion based on pattern recognition, will help lead to the final diagnosis.

Original languageEnglish (US)
Article number38
JournalBrain Sciences
Volume7
Issue number10
DOIs
StatePublished - Oct 24 2017

Fingerprint

Multiple Sclerosis
Neuromyelitis Optica
Antibodies
Myelin-Oligodendrocyte Glycoprotein
Transverse Myelitis
Aquaporin 4
Optic Neuritis
Central Nervous System Diseases
Demyelinating Diseases
Serologic Tests
Orbit
Serology
Autoimmune Diseases
Brain Stem
Recognition (Psychology)
Spinal Cord
Central Nervous System
Magnetic Resonance Imaging
Learning
Brain

Keywords

  • AQP4 antibodies
  • Brainstem syndrome
  • Clinically isolated syndrome (CIS)
  • MOG antibodies
  • MS
  • NMOSD
  • Optic neuritis
  • Transverse myelitis
  • Tumefactive demyelinating lesions

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Pattern recognition of the multiple sclerosis syndrome. / Zabad, Rana K; Stewart, Renee; Healey, Kathleen.

In: Brain Sciences, Vol. 7, No. 10, 38, 24.10.2017.

Research output: Contribution to journalReview article

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