Patient-Specific Bioinks for 3D Bioprinting of Tissue Engineering Scaffolds

Negar Faramarzi, Iman K. Yazdi, Mahboubeh Nabavinia, Andrea Gemma, Adele Fanelli, Andrea Caizzone, Leon M. Ptaszek, Indranil Sinha, Ali Khademhosseini, Jeremy N. Ruskin, Ali Tamayol

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Bioprinting has emerged as a promising tool in tissue engineering and regenerative medicine. Various 3D printing strategies have been developed to enable bioprinting of various biopolymers and hydrogels. However, the incorporation of biological factors has not been well explored. As the importance of personalized medicine is becoming more clear, the need for the development of bioinks containing autologous/patient-specific biological factors for tissue engineering applications becomes more evident. Platelet-rich plasma (PRP) is used as a patient-specific source of autologous growth factors that can be easily incorporated to hydrogels and printed into 3D constructs. PRP contains a cocktail of growth factors enhancing angiogenesis, stem cell recruitment, and tissue regeneration. Here, the development of an alginate-based bioink that can be printed and crosslinked upon implantation through exposure to native calcium ions is reported. This platform can be used for the controlled release of PRP-associated growth factors which may ultimately enhance vascularization and stem cell migration.

Original languageEnglish (US)
Article number1701347
JournalAdvanced Healthcare Materials
Volume7
Issue number11
DOIs
StatePublished - Jun 6 2018

Fingerprint

Bioprinting
Tissue Scaffolds
Platelet-Rich Plasma
Tissue Engineering
Scaffolds (biology)
Platelets
Tissue engineering
Intercellular Signaling Peptides and Proteins
Hydrogels
Biological Factors
Stem cells
Plasmas
Stem Cells
Tissue regeneration
Precision Medicine
Biopolymers
Regenerative Medicine
Alginate
Ion implantation
Medicine

Keywords

  • 3D bioprinting
  • alginate-based hydrogels
  • patient-specific bioinks
  • platelet-rich plasma (PRP)
  • tissue engineering

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

Cite this

Faramarzi, N., Yazdi, I. K., Nabavinia, M., Gemma, A., Fanelli, A., Caizzone, A., ... Tamayol, A. (2018). Patient-Specific Bioinks for 3D Bioprinting of Tissue Engineering Scaffolds. Advanced Healthcare Materials, 7(11), [1701347]. https://doi.org/10.1002/adhm.201701347

Patient-Specific Bioinks for 3D Bioprinting of Tissue Engineering Scaffolds. / Faramarzi, Negar; Yazdi, Iman K.; Nabavinia, Mahboubeh; Gemma, Andrea; Fanelli, Adele; Caizzone, Andrea; Ptaszek, Leon M.; Sinha, Indranil; Khademhosseini, Ali; Ruskin, Jeremy N.; Tamayol, Ali.

In: Advanced Healthcare Materials, Vol. 7, No. 11, 1701347, 06.06.2018.

Research output: Contribution to journalArticle

Faramarzi, N, Yazdi, IK, Nabavinia, M, Gemma, A, Fanelli, A, Caizzone, A, Ptaszek, LM, Sinha, I, Khademhosseini, A, Ruskin, JN & Tamayol, A 2018, 'Patient-Specific Bioinks for 3D Bioprinting of Tissue Engineering Scaffolds', Advanced Healthcare Materials, vol. 7, no. 11, 1701347. https://doi.org/10.1002/adhm.201701347
Faramarzi N, Yazdi IK, Nabavinia M, Gemma A, Fanelli A, Caizzone A et al. Patient-Specific Bioinks for 3D Bioprinting of Tissue Engineering Scaffolds. Advanced Healthcare Materials. 2018 Jun 6;7(11). 1701347. https://doi.org/10.1002/adhm.201701347
Faramarzi, Negar ; Yazdi, Iman K. ; Nabavinia, Mahboubeh ; Gemma, Andrea ; Fanelli, Adele ; Caizzone, Andrea ; Ptaszek, Leon M. ; Sinha, Indranil ; Khademhosseini, Ali ; Ruskin, Jeremy N. ; Tamayol, Ali. / Patient-Specific Bioinks for 3D Bioprinting of Tissue Engineering Scaffolds. In: Advanced Healthcare Materials. 2018 ; Vol. 7, No. 11.
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