Patient preferences for heart failure treatment: Utilities are valid measures of health-related quality of life in heart failure

Edward P. Havranek, Karen M. Mcgovern, Jennifer Weinberger, Anthony Brocato, Brian D. Lowes, William T. Abraham

Research output: Contribution to journalArticle

45 Scopus citations


Background: Current standards hold that cost-effectiveness analyses should incorporate measures of both quantity and quality of life, and that quality of life in this context is best measured by a utility. We sought to measure utility scores for patients with heart failure and to assess their validity as measures of health-related quality of life (HRQL). Methods and Results: We studied 50 patients with heart failure. We measured utilities with the time trade-off technique, exercise capacity with a 6-minute walk test, and HRQL with the Minnesota Living With Heart Failure questionnaire, the Medical Outcomes Study Short Form-36 (SF-36) questionnaire, and a visual analogue score. Validity was assessed by establishing correlation between utilities and these other measures. Mean utility score was 0.77 ± 0.28. There were significant (P < .05) curvilinear relationships between utility score and visual analogue score, the physical function summary scale of the SF-36, 6-minute walk distance, and the Living With Heart Failure score. Utility scores on retest at I week were unchanged in a subset of 12 patients. Utilities did not vary systematically with age, sex, or ethnicity. Conclusion: Utilities are valid measures of HRQL in patients with heart failure, and cost-effectiveness analyses of heart failure treatments incorporating utilities in the outcome measure can be meaningful.

Original languageEnglish (US)
Pages (from-to)85-91
Number of pages7
JournalJournal of Cardiac Failure
Issue number2
Publication statusPublished - Jun 1999



  • Cost effectiveness analyses
  • Heart failure
  • Quality of life

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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