Pathways towards human immunodeficiency virus elimination

Prasanta K. Dash, Bhavesh D. Kevadiya, Hang Su, Mary G. Banoub, Howard E. Gendelman

Research output: Contribution to journalReview article

Abstract

Antiretroviral therapy (ART) suppresses human immunodeficiency virus (HIV) infection. Research seeking to transform viral suppression into elimination has generated novel immune, chemical and molecular antiviral agents. However, none, to date, have excised latent integrated proviral DNA or removed infected cells from infected persons. These efforts included, but are not limited to, broadly neutralizing antibodies, “shock” and “kill” latency-reversing agents, innate immune regulators, and sequential long-acting antiretroviral nanoformulated prodrugs and CRISPR-Cas9 gene editing. While, the latter, enabled the complete excision of latent HIV-1 from the host genome success was so far limited. We contend that improvements in antiretroviral delivery, potency, agent specificity, or combinatorial therapies can provide a pathway towards complete HIV elimination.

Original languageEnglish (US)
Article number102667
JournalEBioMedicine
Volume53
DOIs
StatePublished - Mar 2020

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Keywords

  • Antiretroviral therapy
  • Broadly neutralizing antibodies
  • CRISPR-Cas9 gene editing
  • HIV-1 tissue reservoirs
  • Latency reversing agents
  • Long-acting slow-effective release antiretroviral therapy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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