Abstract
Understanding of the pathophysiology of osteoporosis has evolved to include compromised bone strength and skeletal fragility caused by several factors: (1) defects in microarchitecture of trabeculae, (2) defective intrinsic material properties of bone tissue, (3) defective repair of microdamage from normal daily activities, and (4) excessive bone remodeling rates. These factors occur in the context of age-related bone loss. Clinical studies of estrogen deprivation, antiresorptives, mechanical loading, and disuse have helped further knowledge of the factors affecting bone quality and the mechanisms that underlie them. This progress has led to several new drug targets in the treatment of osteoporosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 475-486 |
| Number of pages | 12 |
| Journal | Endocrinology and Metabolism Clinics of North America |
| Volume | 41 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 1 2012 |
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Keywords
- Bone quality
- Mechanical loading
- Microdamage
- Osteoporosis
- Remodeling
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Pathophysiology of Osteoporosis. New Mechanistic Insights. / Armas, Laura AG; Recker, Robert R.
In: Endocrinology and Metabolism Clinics of North America, Vol. 41, No. 3, 01.09.2012, p. 475-486.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Pathophysiology of Osteoporosis. New Mechanistic Insights.
AU - Armas, Laura AG
AU - Recker, Robert R.
PY - 2012/9/1
Y1 - 2012/9/1
N2 - Understanding of the pathophysiology of osteoporosis has evolved to include compromised bone strength and skeletal fragility caused by several factors: (1) defects in microarchitecture of trabeculae, (2) defective intrinsic material properties of bone tissue, (3) defective repair of microdamage from normal daily activities, and (4) excessive bone remodeling rates. These factors occur in the context of age-related bone loss. Clinical studies of estrogen deprivation, antiresorptives, mechanical loading, and disuse have helped further knowledge of the factors affecting bone quality and the mechanisms that underlie them. This progress has led to several new drug targets in the treatment of osteoporosis.
AB - Understanding of the pathophysiology of osteoporosis has evolved to include compromised bone strength and skeletal fragility caused by several factors: (1) defects in microarchitecture of trabeculae, (2) defective intrinsic material properties of bone tissue, (3) defective repair of microdamage from normal daily activities, and (4) excessive bone remodeling rates. These factors occur in the context of age-related bone loss. Clinical studies of estrogen deprivation, antiresorptives, mechanical loading, and disuse have helped further knowledge of the factors affecting bone quality and the mechanisms that underlie them. This progress has led to several new drug targets in the treatment of osteoporosis.
KW - Bone quality
KW - Mechanical loading
KW - Microdamage
KW - Osteoporosis
KW - Remodeling
UR - http://www.scopus.com/inward/record.url?scp=84864819754&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864819754&partnerID=8YFLogxK
U2 - 10.1016/j.ecl.2012.04.006
DO - 10.1016/j.ecl.2012.04.006
M3 - Review article
VL - 41
SP - 475
EP - 486
JO - Endocrinology and Metabolism Clinics of North America
JF - Endocrinology and Metabolism Clinics of North America
SN - 0889-8529
IS - 3
ER -