Pathogenicity of an enterotoxigenic Escherichia coli hemolysin (hlyA) mutant in gnotobiotic piglets

Rodney A Moxley, Emil M. Berberov, David H. Francis, Jun Xing, Mahtab Moayeri, Rodney A. Welch, Diane R. Baker, Raul G Barletta

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Pigs infected with hemolytic F4+ strains of enterotoxigenic Escherichia coli often develop septicemia secondary to intestinal infection. We tested the hypothesis that inactivation of hemolysin would reduce the ability of F4+ enterotoxigenic E. coli to cause septicemia in swine following oral inoculation. Inactivation of the hemolysin structural gene (hlyA) did not decrease the incidence of septicemia in the gnotobiotic piglet model.

Original languageEnglish (US)
Pages (from-to)5031-5035
Number of pages5
JournalInfection and immunity
Volume66
Issue number10
StatePublished - Oct 14 1998

Fingerprint

Germ-Free Life
Enterotoxigenic Escherichia coli
Hemolysin Proteins
Virulence
Sepsis
Swine
Incidence
Infection
Genes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Pathogenicity of an enterotoxigenic Escherichia coli hemolysin (hlyA) mutant in gnotobiotic piglets. / Moxley, Rodney A; Berberov, Emil M.; Francis, David H.; Xing, Jun; Moayeri, Mahtab; Welch, Rodney A.; Baker, Diane R.; Barletta, Raul G.

In: Infection and immunity, Vol. 66, No. 10, 14.10.1998, p. 5031-5035.

Research output: Contribution to journalArticle

Moxley, RA, Berberov, EM, Francis, DH, Xing, J, Moayeri, M, Welch, RA, Baker, DR & Barletta, RG 1998, 'Pathogenicity of an enterotoxigenic Escherichia coli hemolysin (hlyA) mutant in gnotobiotic piglets', Infection and immunity, vol. 66, no. 10, pp. 5031-5035.
Moxley RA, Berberov EM, Francis DH, Xing J, Moayeri M, Welch RA et al. Pathogenicity of an enterotoxigenic Escherichia coli hemolysin (hlyA) mutant in gnotobiotic piglets. Infection and immunity. 1998 Oct 14;66(10):5031-5035.
Moxley, Rodney A ; Berberov, Emil M. ; Francis, David H. ; Xing, Jun ; Moayeri, Mahtab ; Welch, Rodney A. ; Baker, Diane R. ; Barletta, Raul G. / Pathogenicity of an enterotoxigenic Escherichia coli hemolysin (hlyA) mutant in gnotobiotic piglets. In: Infection and immunity. 1998 ; Vol. 66, No. 10. pp. 5031-5035.
@article{0aeaf51669c34a53a20b537a083cea50,
title = "Pathogenicity of an enterotoxigenic Escherichia coli hemolysin (hlyA) mutant in gnotobiotic piglets",
abstract = "Pigs infected with hemolytic F4+ strains of enterotoxigenic Escherichia coli often develop septicemia secondary to intestinal infection. We tested the hypothesis that inactivation of hemolysin would reduce the ability of F4+ enterotoxigenic E. coli to cause septicemia in swine following oral inoculation. Inactivation of the hemolysin structural gene (hlyA) did not decrease the incidence of septicemia in the gnotobiotic piglet model.",
author = "Moxley, {Rodney A} and Berberov, {Emil M.} and Francis, {David H.} and Jun Xing and Mahtab Moayeri and Welch, {Rodney A.} and Baker, {Diane R.} and Barletta, {Raul G}",
year = "1998",
month = "10",
day = "14",
language = "English (US)",
volume = "66",
pages = "5031--5035",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "10",

}

TY - JOUR

T1 - Pathogenicity of an enterotoxigenic Escherichia coli hemolysin (hlyA) mutant in gnotobiotic piglets

AU - Moxley, Rodney A

AU - Berberov, Emil M.

AU - Francis, David H.

AU - Xing, Jun

AU - Moayeri, Mahtab

AU - Welch, Rodney A.

AU - Baker, Diane R.

AU - Barletta, Raul G

PY - 1998/10/14

Y1 - 1998/10/14

N2 - Pigs infected with hemolytic F4+ strains of enterotoxigenic Escherichia coli often develop septicemia secondary to intestinal infection. We tested the hypothesis that inactivation of hemolysin would reduce the ability of F4+ enterotoxigenic E. coli to cause septicemia in swine following oral inoculation. Inactivation of the hemolysin structural gene (hlyA) did not decrease the incidence of septicemia in the gnotobiotic piglet model.

AB - Pigs infected with hemolytic F4+ strains of enterotoxigenic Escherichia coli often develop septicemia secondary to intestinal infection. We tested the hypothesis that inactivation of hemolysin would reduce the ability of F4+ enterotoxigenic E. coli to cause septicemia in swine following oral inoculation. Inactivation of the hemolysin structural gene (hlyA) did not decrease the incidence of septicemia in the gnotobiotic piglet model.

UR - http://www.scopus.com/inward/record.url?scp=0031707482&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031707482&partnerID=8YFLogxK

M3 - Article

C2 - 9746614

AN - SCOPUS:0031707482

VL - 66

SP - 5031

EP - 5035

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 10

ER -