Pathogenesis of the granulomatous lung diseases

G. W. Hunninghake, K. C. Garrett, H. B. Richerson, J. C. Fantone, P. A. Ward, S. I. Rennard, P. B. Bitterman, R. G. Crystal

Research output: Contribution to journalReview article

94 Scopus citations


The process of granuloma formation in the lung is triggered, in most instances, by exposure to an antigenic stimulus. Although the numbers of many types of cells are increased in the lung, the antigen exposure leads, primarily, to an increase in the numbers of macrophages and T-lymphocytes. This increase in the numbers of macrophages and T-cells as well as their activation provides the appropriate environment for granuloma formation.

Original languageEnglish (US)
Pages (from-to)476-496
Number of pages21
JournalAmerican Review of Respiratory Disease
Issue number3
StatePublished - Nov 1 1984


ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Hunninghake, G. W., Garrett, K. C., Richerson, H. B., Fantone, J. C., Ward, P. A., Rennard, S. I., Bitterman, P. B., & Crystal, R. G. (1984). Pathogenesis of the granulomatous lung diseases. American Review of Respiratory Disease, 130(3), 476-496.