Pathogenesis and pathophysiology of accelerated atherosclerosis in the diabetic heart

Alicia D'Souza, Munir Hussain, Frank C. Howarth, Niall M. Woods, Keshore R Bidasee, Jaipaul Singh

Research output: Contribution to journalReview article

39 Citations (Scopus)

Abstract

It has been established that atherosclerotic coronary artery disease is more frequent and more severe in diabetic compared to non-diabetic subjects, but the reason for the excess risk of developing coronary macroangiopathy in diabetes remains incompletely characterized. Various biochemical mechanisms speculated to being at the ''heart'' of diabetic cardiac and coronary macroangiopathy are reviewed in the present article. In doing so, this article presents evidence that the labyrinthine interactions of hyperglycemia, insulin resistance, and dyslipidemia in diabetes result in a pro-atherogenic phenotype. Furthermore, the diabetic milieu yields a complex (dys)metabolic environment characterized by chronic inflammation, pro-coagulability, impaired fibrinolysis, neovascularization abnormalities, and microvascular defects that cumulatively alter blood rheology, artery structure, and homeostasis of the endothelium. The contributory influences of these factors in the pathophysiology of coronary artery disease in diabetes are also discussed.

Original languageEnglish (US)
Pages (from-to)89-116
Number of pages28
JournalMolecular and Cellular Biochemistry
Volume331
Issue number1-2
DOIs
StatePublished - Jan 1 2009

Fingerprint

Medical problems
Coronary Artery Disease
Atherosclerosis
Rheology
Fibrinolysis
Dyslipidemias
Hyperglycemia
Endothelium
Insulin Resistance
Homeostasis
Arteries
Inflammation
Phenotype
Blood
Insulin
Defects

Keywords

  • Coronary artery disease hyperglycemia
  • Diabetes mellitus
  • Endothelial dysfunction

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Pathogenesis and pathophysiology of accelerated atherosclerosis in the diabetic heart. / D'Souza, Alicia; Hussain, Munir; Howarth, Frank C.; Woods, Niall M.; Bidasee, Keshore R; Singh, Jaipaul.

In: Molecular and Cellular Biochemistry, Vol. 331, No. 1-2, 01.01.2009, p. 89-116.

Research output: Contribution to journalReview article

D'Souza, Alicia ; Hussain, Munir ; Howarth, Frank C. ; Woods, Niall M. ; Bidasee, Keshore R ; Singh, Jaipaul. / Pathogenesis and pathophysiology of accelerated atherosclerosis in the diabetic heart. In: Molecular and Cellular Biochemistry. 2009 ; Vol. 331, No. 1-2. pp. 89-116.
@article{3ab9b75e9aa647a6b27b143ff269809e,
title = "Pathogenesis and pathophysiology of accelerated atherosclerosis in the diabetic heart",
abstract = "It has been established that atherosclerotic coronary artery disease is more frequent and more severe in diabetic compared to non-diabetic subjects, but the reason for the excess risk of developing coronary macroangiopathy in diabetes remains incompletely characterized. Various biochemical mechanisms speculated to being at the ''heart'' of diabetic cardiac and coronary macroangiopathy are reviewed in the present article. In doing so, this article presents evidence that the labyrinthine interactions of hyperglycemia, insulin resistance, and dyslipidemia in diabetes result in a pro-atherogenic phenotype. Furthermore, the diabetic milieu yields a complex (dys)metabolic environment characterized by chronic inflammation, pro-coagulability, impaired fibrinolysis, neovascularization abnormalities, and microvascular defects that cumulatively alter blood rheology, artery structure, and homeostasis of the endothelium. The contributory influences of these factors in the pathophysiology of coronary artery disease in diabetes are also discussed.",
keywords = "Coronary artery disease hyperglycemia, Diabetes mellitus, Endothelial dysfunction",
author = "Alicia D'Souza and Munir Hussain and Howarth, {Frank C.} and Woods, {Niall M.} and Bidasee, {Keshore R} and Jaipaul Singh",
year = "2009",
month = "1",
day = "1",
doi = "10.1007/s11010-009-0148-8",
language = "English (US)",
volume = "331",
pages = "89--116",
journal = "Molecular and Cellular Biochemistry",
issn = "0300-8177",
publisher = "Springer Netherlands",
number = "1-2",

}

TY - JOUR

T1 - Pathogenesis and pathophysiology of accelerated atherosclerosis in the diabetic heart

AU - D'Souza, Alicia

AU - Hussain, Munir

AU - Howarth, Frank C.

AU - Woods, Niall M.

AU - Bidasee, Keshore R

AU - Singh, Jaipaul

PY - 2009/1/1

Y1 - 2009/1/1

N2 - It has been established that atherosclerotic coronary artery disease is more frequent and more severe in diabetic compared to non-diabetic subjects, but the reason for the excess risk of developing coronary macroangiopathy in diabetes remains incompletely characterized. Various biochemical mechanisms speculated to being at the ''heart'' of diabetic cardiac and coronary macroangiopathy are reviewed in the present article. In doing so, this article presents evidence that the labyrinthine interactions of hyperglycemia, insulin resistance, and dyslipidemia in diabetes result in a pro-atherogenic phenotype. Furthermore, the diabetic milieu yields a complex (dys)metabolic environment characterized by chronic inflammation, pro-coagulability, impaired fibrinolysis, neovascularization abnormalities, and microvascular defects that cumulatively alter blood rheology, artery structure, and homeostasis of the endothelium. The contributory influences of these factors in the pathophysiology of coronary artery disease in diabetes are also discussed.

AB - It has been established that atherosclerotic coronary artery disease is more frequent and more severe in diabetic compared to non-diabetic subjects, but the reason for the excess risk of developing coronary macroangiopathy in diabetes remains incompletely characterized. Various biochemical mechanisms speculated to being at the ''heart'' of diabetic cardiac and coronary macroangiopathy are reviewed in the present article. In doing so, this article presents evidence that the labyrinthine interactions of hyperglycemia, insulin resistance, and dyslipidemia in diabetes result in a pro-atherogenic phenotype. Furthermore, the diabetic milieu yields a complex (dys)metabolic environment characterized by chronic inflammation, pro-coagulability, impaired fibrinolysis, neovascularization abnormalities, and microvascular defects that cumulatively alter blood rheology, artery structure, and homeostasis of the endothelium. The contributory influences of these factors in the pathophysiology of coronary artery disease in diabetes are also discussed.

KW - Coronary artery disease hyperglycemia

KW - Diabetes mellitus

KW - Endothelial dysfunction

UR - http://www.scopus.com/inward/record.url?scp=74049135423&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=74049135423&partnerID=8YFLogxK

U2 - 10.1007/s11010-009-0148-8

DO - 10.1007/s11010-009-0148-8

M3 - Review article

VL - 331

SP - 89

EP - 116

JO - Molecular and Cellular Biochemistry

JF - Molecular and Cellular Biochemistry

SN - 0300-8177

IS - 1-2

ER -