Passive transfer of colostral immunoglobulins in calves

Dusty M. Weaver, Jeff W. Tyler, David C. VanMetre, Douglas E. Hostetler, George M. Barrington

Research output: Contribution to journalReview article

366 Citations (Scopus)

Abstract

Passive transfer of colostral immunoglobulins has long been accepted as imperative to optimal calf health. Many factors, including timing of colostrum ingestion, the method and volume of colostrum administration, the immunoglobulin concentration of the colostrum ingested, and the age of the dam have been implicated in affecting the optimization of absorption. The practice of colostrum pooling, the breed and presence of the dam, and the presence of respiratory acidosis in the calf also may affect passive transfer. Various tests have been reported to accurately measure passive transfer status in neonatal calves. The radial immunodiffusion and the enzyme-linked immunosorbent assay (ELISA) are the only tests that directly measure serum IgG concentration. All other available tests including serum total solids by refractometry, sodium sulfite turbidity test, zinc sulfate turbidity test, serum gamma-glutamyl transferase activity, and whole blood glutaraldehyde gelation estimate serum IgG concentration based on concentration of total globulins or other proteins whose passive transfer is statistically associated with that of IgG. This paper presents a comprehensive review of the literature of passive transfer in calves including factors that affect passive transfer status, testing modalities, effects of failure of passive transfer on baseline mortality, consequences of failure of passive transfer, and some treatment options. Many previously accepted truisms regarding passive transfer in calves should be rejected based on the results of recent research.

Original languageEnglish (US)
Pages (from-to)569-577
Number of pages9
JournalJournal of veterinary internal medicine / American College of Veterinary Internal Medicine
Volume14
Issue number6
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Fingerprint

Colostrum
immunoglobulins
Immunoglobulins
calves
blood serum
colostrum
Immunoglobulin G
Serum
testing
Respiratory Acidosis
Zinc Sulfate
turbidity
Refractometry
Immunodiffusion
Globulins
Glutaral
Transferases
sodium sulfite
zinc sulfate
gamma-glutamyltransferase

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Passive transfer of colostral immunoglobulins in calves. / Weaver, Dusty M.; Tyler, Jeff W.; VanMetre, David C.; Hostetler, Douglas E.; Barrington, George M.

In: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, Vol. 14, No. 6, 01.01.2000, p. 569-577.

Research output: Contribution to journalReview article

Weaver, Dusty M. ; Tyler, Jeff W. ; VanMetre, David C. ; Hostetler, Douglas E. ; Barrington, George M. / Passive transfer of colostral immunoglobulins in calves. In: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine. 2000 ; Vol. 14, No. 6. pp. 569-577.
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